Peter Bragge
A5048177223- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Health Policy Implementation Science
- Cardiac Arrest and Resuscitation
- Clinical practice guidelines implementation
- Meta-analysis and systematic reviews
- Primary Care and Health Outcomes
- Health Sciences Research and Education
- Health Systems, Economic Evaluations, Quality of Life
- Emergency and Acute Care Studies
- Mental Health and Patient Involvement
- Spinal Cord Injury Research
- Patient-Provider Communication in Healthcare
- Interprofessional Education and Collaboration
- Clinical Reasoning and Diagnostic Skills
- Musicians’ Health and Performance
- Patient Satisfaction in Healthcare
- Evaluation and Performance Assessment
- Delphi Technique in Research
- Sports injuries and prevention
- Patient Safety and Medication Errors
- Musculoskeletal Disorders and Rehabilitation
- Musculoskeletal pain and rehabilitation
- Urinary Bladder and Prostate Research
Monash University
2016-2025
Sustainable Development Institute
2022-2023
Sax Institute
2023
University of Cambridge
2022-2023
Marshall Medical Center
2014-2023
Kennedy Center
2023
Addenbrooke's Hospital
2022-2023
Australian Regenerative Medicine Institute
2018-2023
Stiftung Liebenau (Germany)
2022
Integra LifeSciences (United States)
2022
Evidence mapping describes the quantity, design and characteristics of research in broad topic areas, contrast to systematic reviews, which usually address narrowly-focused questions. The breadth evidence helps identify gaps, may guide future efforts. Global Mapping (GEM) Initiative was established 2007 create maps providing an overview existing Traumatic Brain Injury (TBI) Spinal Cord (SCI). GEM method involved three core tasks: 1. Setting boundaries context map: Definitions for fields TBI...
ObjectiveWe aimed to explore the added value of common machine learning (ML) algorithms for prediction outcome moderate and severe traumatic brain injury.Study Design SettingWe performed logistic regression (LR), lasso regression, ridge with key baseline predictors in IMPACT-II database (15 studies, n = 11,022). ML included support vector machines, random forests, gradient boosting artificial neural networks were trained using same predictors. To assess generalizability predictions, we...
Introduction: Moderate to severe traumatic brain injury (TBI) results in complex cognitive sequelae. Despite hundreds of clinical trials rehabilitation, the translation these findings into practice remains a challenge. Clinical guidelines are one solution. The objective this initiative was reconvene international group researchers and clinicians (known as INCOG) develop INCOG 2.0: Guidelines for Cognitive Rehabilitation Following TBI . Methods: adaptation development cycle used update...
A wide range of diverse and inconsistent terminology exists in the field knowledge translation. This limits conduct evidence syntheses, impedes communication collaboration, undermines translation research findings settings. Improving uniformity could help address these challenges. In 2012, we convened an international working group to explore idea developing a common overarching framework for interventions. Methods included identifying summarizing existing frameworks, mapping together subset...
Introduction: Traumatic brain injury results in complex cognitive sequelae. However, clinicians have difficulty implementing the available evidence. An international group of researchers and (known as INCOG) convened to develop clinical practice guidelines for rehabilitation posttraumatic injury. Methods: The Guidelines Adaptation Development cycle was used derive recommendations. Previously published recommendations were identified tabulated. expert panel met select appropriate Afterward,...
Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...
<h3>Importance</h3> A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown be associated outcomes. mild (mTBI; GCS 13-15), distribution and co-occurrence of pathological their prognostic importance are not well understood. <h3>Objective</h3> To identify adverse outcomes after mTBI....
Complex metabolic disruption is a crucial aspect of the pathophysiology traumatic brain injury (TBI). Associations between this and systemic metabolism their potential prognostic value are poorly understood. Here, we aimed to describe serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, its relationship severity patient outcome. We performed comprehensive metabolomics study in cohort 716 patients non-TBI reference (orthopedic, internal medicine, other...
Abstract Background While the Glasgow coma scale (GCS) is one of strongest outcome predictors, current classification traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormous heterogeneity in pathophysiology and treatment response. We hypothesized that data-driven characterization TBI could identify distinct endotypes give mechanistic insights. Methods developed an unsupervised statistical clustering model a mixture probabilistic graphs for...
Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation traumatic acute subdural hematoma (ASDH) until recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes primary DC craniotomy.We conducted an analysis centre treatment preference within prospective, multicentre, observational Collaborative European NeuroTrauma...
We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs) on brain injury biomarker profiles, acute care requirements during intensive unit (ICU) stay, 6-month outcomes in patients with traumatic (TBI). From recruited to Collaborative European neurotrauma effectiveness research TBI (CENTER-TBI) study, we documented prevalence risk factors for SIs their effect levels biomarkers [S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), neurofilament light...