A5090830124- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury Research
- Medical Imaging Techniques and Applications
- Trauma and Emergency Care Studies
- Sleep and Wakefulness Research
- Medical Image Segmentation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- AI in cancer detection
- Motor Control and Adaptation
- Cardiac Arrest and Resuscitation
- Blind Source Separation Techniques
- Optical Imaging and Spectroscopy Techniques
- Neurological disorders and treatments
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Advanced X-ray and CT Imaging
- Sleep and related disorders
- Neurobiology of Language and Bilingualism
Inserm
2012-2025
Concordia University
2016-2025
Assistance Publique – Hôpitaux de Paris
2012-2025
Sunnybrook Health Science Centre
2023-2024
Sunnybrook Research Institute
2023-2024
Concordia University
2017-2023
Concordia University
2017-2023
Sorbonne Université
2011-2021
Pitié-Salpêtrière Hospital
2008-2021
Charité - Universitätsmedizin Berlin
2020
Functional magnetic resonance imaging (fMRI) studies investigating the acquisition of sequential motor skills in humans have revealed learning-related functional reorganizations cortico-striatal and cortico-cerebellar systems accompanied with an initial hippocampal contribution. Yet, significance these activity-level changes remains ambiguous as they convey evolution both sequence-specific knowledge unspecific task ability. Moreover, do not specifically assess occurrence plasticity. To...
In this study, we used functional MRI (fMRI) at high field (3T) to track the time course of activation in entire basal ganglia circuitry, as well other motor-related structures, during explicit learning a sequence finger movements over month training. Fourteen right-handed healthy volunteers had practice 15 min daily eight moves using left hand. sessions were performed on days 1, 14 and 28. both putamen, decreased with rostrodorsal (associative) regions. contrast, there was significant...
Abstract The hippocampus is among the first structures affected in Alzheimer's disease (AD). Hippocampal magnetic resonance imaging volumetry a potential biomarker for AD but hindered by limitations of manual segmentation. We proposed fully automatic method using probabilistic and anatomical priors Probabilistic information derived from 16 young controls knowledge modeled with automatically detected landmarks. results were previously evaluated comparison segmentation on data healthy...
Mindfulness meditation has been shown to promote emotional stability. Moreover, during the processing of aversive and self-referential stimuli, mindful awareness is associated with reduced medial prefrontal cortex (MPFC) activity, a central default mode network (DMN) component. However, it remains unclear whether mindfulness practice influences functional connectivity between DMN regions and, if so, such impact persists beyond state meditation. Consequently, this study examined effect...
This study aimed to investigate, through functional MRI (fMRI), the neuronal substrates associated with consolidation process of two motor skills: sequence learning (MSL) and adaptation (MA). Four groups young healthy individuals were assigned either ( i ) a night/sleep condition, in which they scanned while practicing finger task or an eight-target pointing evening (test) again 12 h later morning (retest) ii day/awake on MSL MA tasks rescanned evening. As expected consistent behavioral...
In Parkinson's disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during that can precede Parkinsonism by several years. The neuronal origin of in disease not precisely known; however, the locus subcoeruleus brainstem has been implicated as this structure blocks normal animal models be damaged disease. Here, we studied integrity coeruleus/subcoeruleus complex patients using combined...
Recent advancements in signal processing and machine learning coupled with developments of electronic medical record keeping hospitals the availability extensive set images through internal/external communication systems, have resulted a recent surge significant interest "Radiomics". Radiomics is an emerging relatively new research field, which refers to extracting semi-quantitative and/or quantitative features from goal developing predictive prognostic models, expected become critical...
Investigating the relationship between brain structure and function is a central endeavor for neuroscience research. Yet, mechanisms shaping this largely remain to be elucidated are highly debated. In particular, existence relative contributions of anatomical constraints dynamical physiological different types established. We addressed issue by systematically comparing functional connectivity (FC) from resting-state magnetic resonance imaging data with simulations increasingly complex...
A recent computational model of brain tumor growth, developed to better describe how gliomas invade through the adjacent parenchyma, is based on two major elements: cell proliferation and isotropic diffusion. On basis this model, glioma growth has been simulated in a virtual brain, provided by 3D segmented MRI atlas. However, it commonly accepted that glial cells preferentially migrate along direction fiber tracts. Therefore, paper, improved including anisotropic extension gliomas. The...
To prospectively evaluate the accuracy of automated hippocampal volumetry to help distinguish between patients with Alzheimer disease (AD), mild cognitive impairment (MCI), and elderly controls, by using established criteria for AD MCI as reference standard.The regional ethics committee approved study written informed consent was obtained from all participants. The included 25 (11 men, 14 women; mean age +/- standard deviation [SD], 73 years 6; Mini-Mental State Examination (MMSE) score,...