Jonathan Coles
A5028469602- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Neurosurgical Procedures and Complications
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Sepsis Diagnosis and Treatment
- Down syndrome and intellectual disability research
- Radiation Dose and Imaging
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Anesthesia and Neurotoxicity Research
- Spinal Fractures and Fixation Techniques
- Anesthesia and Sedative Agents
University of Cambridge
2016-2025
Cambridge University Hospitals NHS Foundation Trust
2008-2025
Addenbrooke's Hospital
2015-2024
Universitätsmedizin Göttingen
2021-2022
University of Groningen
2022
Karolinska Institutet
2022
University of Göttingen
2022
Heidelberg University
2021
MRC Cognition and Brain Sciences Unit
2021
Oxford University Hospitals NHS Trust
2021
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative 19 transporters across nine different neurotransmitter systems. We found that profiles...
Microdialysis enables the chemistry of extracellular interstitial space to be monitored. Use this technique in patients with acute brain injury has increased our understanding pathophysiology several neurological disorders. In 2004, a consensus document on clinical application cerebral microdialysis was published. Since then, there have been significant advances use neurocritical care. The objective review is report International Forum held Cambridge, UK, April 2014 and produce revised...
Abstract Introduction The dural sheath surrounding the optic nerve communicates with subarachnoid space, and distends when intracranial pressure is elevated. Magnetic resonance imaging (MRI) often performed in patients at risk for raised (ICP) can be used to measure precisely diameter of its sheath. objective this study was assess relationship between (ONSD), as measured using MRI, ICP. Methods We conducted a retrospective blinded analysis brain MRI images prospective cohort 38 requiring ICP...
ObjectiveWe aimed to explore the added value of common machine learning (ML) algorithms for prediction outcome moderate and severe traumatic brain injury.Study Design SettingWe performed logistic regression (LR), lasso regression, ridge with key baseline predictors in IMPACT-II database (15 studies, n = 11,022). ML included support vector machines, random forests, gradient boosting artificial neural networks were trained using same predictors. To assess generalizability predictions, we...
Background: Increasingly neurological complications of COVID-19 are identified, mostly in small series. Larger studies have been limited by both geography and specialty.Consequently, the breadth is not represented. Comprehensive characterization clinical syndromes critical to rationally select evaluate potential therapies.Methods: During exponential pandemic phase, we developed coordinated online portals for rapid notification across spectrum major UK neuroscience bodies, representing...
To use a range of techniques to explore diffusion limitation as mechanism cellular hypoxia in the setting head injury.A prospective interventional study.A specialist neurocritical care unit.Thirteen patients within 7 days closed injury underwent imaging studies. Tissue for ultrastructural studies was obtained from cohort seven who required surgery.Cerebral tissue PO2 (PtO2) using multiple-variable sensor, and images oxygen extraction fraction (OEF), derived positron emission tomography, were...
Objective To investigate the effect of hyperventilation on cerebral blood flow in traumatic brain injury. Design A prospective interventional study. Setting specialist neurocritical care unit. Patients Fourteen healthy volunteers and 33 patients within 7 days closed head Interventions All subjects underwent positron emission tomography imaging flow. In patients, Paco2 was reduced from 36 ± 1 to 29 torr (4.8 0.1 3.9 kPa) measurements repeated. Jugular venous saturation (Sjvo2) arteriovenous...
Antemortem demonstration of ischemia has proved elusive in head injury because regional CBF reductions may represent hypoperfusion appropriately coupled to hypometabolism. Fifteen patients underwent positron emission tomography within 24 hours map cerebral blood flow (CBF), oxygen metabolism (CMRO2), and extraction fraction (OEF). We estimated the volume ischemic brain (IBV) used standard deviation OEF distribution estimate efficiency coupling between CMRO2. The IBV was significantly higher...
Objective: To determine whether hyperventilation exacerbates cerebral ischemia and compromises oxygen metabolism (CMRO2) following closed head injury. Design: A prospective interventional study. Setting: specialist neurocritical care unit. Patients: Ten healthy volunteers 30 patients within 10 days of Interventions: Subjects underwent oxygen-15 positron emission tomography imaging blood flow, volume, CMRO2, extraction fraction. In patients, studies, somatosensory evoked potentials, jugular...
Objective: In this study we have used 15O positron emission tomography, brain tissue oxygen monitoring, and cerebral microdialysis to assess the effects of perfusion pressure augmentation on regional physiology metabolism in setting traumatic injury. Design: Prospective interventional study. Setting: Neurosciences critical care unit a university hospital. Patients: Eleven acutely head-injured patients requiring norepinephrine maintain pressure. Interventions: Using quantified response an...
Adults with Down syndrome (DS) invariably develop Alzheimer's disease (AD) neuropathology. Understanding amyloid deposition in DS can yield crucial information about pathogenesis.Forty-nine adults aged 25-65 underwent positron emission tomography Pittsburgh compound-B (PIB). Regional PIB binding was assessed respect to age, clinical, and cognitive status.Abnormal became evident from 39 years, first striatum followed by rostral prefrontal-cingulo-parietal regions, then caudal frontal,...
To determine the effect of normobaric hyperoxia on cerebral metabolism in patients with severe traumatic brain injury.Prospective clinical investigation.Neurosciences critical care unit a university hospital.Eleven injury.Cerebral microdialysis, tissue oximetry (PbO2), and oxygen-15 positron emission tomography (15O-PET) were undertaken at normoxia repeated (FiO2 increase between 0.35 0.50).Established models used to image blood flow, volume, oxygen metabolism, extraction fraction....
To image amyloid deposition in patients with traumatic brain injury (TBI) using carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) and to validate these findings tritium-labeled PiB ([3H]PiB) autoradiography immunocytochemistry autopsy-acquired tissue.In vivo PET at tertiary neuroscience referral center ex of tissue from a neuropathology archive. [11C]PiB was used 11 controls (median [range] age, 35 [24-60] years) 15 33 [21-50] between 1 361 days after TBI....
Combined oxygen 15-labeled positron emission tomography (15O PET) and brain tissue oximetry have demonstrated increased diffusion gradients in hypoxic regions after traumatic injury (TBI). These data are consistent with microvascular ischemia supported by pathologic studies showing widespread collapse, perivascular edema, microthrombosis associated selective neuronal loss. Fluorine 18-labeled fluoromisonidazole ([18F]FMISO), a PET tracer that undergoes irreversible bioreduction within cells,...
Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children young adults. TBI an example medical condition where there are still lacks diagnostics outcome prediction. Here we apply comprehensive metabolic profiling serum samples from patients controls two independent cohorts. The discovery study included 144 patients, with the taken at time hospitalization. were diagnosed as severe (sTBI; n=22), moderate (moTBI; n=14) or mild (mTBI; n=108)...
Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...
Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are promising biomarkers of traumatic brain injury (TBI).We investigated the relation GFAP UCH-L1 levels to severity TBI during first week after injury.Plasma were measured from 324 consecutive patients with acute 81 control subject enrolled in a 2-center prospective study. The baseline measures included initial Glasgow Coma Scale (GCS), head computed tomographic (CT) scan at admission, blood samples for...
The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum. We investigated how relates to localization tau TDP-43 pathology, heterogeneity disease. used PET in vivo with (i) 11C-PK-11195, a marker activated microglia proxy index neuroinflammation; (ii) 18F-AV-1451, radioligand increased binding pathologically affected regions tauopathies TDP-43-related disease,...
<h3>Importance</h3> A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown be associated outcomes. mild (mTBI; GCS 13-15), distribution and co-occurrence of pathological their prognostic importance are not well understood. <h3>Objective</h3> To identify adverse outcomes after mTBI....
Abstract Background Synaptic loss is a prominent and early feature of many neurodegenerative diseases. Objectives We tested the hypothesis that synaptic density reduced in primary tauopathies progressive supranuclear palsy (PSP) (Richardson’s syndrome) amyloid‐negative corticobasal syndrome (CBS). Methods Forty‐four participants (15 CBS, 14 PSP, 15 age‐/sex‐/education‐matched controls) underwent PET with radioligand [ 11 C]UCB‐J, which binds to vesicle glycoprotein 2A, marker density; also...