A5077869936- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Pleural and Pulmonary Diseases
- Pneumonia and Respiratory Infections
- Ultrasound in Clinical Applications
- COVID-19 epidemiological studies
- Bone health and osteoporosis research
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Delphi Technique in Research
- Bone health and treatments
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Smoking Behavior and Cessation
- Venous Thromboembolism Diagnosis and Management
- Streptococcal Infections and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
Middlemore Hospital
2015-2024
Counties Manukau District Health Board
2013-2024
University of Auckland
2012-2024
Lung Foundation Australia
2022
St. Jude Children's Research Hospital
2017-2021
University of Hong Kong
2021
Guangzhou Medical University
2021
World Health Organization Regional Office for the Western Pacific
2020
Auckland City Hospital
2020
Ninewells Hospital
2018
Abstract Stringent nonpharmaceutical interventions (NPIs) such as lockdowns and border closures are not currently recommended for pandemic influenza control. New Zealand used these NPIs to eliminate coronavirus disease 2019 during its first wave. Using multiple surveillance systems, we observed a parallel unprecedented reduction of other respiratory viral infections in 2020. This finding supports the use controlling severe threats.
<h3>Abstract</h3> <b>Objective</b>: To determine the prevalence of continuous use oral steroids in general population, conditions for which they are prescribed, and extent to patients taking treatment prevent osteoporosis. <b>Design</b>: A cross sectional study with a four year retrospective review drug treatment. <b>Setting</b>: Eight large practices central southern Nottinghamshire. <b>Subjects</b>: population 65 786 (52% women) registered practitioner during 1995. <b>Results</b>: 303 (65%...
There is a need for clear definition of exacerbations used in clinical trials patients with bronchiectasis. An expert conference was convened to develop consensus an exacerbation use research.A systematic review definitions from January 2000 until December 2015 and involving adults bronchiectasis conducted. A Delphi process followed by round-table meeting experts organised reach definition. These came Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North...
<h3>BACKGROUND</h3> The adverse effects of oral corticosteroids are widely recognised but there few quantitative data on which to base advice patients. In a two part cross sectional study we compared in patients with lung disease taking and control subjects related the corticosteroid dose patient group. <h3>METHODS</h3> Data use, lifestyle, fractures, other possible were collected by questionnaire between community based cohort continuous or frequent intermittent for asthma, chronic...
Concerns about respiratory conditions have surfaced among persons deployed to Iraq and Afghanistan. Data on 46,077 Millennium Cohort Study participants who completed baseline (July 2001-June 2003) follow-up (June 2004-February 2006) questionnaires were used investigate 1) symptoms (persistent or recurring cough shortness of breath), 2) chronic bronchitis emphysema, 3) asthma. Deployers had a higher rate newly reported than nondeployers (14% vs. 10%), while similar rates emphysema (1% 1%)...
Rationale: Intrapleural tissue plasminogen activator (tPA)/deoxyribonuclease (DNase) therapy for pleural infection given at the time of diagnosis has been shown to significantly improve radiological outcomes. Published cases are limited only a single randomized controlled trial and few case reports.Objectives: Multinational observation series evaluate pragmatic "real-life" application tPA/DNase treatment in large cohort unselected patients.Methods: All patients from eight centers who...
Abstract Background New Zealand's (NZ) complete absence of community transmission influenza and respiratory syncytial virus (RSV) after May 2020, likely due to COVID‐19 elimination measures, provided a rare opportunity assess the impact border restrictions on common viral infections over ensuing 2 years. Methods We collected data from multiple surveillance systems, including hospital‐based severe acute infection surveillance, SHIVERS‐II, ‐III ‐IV cohorts for (ARI) HealthStat sentinel general...
In contrast with respiratory disease caused by influenza, information on the risk of syncytial virus (RSV) among adults chronic medical conditions (CMCs) is limited.We linked population-based surveillance acute illness hospitalizations to national administrative data estimate seasonal RSV hospitalization rates aged 18-80 years following preexisting CMCs: obstructive pulmonary (COPD), asthma, congestive heart failure (CHF), coronary artery (CAD), cerebrovascular accidents (CVA), diabetes...
Severe influenza illness is presumed more common in adults with chronic medical conditions (CMCs), but evidence sparse and often combined into broad CMC categories.Residents (aged 18-80 years) of Central South Auckland hospitalized for World Health Organization-defined severe acute respiratory (SARI) (2012-2015) underwent virus polymerase chain reaction testing. The statuses residents were modeled using hospitalization International Classification Diseases, Tenth Revision codes,...
The use of oral corticosteroids is associated with an increased risk fracture, but there limited information on the relationship between corticosteroid dose, bone mineral density (BMD), and fracture. We examined this in a community population (more than 50 years) taking for chronic lung disease. Details lifestyle were obtained by questionnaire, general practice records, patient interview. BMD was assessed at lumbar spine femur vertebral fracture morphometric X-ray absorptiometry. Of 117...
Bronchiectasis is known to cause significant morbidity in children New Zealand. Little of the disease adults.Our objective was characterise a cohort adults who presented hospital with acute exacerbations disease.We retrospectively collected information on all treated as inpatients from single South Auckland, Zealand during 2002.We 307 152 patients. Twenty-seven per cent were Maaori ethnic origin, and 44% Pacific. Seventy lived areas categorised 20% most deprived Comorbid conditions present...
Bronchiectasis not associated with cystic fibrosis is an increasingly recognized chronic lung disease. In Oceania, indigenous populations experience a disproportionately high burden of We aimed to describe the natural history bronchiectasis and identify risk factors premature mortality within cohort Aboriginal Australians, New Zealand Māori Pacific Islanders, non-indigenous Australians Zealanders.This was retrospective study patients aged >15 years at three hospitals: Alice Springs Hospital...
Understanding the attack rate of influenza infection and proportion who become ill by risk group is key to implementing prevention measures. While population-based studies antihemagglutinin antibody responses have been described previously, examining both antineuraminidase antibodies are lacking. In 2015, we conducted a seroepidemiologic cohort study individuals randomly selected from population in New Zealand. We tested paired sera for hemagglutination inhibition (HAI) or neuraminidase...
The extent to which asthma morbidity in the community occurs patients who are having relatively little treatment or those on step 3 above of British management guidelines is uncertain. We have looked at this a population southern Nottinghamshire.A cross sectional review all over age four with diagnosed was carried out five large general practices (population 38 865) 1995/6 using computerised practice records. patients' usual obtained from prescription data and categorised by appropriate...
Background: Recent experience with pandemic influenza A(H1N1)pdm09 highlighted the importance of global surveillance for severe respiratory disease to support preparedness and seasonal control.Improved in southern hemisphere is needed provide critical data on epidemiology, burden, circulating strains effectiveness prevention control measures.Hospital-based acute infection (SARI) cases was established New Zealand 30 April 2012.The aims were me asure incidence, prevalence, risk factors,...
The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with acute respiratory illness (SARI) to those nonhospitalized influenza-like (ILI). Peripheral blood lymphocytes were collected from 27 patients ILI and SARI, at time enrollment then 2 weeks later. Innate adaptive cellular assessed by flow cytometry, serum cytokine levels a bead-based assay. During phase, SARI was...
Pleural procedures may cause serious complications when incorrectly carried out. There is a need to find effective methods for teaching how insert chest drain safely.To assess the effectiveness of programme tube insertion using simulation model (SuperAnnie).Groups four six junior doctors were enrolled in 2-h session, covering both theoretical knowledge and practical techniques model. Before module, participants completed questionnaire about their confidence skill levels videotaped inserting...
The challenges associated with diagnosing tuberculous pleural effusion have led to the use of fluid adenosine deaminase (pfADA) as a biomarker for Mycobacterium tuberculosis infection. This study retrospectively reviewed diagnostic performance pfADA, lactate dehydrogenase (LD)/ADA ratio, and combinations these two parameters in 1,637 episodes low-tuberculosis (TB)-incidence setting Auckland, Aotearoa New Zealand, from between March 2008 November 2014. median pfADA 57 TB (58.1 U/liter) was...
Background Respiratory syncytial virus (RSV) is increasingly recognized as an important cause of illness in adults; however, data on RSV disease and economic burden this age group remain limited. We aimed to provide comprehensive estimates among adults aged ≥18 years. Methods During 2012–2015, population-based, active surveillance acute respiratory infection (ARI) hospitalizations enabled estimation the seasonal incidence direct health costs years Auckland, New Zealand. Results Of 4,600 ARI...
Background Tiotropium via the HandiHaler device is an established long-acting, anticholinergic bronchodilator that prevents exacerbations and improves lung function in patients with chronic obstructive pulmonary disease. We hypothesised tiotropium would reduce improve stable bronchiectasis airflow limitation, assessed effect of on these outcomes. Methods In a randomised, double-blind, two-period crossover trial, we recruited adult from three hospitals New Zealand. Patients were excluded if...