A5021897642- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Child Development and Digital Technology
- Genetics and Neurodevelopmental Disorders
- Child Nutrition and Feeding Issues
- Attention Deficit Hyperactivity Disorder
- Behavioral and Psychological Studies
- Virology and Viral Diseases
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Child and Adolescent Psychosocial and Emotional Development
- Congenital heart defects research
- Mobile Learning in Education
- Higher Education Learning Practices
- Vaccine Coverage and Hesitancy
- Neurobiology of Language and Bilingualism
- Obsessive-Compulsive Spectrum Disorders
- Early Childhood Education and Development
- Innovations in Educational Methods
- Advanced biosensing and bioanalysis techniques
- Geography Education and Pedagogy
- Williams Syndrome Research
- Paraoxonase enzyme and polymorphisms
- Spatial Cognition and Navigation
- Inhalation and Respiratory Drug Delivery
Southwest Autism Research & Resource Center
2015-2024
University of Tennessee at Knoxville
2020
Barrow Neurological Institute
2019
Grand Valley State University
2012
Gravesham Community Hospital
2011
Montefiore Medical Center
2011
Icahn School of Medicine at Mount Sinai
2011
St. John's University
2011
Albert Einstein College of Medicine
2011
University of Bolton
2010
There is a rapidly growing group of aging adults with autism spectrum disorder (ASD) who may have unique needs, yet cognitive and brain function in older ASD understudied. We combined functional structural neuroimaging neuropsychological tests to examine differences between middle‐aged men matched neurotypical (NT) men. Participants (ASD, n = 16; NT, 17) aged 40–64 years were well‐matched according age, IQ (range: 83–131), education 9–20 years). Middle‐age made more errors on an executive...
Importance In the US, children with signs of autism often experience more than 1 year delay before diagnosis and longer delays if they are from racially, ethnically, or economically disadvantaged backgrounds. Most diagnoses also received without use standardized diagnostic instruments. To aid in early diagnosis, eye-tracking measurement social visual engagement has shown potential as a performance-based biomarker. Objective evaluate performance (index test) relative to expert clinical young...
Research indicates that a substantial amount of time elapses between parents' first concerns about their child's development and formal diagnosis autism spectrum disorder (ASD). Telehealth presents an opportunity to expedite the diagnostic process. This project compared novel telehealth approach utilizes clinically guided in-home video recordings gold standard in-person assessment. Participants included 40 families seeking ASD evaluation for child 11 typically developing children. Children...
Converging lines of evidence point to the existence immune dysfunction in autism spectrum disorder (ASD), which could directly affect several key neurodevelopmental processes. Previous studies have shown higher cytokine levels patients with compared matched controls or subjects other developmental disorders. In current study, we used plasma-cytokine profiling for 25 discordant sibling pairs evaluate whether these alterations occur within families ASD. Plasma-cytokine was conducted using an...
Observing behavior in the natural environment is valuable to obtain an accurate and comprehensive assessment of a child's behavior, but practice it limited in-clinic observation. Research shows significant time lag between when parents first become concerned child finally diagnosed with autism. This can delay early interventions that have been shown improve developmental outcomes.To develop evaluate design asynchronous system allows easily collect clinically valid in-home videos their...
Clinical heterogeneity of autism likely hinders efforts to find genes associated with this complex psychiatric disorder. Some studies have produced promising results by restricting the sample according expression specific familial factors or components autism. Previous factor analyses restricted, repetitive behaviors and interest (RRBI) domain consistently identified a two-factor model that explains moderate amount variance. The identification additional may explain more variance in RRBI...
This study examined the feasibility and acceptability of a telehealth diagnostic model deployed at an autism center in southwestern United States to safely provide spectrum disorder (ASD) evaluations children, adolescents, adults during COVID-19 pandemic. Participants included all clients for whom evaluation was scheduled clinic (n = 121) over 6-month period. Of 121 clients, 102 (84%) completed evaluation. A determination made 91% (93 out 102) using only procedures. Nine participants (two...
The male preponderance in autism spectrum disorder (ASD) led to the hypothesis that aspects of female biology are protective against ASD. Females with ASD (ASD-F) report more compensatory behaviors (i.e. "camouflaging") overcome ASD-related social differences, which may be a mechanism protection. No studies have examined sex-related brain pathways supporting camouflaging ASD-F, despite its potential inform mechanisms underlying sex bias. We used functional connectivity (FC) investigate...
Individuals with severe to profound and multiple intellectual disability (S-PMID) tend function at the earlier stages of communication development. Variable highly individual means communicating may present challenges adults providing support in everyday life. The current study aimed examine interface between students S-PMID educational staff.An in-depth, observational dyadic interaction a class within secondary part special school was conducted. designated level Key Stage 3 under National...
Objective: The Janssen Autism Knowledge Engine (JAKE®) is a clinical research outcomes assessment system developed to more sensitively measure treatment and identify subpopulations in autism spectrum disorder (ASD). Here we describe JAKE present results from its digital phenotyping (My JAKE) biosensor (JAKE Sense) components. Methods: An observational, non-interventional, prospective study of children adults with ASD was conducted at nine sites the United States. Feedback on usability...
The authors carried out a factor analysis of the Yale-Brown Obsessive-Compulsive Scale checklist at category level in order to reduce number variables this domain and ultimately identify possible endophenotypes; 181 children with autism were enrolled. estimated tetrachoric correlation matrix among dichotomous symptom categories then used exploratory confirmatory analyses clinically meaningful structure for matrix. Their supported four-factor solution: obsessions, higher-order repetitive...