A5073443364- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Head and Neck Surgical Oncology
- EEG and Brain-Computer Interfaces
- MRI in cancer diagnosis
- Mathematical Biology Tumor Growth
- Brain Metastases and Treatment
- Neuroscience and Neural Engineering
- Bone Tumor Diagnosis and Treatments
- Advanced MRI Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Medical Imaging Techniques and Applications
- Neural dynamics and brain function
- Cerebrospinal fluid and hydrocephalus
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Vascular Malformations Diagnosis and Treatment
- Neurological disorders and treatments
- Neurofibromatosis and Schwannoma Cases
- Anatomy and Medical Technology
- Intraoperative Neuromonitoring and Anesthetic Effects
Hôpital Lariboisière
2016-2025
Centre National de la Recherche Scientifique
2011-2025
Université Paris Cité
2016-2025
Institut du Cerveau
2017-2025
Inserm
2011-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Sorbonne Université
2009-2024
Pitié-Salpêtrière Hospital
2007-2024
Sorbonne Paris Cité
2015-2024
Hôpital Nord
2024
Despite better knowledge of cortical language organization, its subcortical anatomofunctional connectivity remains poorly understood. The authors used intraoperative stimulation in awake patients undergoing operation for a glioma the left dominant hemisphere to map pathways and determine contribution such method surgical results.One hundred fifteen harboring World Health Organization Grade II within areas underwent after induction local anesthesia, using direct electrical perform online...
Abstract Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics tumor growth before anaplastic transformation. Analysis mean diameters over time showed constant growth. Linear regression, using a model, found an average slope 4.1mm per year (95% confidence interval, 3.8–4.4mm/year). Untreated low‐grade grow continuously during their premalignant phase, and...
The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because actual amount has seldom been assessed.Cases GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 prospectively 1996. Inclusion criteria patient age ≥ 18 years at diagnosis, histological diagnosis GIIG, MRI...
Although advances in diffusion tensor imaging have enabled us to better study the anatomy of inferior longitudinal fasciculus (ILF), its function remains poorly understood. Recently, it was suggested that subcortical network subserving language semantics could be constituted, parallel with occipitofrontal fasciculus, by left ILF, joining posterior occipitotemporal regions temporal pole, then relayed uncinate connecting anterior pole frontobasal areas. Nevertheless, this hypothesis solely...
Diffuse low-grade gliomas are highly epileptogenic brain tumours. We aimed to explore the natural course of epileptic seizures, their predictors and prognostic significance occurrence in adult patients harbouring a diffuse glioma. An observational retrospective multicentre study examined 1509 with identify mutual interactions between tumour characteristics, seizures. At diagnosis, 89.9% had Male gender (P = 0.003) location within functional areas 0.001) were independent history seizures at...
A recent computational model of brain tumor growth, developed to better describe how gliomas invade through the adjacent parenchyma, is based on two major elements: cell proliferation and isotropic diffusion. On basis this model, glioma growth has been simulated in a virtual brain, provided by 3D segmented MRI atlas. However, it commonly accepted that glial cells preferentially migrate along direction fiber tracts. Therefore, paper, improved including anisotropic extension gliomas. The...
A consecutive series of 143 unselected adult patients with histologically proved World Health Organization grade II gliomas was reviewed to assess the prognostic value growth rates mean tumor diameters on successive magnetic resonance images before treatment. There is an inverse correlation between and survival (p < 0.001; median at 5.16 years for a rate 8mm/year or more; >15.0 <8mm/year). Thus, individual imaging should be incorporated in planning initial therapeutic strategy gliomas.
Abstract Objective To evaluate the natural progression and impact of temozolomide in low‐grade gliomas to correlate these changes with profile genetic alterations. Methods The mean tumor diameter (MTD) was evaluated on serial magnetic resonance images before (n = 39), during, after 107) treatment neoadjuvant temozolomide. MTD growth curves were correlated chromosomes 1p‐19q loss p53 overexpression tumors. Results Before onset, increased linearly over time, indicating a continuous that...
Abstract Objective : Seizure is the presenting symptom in most of World Health Organization grade II gliomas (GIIGs). Rarely, a GIIG discovered incidentally on imaging. Little known about natural course and prognosis incidental GIIGs. The aim present study to characterize their history investigate whether clinical radiological behaviors differ from those symptomatic Methods findings, treatments, outcomes 47 histologically‐proven GIIGs were compared with 1249 Results Incidental significantly...
In this study, we investigated the prognostic value of MRI contrast enhancement (CE) at time histological diagnosis specifically in a selected population WHO grade II gliomas. We reviewed 927 histologically proven gliomas for which contrast-enhanced MR images were available diagnosis. CE patterns classified into three categories: "patchy and faint," "nodular-like," "ring-like." progression over was recorded before oncological treatment on successive images, when available. present 143 cases...
Reaction-diffusion based tumor growth models have been widely used in the literature for modeling of brain gliomas. Lately, recent started integrating medical images their formulation. Including different tissue types, geometry and directions white matter fiber tracts improved spatial accuracy reaction-diffusion models. The adaptation general model to specific patient cases on other hand has not studied thoroughly yet. In this paper, we address adaptation. We propose a parameter estimation...
Although diffusion tensor imaging (DTI) and postmortem dissections improved the knowledge of white matter (WM) anatomy, functional information is lacking. Our aims are: to provide a subcortical atlas human brain functions; elucidate roles different bundles; probabilistic resection map WM.We studied 130 patients who underwent awake surgery for gliomas (82 left; 48 right) with electrostimulation mapping at cortical levels. Different aspects language, sensori-motor, spatial cognition, visual...
Supratentorial diffuse low-grade gliomas present a slow macroscopic tumor growth that can be quantified through the measurement of their velocity diametric expansion. We assessed whether spontaneous expansion predict long-term outcomes as categorical variable and continuous predictor.A total 407 adult patients with newly diagnosed supratentorial in adults were studied.The mean before first-line treatment was 5.8 ± 6.3 mm/year. During follow-up (mean, 86.5 59.4 months), 209 presented...
OBJECTIVE Only one phase III prospective randomized study, published in 2006, has assessed the performance of 5-aminolevulinic acid (5-ALA) fluorescence–guided surgery (FGS) for glioblastoma resection. The aim RESECT study was to compare onco-functional results associated with 5-ALA fluorescence and white-light conventional microsurgery patients managed according current standards care. METHODS This a single-blinded involving 21 French neurosurgical centers, comparing FGS care, including...