A5075322672- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Stroke Rehabilitation and Recovery
- Suicide and Self-Harm Studies
- Cerebral Palsy and Movement Disorders
- Sleep and related disorders
- Emergency and Acute Care Studies
- Cognitive Functions and Memory
- Musculoskeletal pain and rehabilitation
- Dementia and Cognitive Impairment Research
- Older Adults Driving Studies
- Psychosomatic Disorders and Their Treatments
- Traffic and Road Safety
- Schizophrenia research and treatment
- Resilience and Mental Health
- Obstructive Sleep Apnea Research
- Posttraumatic Stress Disorder Research
- Injury Epidemiology and Prevention
- Neurobiology of Language and Bilingualism
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Clinical practice guidelines implementation
- Functional Brain Connectivity Studies
Monash University
2016-2025
Epworth Hospital
2016-2025
Australian Regenerative Medicine Institute
2008-2025
Harris Health System
2025
Memorial Hermann Institute for Rehabilitation and Research Foundation
2025
The Alfred Hospital
1999-2023
Marshall Medical Center
2014-2023
McMaster University
2014-2023
The University of Sydney
2014-2023
Parkwood Institute
2014-2023
It is unclear whether decompressive craniectomy improves the functional outcome in patients with severe traumatic brain injury and refractory raised intracranial pressure.From December 2002 through April 2010, we randomly assigned 155 adults diffuse hypertension that was to first-tier therapies undergo either bifrontotemporoparietal or standard care. The original primary an unfavorable (a composite of death, vegetative state, disability), as evaluated on Extended Glasgow Outcome Scale 6...
This study aimed to investigate outcome in adults with mild traumatic brain injury (TBI) at 1 week and 3 months postinjury identify factors associated persisting problems. A total of 84 TBI were compared 53 other minor injuries as controls terms postconcussional symptomatology, behavior, cognitive performance postinjury. At postinjury, reporting symptoms, particularly headaches, dizziness, fatigue, visual disturbance, memory difficulties. They exhibited slowing information processing on...
The deleterious consequences of traumatic brain injury (TBI) impair capacity to return many avenues pre-morbid life. However, there has been limited longitudinal research examining outcome beyond five years post-injury. aim this study was examine aspects function, previously shown be affected following TBI, over a span 10 years. One hundred and forty one patients with TBI were assessed at two, five, post-injury using the Structured Outcome Questionnaire. Fatigue balance problems most common...
Thisstudy examined long-term outcomein traumatically brain-injured individualsfollowing discharge from a comprehensive rehabilitation programme. Of 254 traumatic brain injury (TBI) patients reviewed at 2 years, 103 have been followed up 5 years using structured interview format detailing neurological symptoms, mobility, independence in ADL, productivity status, relationship issues, communication and the presence of cognitive, behavioural emotional changes. Visual difficulties, headache...
ContextPrehospital hypertonic saline (HTS) resuscitation of patients with traumatic brain injury (TBI) may increase survival but whether HTS improves neurological outcomes is unknown.ObjectiveTo determine prehospital intravenous long-term outcome in severe TBI compared conventional fluids.Design, Setting, and PatientsDouble-blind, randomized controlled trial 229 who were comatose (Glasgow Coma Scale score, <9) hypotensive (systolic blood pressure, <100 mm Hg). The enrolled between...
A variety of methods have been used to quantify aspects recovery after anesthesia.Most are narrowly focused, not patient-rated, and validated. We therefore set out develop a patient-rated quality score. constructed 61-item questionnaire that asked individuals (patients relatives, medical nursing staff; total n = 136) rate various postoperative items describing features patient may experience postoperatively. The most highly ranked were included in final nine-point index score, which we...
Abstract Aimed to assess, in the light of current attentional theories, nature deficit a group severely traumatically head-injured subjects, relative orthopaedic rehabilitation patients, and establish which neuropsychological measures best reflected deficit. Three separate studies were conducted order meet these aims. The first study focused on selective attention; second, vigilance or sustained third, Supervisory Attentional System. Results provided no evidence for presence deficits...
Previous investigations of long-term outcome following traumatic brain injury (TBI) have yielded mixed results regarding the predictive power severity and demographic factors. Furthermore, there has been limited investigation association between current cognitive functioning psychiatric state. The aim this study was to investigate severity, factors, concurrent with functional 10 years mild severe TBI. Outcome rated using Extended Glasgow Scale (GOSE) for 60 participants, who also completed...
Many previous studies investigating long-term cognitive impairments following traumatic brain injury (TBI) have focused on extremely severely injured patients, relied subjective reports of change and failed to use demographically relevant control data. The aim this study was investigate 10 years TBI their association with severity. Sixty 43 participants were assessed tests attention, processing speed, memory, executive function. group demonstrated significant impairment measures speed...
There is continuing controversy regarding predictors of poor outcome following mild traumatic brain injury (mTBI). This study aimed to prospectively examine the influence preinjury factors, injury-related and postinjury factors on mTBI.Participants were 123 patients with mTBI 100 trauma patient controls recruited assessed in emergency department followed up 1 week 3 months postinjury. Outcome was measured terms reported postconcussional symptoms. Measures included ImPACT Post-Concussional...
Objectives To retrospectively establish the nature and frequency of Axis I psychiatric disorders pre- post-TBI. Participants One hundred participants who were 0.5 to 5.5 years post mild severe TBI 87 informants, each evaluated at a single time point. Main Measure The Structured Clinical Interview for DSM-IV Disorders (SCID-I). Results Preinjury, 52% received diagnosis, most commonly substance use disorder (41%), followed by major depressive (17%) anxiety (13%). Postinjury, 65% which...
The question as to whether mild traumatic brain injury (mTBI) results in persisting sequelae over and above those experienced by individuals sustaining general trauma remains controversial. This prospective study aimed document outcomes 1 week 3 months post-injury following mTBI assessed the emergency department (ED) of a major adult center. One hundred twenty-three patients presenting with uncomplicated 100 matched controls completed measures post-concussive symptoms cognitive performance...
Introduction: Cognitive-communication disorders are common in individuals with traumatic brain injury (TBI) and can have a major impact on long-term outcome. Guidelines for evidence-informed rehabilitation needed, thus an international group of researchers clinicians (known as INCOG) convened to develop recommendations assessment intervention. Methods: An expert panel met select appropriate treatment cognitive-communication based available literature. To promote implementation, the team...
Introduction: Moderate to severe traumatic brain injury causes significant cognitive impairments, including impairments in social cognition, the ability recognize others' emotions, and infer thoughts. These can have profound negative effects on communication functions, resulting a cognitive-communication disorder. Cognitive-communication disorders significantly limit person's socialize, work, study, thus are critical targets for intervention. This article presents updated INCOG 2.0...
Introduction: Moderate-to-severe traumatic brain injury (MS-TBI) causes debilitating and enduring impairments of executive functioning self-awareness, which clinicians often find challenging to address. Here, we provide an update the INCOG 2014 guidelines for clinical management these impairments. Methods: An expert panel clinicians/researchers (known as INCOG) reviewed evidence published from developed updated recommendations self-awareness post-MS-TBI, well a decision-making algorithm,...
Introduction: Moderate to severe traumatic brain injury (TBI) results in complex cognitive sequelae. Despite hundreds of clinical trials rehabilitation, the translation these findings into practice remains a challenge. Clinical guidelines are one solution. The objective this initiative was reconvene international group researchers and clinicians (known as INCOG) develop INCOG 2.0: Guidelines for Cognitive Rehabilitation Following TBI . Methods: adaptation development cycle used update...
Objective: Evaluate efficacy of cognitive behavioural therapy for sleep and fatigue adapted brain injury relative to health education control in alleviating disturbance after acquired injury. Design: Parallel groups randomized controlled trial. Subjects: 126 community dwelling adults with stroke or traumatic Methods: Participants were 2:1 receive 8-weeks (n = 86) 40). The Pittsburgh Sleep Quality Index was assessed pre- post-treatment, 2 4-months secondary measures insomnia, fatigue,...
<b>Background:</b> The impact of mild head injury is variable and determinants outcome remain poorly understood. Results previous intervention studies have been mixed. <b>Objectives:</b> To evaluate the on provision information, measured in terms reported symptoms, cognitive performance, psychological adjustment three months postinjury. <b>Methods:</b> 202 adults with were studied: 79 assigned to an group assessed one week after injury; 123 a non-intervention control seen at only....
Objectives. The impact of mild head injury or traumatic brain (TBI) in children is variable, and determinants outcome remain poorly understood. There have been no previous attempts to evaluate the interventions improve outcome. Results intervention studies adults mixed. This study aimed providing information on measured terms reported symptoms, cognitive performance, psychological adjustment 3 months after injury. Methods. A total 61 with TBI were assessed 1 week injury, 58 only. They...
A variety of methods have been used to quantify aspects recovery after anesthesia.Most are narrowly focused, not patient-rated, and validated. We therefore set out develop a patient-rated quality score. constructed 61-item questionnaire that asked individuals (patients relatives, medical nursing staff; total n = 136) rate various postoperative items describing features patient may experience postoperatively. The most highly ranked were included in final nine-point index score, which we...