A5042193970- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Meningioma and schwannoma management
- Cancer-related cognitive impairment studies
- Advanced MRI Techniques and Applications
- Neurobiology of Language and Bilingualism
- Pituitary Gland Disorders and Treatments
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Transcranial Magnetic Stimulation Studies
- Brain Metastases and Treatment
- Fetal and Pediatric Neurological Disorders
- Hemispheric Asymmetry in Neuroscience
- Epilepsy research and treatment
- Spinal Fractures and Fixation Techniques
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Spatial Neglect and Hemispheric Dysfunction
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer survivorship and care
- Mental Health Research Topics
- Cerebrovascular and Carotid Artery Diseases
Elisabeth-TweeSteden Ziekenhuis
2016-2025
Tilburg University
2018-2023
St. Elisabeth Hospital
2014-2019
Université Paris Cité
2017
Assistance Publique – Hôpitaux de Paris
2017
Hôpital Pasteur
2017
Hôpital Lariboisière
2017
Inserm
2017
University Medical Center Utrecht
2001-2007
Utrecht University
2007
Extensive resections in low-grade glioma (LGG) are associated with improved overall survival (OS). However, World Health Organization (WHO) classification of gliomas has been completely revised and is now predominantly based on molecular criteria. This requires reevaluation the impact surgery molecularly defined LGG subtypes.We included 228 adults who underwent since 2003 for a supratentorial LGG. Pre- postoperative tumor volumes were assessed semiautomatic software T2-weighted images....
Meningioma patients are known to face cognitive deficits before and after surgery. We examined individual changes in performance over time identified preoperative predictors of functioning 12 months surgery a large sample meningioma patients.Patients underwent neuropsychological assessment (NPA) using CNS Vital Signs 1 day (T0) 3 (T3) (T12) Patients' sociodemographically corrected scores on 7 domains were compared with normative one-sample z tests chi-square independence. Reliable change...
Many patients with primary brain tumors experience cognitive deficits. Cognitive rehabilitation programs focus on alleviating these deficits, but availability of such is limited. Our large randomized controlled trial (RCT) demonstrated positive effects the program developed by our group. We converted into iPad-based ReMind, to increase its accessibility. The app incorporates psychoeducation, strategy training and retraining. This pilot study in evaluates feasibility use ReMind-app a clinical...
Abstract Background Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating deficits older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an intervention, designed to improve functioning patients, regarding test performance patient-reported outcomes (PROs). Methods Thirty-four clinically stable patients World Health Organization grades II/III were a home-based remotely...
The authors evaluated the cognitive performance of patients with low-grade glioma (LGG) before and after surgery, specifically investigated 1) effects hemispheric tumor location 2) type surgery (either or without intraoperative stimulation mapping [ISM]).
Abstract Previous studies have shown that cognitive functioning in patients with brain tumour is associated the functional network characteristics of specific resting‐state networks or whole‐brain characteristics. These studies, however, did not acknowledge contribution areas contralesional, non‐tumoural hemisphere, even though these healthy remote likely play a critical role compensating for loss function damaged tissue. In current study, we examined whether there an association between...
It has been suggested that internally generated visual perception involves the primary cortex V1. To test this hypothesis, a functional MRI study was conducted with female subject orthographic color–word synesthesia. This selected as she reported clear involuntary visualization of auditorily presented verbal material. Hearing word resulted in seeing particular color. fMRI scans were acquired while performed two tasks (passive listening to words and fluency). Significant activity detected...
Abstract Background Evidence-based cognitive rehabilitation programs for brain tumor patients are not widely available, despite the high need. We aimed to evaluate effects of a tablet-based program on performance, complaints, fatigue, and psychological distress in primary following neurosurgery. Also, attrition, adherence patient satisfaction with were evaluated. Methods Adults presumed low-grade glioma meningioma recruited before surgery. Three months thereafter, participants allocated...
Focal white matter lesions can cause cognitive impairments due to disconnections within or between networks. There is some preliminary evidence that there are specific hubs and fiber pathways should be spared during surgery retain performance. A tract potentially involved in important higher-level processes the frontal aslant tract. It roughly connects posterior parts of inferior gyrus superior gyrus. Functionally, left has been associated with speech right executive functions. However,...
Determining the validity and reliability of a test is crucial when results inform clinical decision-making. Voets et al. highlight priority areas where progress needed to resolve long-standing controversies surrounding applications functional MRI in neurosurgery.
Abstract Introduction Patients with a glioma often suffer from cognitive impairments both before and after anti-tumor treatment. Ideally, clinicians can rely on predictions of post-operative functioning for individual patients based information obtainable surgery. Such would facilitate selecting the optimal treatment considering patients’ onco-functional balance. Method Cognitive three months surgery was predicted 317 across eight tests. Nine multivariate Bayesian regression models were used...
The single diffusion tensor model is inadequate for the reconstruction of fiber pathways in brain regions with multiple orientations. To overcome this limitation, constrained spherical deconvolution has been proposed. A high reliability is, however, a pre‐requisite its use clinical applications. Reliability reconstructed can be assessed terms architectural (addressing their spatial configuration) and microstructural diffusion‐derived measures along fibers) reproducibility. We assess two...
Imaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials the field DLGG, we aimed status quo within specialized European centers.An online survey composed 46 items was sent out members Low-Grade Glioma Network, Association Neurosurgical Societies, German Society Neurosurgery Austrian Neurosurgery.A total 128 fully completed surveys were received analyzed. Most centers (n =...
This study aimed to examine: (1) patient-proxy agreement on executive functioning (EF) of patients with primary brain tumors, (2) the relationships between patient- and proxy-report performance-based measures EF, (3) potential influence level agreement.Meningioma low-grade glioma their informal caregivers completed Behavior Rating Inventory Executive Function (BRIEF-A) 3 months after surgery. The two index scores BRIEF-A, Behavioral Regulation Metacognition, were evaluated. Mean proxies...
Progressive disease in patients with high-grade glioma may be reflected cognitive decline. However, the functions most sensitive to progression differ between patients. We investigated whether decline on a personalized selection of tests predicted progressive according RANO criteria patients.Starting one day before surgery, underwent neuropsychological assessment every three months during standard treatment and clinical follow-up. first made that showed highest Reliable Change Index (RCI)...
Direct electrical stimulation mapping was used to map executive functions during awake surgery of a patient with right frontal low-grade glioma. We specifically targeted the aslant tract, as this pathway had been infiltrated by tumor. The tract has implicated in neuroscientific literature, but is yet unknown relevance for clinical practice. Guided tractography, disrupted working memory and inhibitory functions. In report we illustrate dilemmas that neurosurgeons face when balancing maximal...
Abstract Background People with gliomas need specialized neurosurgical, neuro-oncological, psycho-oncological, and neuropsychological care. The role of language cognitive recovery rehabilitation in patients’ well-being resumption work is crucial, but there are no clear guidelines for the ideal timing character assessments interventions. goal present was to describe representative (neuro)psychological practices implemented after brain surgery Europe. Methods An online survey addressed...
Ample reports highlight fMRI’s added value to guide neurosurgical interventions near brain regions supporting speech and language. However, usefulness for clinical language mapping remains controversial, partly fueled by 1) differences from standard tools it is often compared against, 2) wide heterogeneity in how data are acquired, analyzed interpreted. Both factors limit objective assessment of the benefits efficacy presurgical fMRI. This underscores need standardization fMRI protocols...
The objective of this study was presurgical assessment reorganization motor hand function in an 11-year-old girl with intractable epilepsy and a right-sided hemiplegia resulting from extensive perinatal left hemispheric stroke. Prior to functional hemispherectomy, magnetic resonance imaging (MRI) showed that both nonparetic paretic predominantly activated the right primary cortex, whereas no activation found hemisphere. Transcranial stimulation central area yielded responses hand, were...