Kieren Allinson
A5068160411- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Cancer Genomics and Diagnostics
- Neurological disorders and treatments
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Dementia and Cognitive Impairment Research
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
- Neurological diseases and metabolism
- Chromatin Remodeling and Cancer
- Brain Metastases and Treatment
- S100 Proteins and Annexins
- Long-Term Effects of COVID-19
- Prion Diseases and Protein Misfolding
- Cellular transport and secretion
- Genomics and Rare Diseases
- Cancer, Hypoxia, and Metabolism
Cambridge University Hospitals NHS Foundation Trust
2017-2025
University of Cambridge
2015-2025
MRC Cognition and Brain Sciences Unit
2018-2024
Addenbrooke's Hospital
2014-2023
National Health Service
2019-2022
Medical Research Council
2018-2019
Cancer Research UK
2019
University College London Hospitals NHS Foundation Trust
2018
University College London
2018
Institute of Molecular Bioimaging and Physiology
2018
Alzheimer's disease and progressive supranuclear palsy (PSP) represent neurodegenerative tauopathies with predominantly cortical versus subcortical burden. In disease, neuropathology atrophy preferentially affect 'hub' brain regions that are densely connected. It was unclear whether hubs differentially affected by neurodegeneration because they more likely to receive pathological proteins propagate trans-neuronally, in a prion-like manner, or selectively vulnerable due lack of local trophic...
The ability to assess the distribution and extent of tau pathology in Alzheimer's disease progressive supranuclear palsy vivo would help develop biomarkers for these tauopathies clinical trials disease-modifying therapies. New radioligands positron emission tomography have generated considerable interest, controversy, their potential as biomarkers. We assessed radiotracer 18F-AV-1451 with imaging compare intensity 15 patients (including amyloid-positive mild cognitive impairment), 19 palsy,...
Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be difficult to distinguish in early stages are often misdiagnosed as Parkinson disease (PD). The diagnostic criteria for PSP have been updated encompass a range of clinical subtypes but not prospectively studied.To define the distinguishing features CBS assess their usefulness facilitating diagnosis separation from PD.This cohort study...
The accumulation of amyloid Tau aggregates is implicated in Alzheimer's disease (AD) and other tauopathies. Molecular chaperones are known to maintain protein homeostasis. Here, we show that an ATP-dependent human chaperone system disassembles fibrils vitro We found this function mediated by the core HSC70, assisted specific cochaperones, particular class B J-domain proteins a heat shock 110 (Hsp110)-type nucleotide exchange factor (NEF). Hsp70 disaggregation machinery processed recombinant...
Abstract Parkinson’s disease dementia is neuropathologically characterized by aggregates of α-synuclein (Lewy bodies) in limbic and neocortical areas the brain with additional involvement Alzheimer’s disease-type pathology. Whilst immune activation well-described (PD), how it links to protein aggregation its role PD has not been explored. We hypothesized that neuroinflammatory processes are a critical contributor pathology PDD. To address this hypothesis, we examined 7 regions at postmortem...
We tested whether in vivo neuroinflammation relates to the distinctive distributions of pathology Alzheimer disease (AD) and progressive supranuclear palsy (PSP).Sixteen patients with symptomatic AD (including amnestic mild cognitive impairment amyloid-positive PET scan), 16 PSP-Richardson syndrome, 13 age-, sex-, education-matched healthy controls were included this case-control study. Participants underwent [11C]PK11195 scanning, which was used as an index neuroinflammation.[11C]PK11195...
Local replication doubles the number of tau aggregate in Alzheimer’s disease only once every 5 years, limiting overall rate.
The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum. We investigated how relates to localization tau TDP-43 pathology, heterogeneity disease. used PET in vivo with (i) 11C-PK-11195, a marker activated microglia proxy index neuroinflammation; (ii) 18F-AV-1451, radioligand increased binding pathologically affected regions tauopathies TDP-43-related disease,...
To describe the neuropathological findings in two cases of fatal Coronavirus Disease 2019 (COVID-19) with neurological decline.Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection was confirmed both patients by reverse transcription polymerase chain reaction (RT-PCR) from nasopharyngeal swabs antemortem. Coronial autopsies were performed on and histological sampling brain undertaken a variety histochemical immunohistochemical stains. RNAscope® situ hybridization (ISH) using...
Abstract Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning MRT are not firmly established. Here, we study the origin of by combining phylogenetic analyses single-cell mRNA studies in patient-derived organoids. Comparison somatic mutations shared between surrounding normal tissues places a lineage with neural crest-derived Schwann...
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms common, seemingly unrelated to severity. The true frequency underlying mechanisms of injury are unknown, but exaggerated host inflammatory responses appear be key driver We investigated the dynamics of, relationship between, serum markers brain [neurofilament light (NfL), glial fibrillary acidic protein (GFAP) total tau]...
Clinical whole-genome sequencing (WGS) has been shown to deliver potential benefits children with cancer and alter treatment in high-risk patient groups. It remains unknown whether offering WGS every child suspected can change management. We collected variant calls clinical diagnostic information from 281 (282 tumors) across two English units (n = 152 a hematology center, n 130 solid tumor center) where had become routine test. Our key finding was that variants uniquely attributable changed...
Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology. It provides a useful model in which to test specificity vivo putative tau ligand [18F]AV-1451, elevated frontotemporal lobar degeneration tauopathies.Seven patients (five svPPA and two 'right' dementia) 12 healthy controls underwent positron emission tomography brain imaging [18F]AV-1451. Two independent preprocessing...
Abstract Background Whole-genome sequencing (WGS) of cancers is becoming an accepted component oncological care, and NHS England currently rolling out WGS for all children with cancer. This approach was piloted during the 100,000 genomes (100 K) project. Here we share experience East Genomic Medicine Centre (East-GMC), reporting feasibility clinical utility centralised individual locally. Methods Non-consecutive solid tumours were recruited into pilot 100 K project at our Centre. Variant...
Abstract Background Seed amplification assay (SAA) testing has been developed as a biomarker for the diagnosis of α‐synuclein‐related neurodegenerative disorders. Objective The objective this study was to assess rate α‐synuclein SAA positivity in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) analyze clinical pathological features SAA‐positive ‐negative cases. Methods A total 96 cerebrospinal fluid samples from clinically diagnosed PSP (n = 59) CBS 37) cases were...
Purpose To explore the diffusion-tensor (DT) imaging–defined invasive phenotypes of both isocitrate dehydrogenase (IDH-1)–mutated and IDH-1 wild-type glioblastomas. Materials Methods Seventy patients with glioblastoma were prospectively recruited imaged preoperatively. All provided signed consent, local research ethics committee approved study. Patients underwent surgical resection, tumor samples immunohistochemistry for R132H mutations. DT imaging data coregistered to anatomic magnetic...
Abstract Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome methylation profiles primary recurrent anaplastic meningioma. A key finding was delineation distinct molecular subgroups that were associated with diametrically opposed survival Relative to lower grade meningiomas, tumors harbored frequent driver mutations in SWI/SNF complex genes, which...
Clinical behaviour of atypical meningiomas is not uniform. While, as a group, they exhibit high recurrence rate, some pursue more benign course, whereas others progress early. We aim to investigate the imaging and pathological factors that predict risk early tumour progression determine whether related outcome. Adult patients with WHO grade II meningioma treated in three regional referral centres between 2007 2014 were included. MRI pathology characteristics assessed. Gross total resection...
Background: Genetic factors that influence Alzheimer's disease (AD) risk include mutations in TREM2 and allelic variants of Apolipoprotein E, influencing AD pathology the general population Down syndrome (DS).Evidence shows dysfunction choroid plexus may compromise blood-cerebrospinal fluid (CSF) barrier, altering secretory, transport immune function can affect pathology.Objective: To investigate genotype phenotype DS individuals relation to damage blood-CSF barrier leakage identify markers...