A5063842168- Autism Spectrum Disorder Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Child Development and Digital Technology
- Multiple Sclerosis Research Studies
- Heart Rate Variability and Autonomic Control
- Sleep and related disorders
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Non-Invasive Vital Sign Monitoring
- Fungal and yeast genetics research
- Gene Regulatory Network Analysis
- Microgrid Control and Optimization
- Obsessive-Compulsive Spectrum Disorders
- Mobile Health and mHealth Applications
- Smart Grid Energy Management
- Microbial Metabolic Engineering and Bioproduction
- Effects of Vibration on Health
- Mosquito-borne diseases and control
- Autoimmune and Inflammatory Disorders Research
- Distributed Control Multi-Agent Systems
- Indoor Air Quality and Microbial Exposure
- Attention Deficit Hyperactivity Disorder
- Health Systems, Economic Evaluations, Quality of Life
- Single-cell and spatial transcriptomics
- Sleep and Work-Related Fatigue
Janssen (United States)
2018-2025
Janssen (Belgium)
2024
Springhouse
2018-2020
Yale University
2018
Abstract Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. Wearable sensors, like inertial measurement units (IMUs), offer a way to monitor daily activities evaluate functional capacity. This study investigates the relationship between sit-to-stand stand-to-sit transitions self-reported physical mental fatigue participants with...
The relationship between sleep (caregiver-reported and actigraphy-measured) other caregiver-reported behaviors in children adults with autism spectrum disorder (ASD) was examined, including the use of machine learning to identify variables important predicting anxiety ASD.Caregivers ASD (n = 144) typically developing (TD) 41) participants reported on behaviors. wore an actigraphy device at nighttime during 8 or 10-week non-interventional study. Mean variability measures for week preceding...
Abstract Background Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent this discrepancy is limited and inconsistent. Use automated detection technology enables accurate efficient tracking expressions that has potential to identify individual response differences. Methods Children adults with ASD ( N = 124) typically developing (TD, 41) were shown short clips “funny videos.” Using analysis software,...
Currently, no medications are approved to treat core symptoms of autism spectrum disorder (ASD). One barrier ASD medication development is the lack validated outcome measures able detect symptom change. Current interventions often evaluated using retrospective caregiver reports that describe general clinical presentation but require recall specific behaviors weeks after they occur, potentially reducing accuracy ratings. My JAKE, a mobile and Web-based health (mHealth) app part Janssen Autism...
Objective: The Janssen Autism Knowledge Engine (JAKE®) is a clinical research outcomes assessment system developed to more sensitively measure treatment and identify subpopulations in autism spectrum disorder (ASD). Here we describe JAKE present results from its digital phenotyping (My JAKE) biosensor (JAKE Sense) components. Methods: An observational, non-interventional, prospective study of children adults with ASD was conducted at nine sites the United States. Feedback on usability...
Innovative Medicines Initiative (IMI) consortium IDEA-FAST is developing novel digital measures of fatigue, sleep quality, and impact disturbances for neurodegenerative diseases immune-mediated inflammatory diseases. In 2022, the met with European Agency (EMA) to receive advice on its plans regulatory qualification measures. This viewpoint reviews perspective multiple provided by EMA.The EMA considered a cross-disease measure an interesting arguably feasible concept. Developers should...
Abstract Remote inflammation monitoring with digital health technologies (DHTs) would provide valuable information for both clinical research and care. Controlled perturbations of the immune system may reveal physiological signatures which could be used to develop a biomarker inflammatory state. In this study, molecular profiling was performed following an in vivo lipopolysaccharide (LPS) challenge inflammation. Ten healthy volunteers received intravenous LPS were monitored 24 h using...
Wearables with photoplethysmography (PPG) sensors are being increasingly used in clinical research as a non-invasive, inexpensive method for remote monitoring of physiological health. Ensuring the accuracy and reliability PPG-derived measurements is critical, inaccuracies can impact findings decisions. This paper systematically compares heart rate (HR) variability (HRV) measures from PPG against an electrocardiogram (ECG) monitor free-living settings. Two devices one device ECG sensor were...
Eye‐tracking studies have demonstrated that individuals with autism spectrum disorder sometimes show differences in attention and gaze patterns. This includes preference for certain nonsocial objects, heightened to detail, more difficulty shifting disengagement, which may be associated restricted repetitive behaviors. study utilized a visual exploration task replicates findings of reduced number objects explored increased fixation duration on high interest large sample ( n = 129, age 6–54...
For the patient community with neurodegenerative disorders (NDD) and immune-mediated inflammatory diseases (IMID), fatigue sleep disturbances stand out as two of most common disabling symptoms, which mightily impair patient's quality life. Traditional questionnaire-oriented approaches to reflect such symptoms suffer from recall bias poor sensitivity change. By virtue multiple sensing modalities at home, IDEA-FAST project aims identify novel digital endpoints disturbances, that are objective,...
Problems with fatigue and sleep are highly prevalent in patients chronic diseases often rated among the most disabling symptoms, impairing their activities of daily living health-related quality life (HRQoL). Currently, they evaluated primarily via Patient Reported Outcomes (PROs), which can suffer from recall biases have limited sensitivity to temporal variations. Objective measurements wearable sensors allow reliably quantify disease state, changes HRQoL, evaluate therapeutic outcomes....
Cells often respond to environmental stimuli by activating specific transcription factors. Upon exposure glucose limitation stress, it is known that yeast Saccharomyces cerevisiae cells dephosphorylate the general stress response factor Msn2, leading its nuclear localization, which in turn activates expression of many genes. However, precise dynamics Msn2 nucleocytoplasmic translocations and whether they are inherited over multiple generations a stress-dependent manner not well understood....
Abstract Background Emerging digital measures and clinical outcome assessments (COAs) leveraging health technologies (DHTs) could address the need for objective, quantitative of symptoms atopic dermatitis (AD), such as nocturnal scratching. Development needs to be supported by evidence reflecting meaningfulness patients. Objectives To assess scratching a concept interest associated with meaningful aspects patients AD (adults children); explore patient‐centred considerations novel COAs...
Abstract Background Many individuals with neurodegenerative (NDD) and immune-mediated inflammatory disorders (IMID) experience debilitating fatigue. Currently, assessments of fatigue rely on patient reported outcomes (PROs), which are subjective prone to recall biases. Wearable devices, however, provide objective reliable estimates gait, an essential component health, may present evidence This study explored the relationships between gait characteristics derived from inertial measurement...
Current assessments of fatigue and sleepiness rely on patient reported outcomes (PROs), which are subjective prone to recall bias. The current study investigated the use gait variability in "real world" identify daytime sleepiness. Inertial measurement units were worn lower backs 159 participants (117 with six different immune neurodegenerative disorders 42 healthy controls) for up 20 days, whom completed regular PROs. To address walking bouts that short sparse, four feature groups...
<title>Abstract</title> Fatigue is a complex, multi-faceted phenomenon that particularly common in immune-mediated inflammatory disease and neurodegenerative cohorts. Clinical assessment of fatigue relies heavily on patient-reported outcomes (PROs), provide only the perception aspect poorly capture fluctuations over time. The use wearable sensors, e.g., inertial measurement units, overcome these drawbacks, by allowing for capacity performance aspects health through continuous monitoring...
Eye tracking studies have demonstrated deficits in attention individuals with Autism Spectrum Disorder (ASD) for a range of different social attention-based tasks. Here we examined skills large sample ASD participants (n = 120), using eye data from information processing task, and compared them typically developing (TD) group 35). Assuming movement parameters are random variables generated by an underlying stochastic process, modeled the fixation sequences TD groups Hidden Markov Model. The...
This study focusses on self-balancing microgrids to smartly utilize and prevent overdrawing of available power capacity the grid. A distributed framework for automated distribution optimal demand is proposed, where all building in a microgrid dynamically simultaneously adjusts their own consumption reach individual demands while cooperatively striving maintain overall grid stable. Emphasis has been given aspects algorithm that yields lower time convergence demonstrated through quantitative...
This report formulates a minimal model based on control theoretic framework to best describe the dynamics of perfect adaptation shown by hyper osmotic shock response system in yeast. Using principles from adaptive and stability theory, we step apply identification methods build simple second order linear with only few parameters, that can concisely High Osmolarity Glycerol (HOG) Mitogen Activated Protein Kinase (MAPK) signaling dynamics. Validation experimental data demonstrate is sufficient...
<sec> <title>BACKGROUND</title> Currently, no medications are approved to treat core symptoms of autism spectrum disorder (ASD). One barrier ASD medication development is the lack validated outcome measures able detect symptom change. Current interventions often evaluated using retrospective caregiver reports that describe general clinical presentation but require recall specific behaviors weeks after they occur, potentially reducing accuracy ratings. My JAKE, a mobile and Web-based health...