Jagoš Golubović
A5024742253- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Surgical Simulation and Training
- Hip and Femur Fractures
- Vascular Malformations Diagnosis and Treatment
- Radiation Dose and Imaging
- Meningioma and schwannoma management
- Spine and Intervertebral Disc Pathology
- Simulation-Based Education in Healthcare
- Emergency and Acute Care Studies
- Health Systems, Economic Evaluations, Quality of Life
- Global Health and Surgery
- Cervical and Thoracic Myelopathy
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Respiratory Support and Mechanisms
- Glioma Diagnosis and Treatment
- Autopsy Techniques and Outcomes
- Posttraumatic Stress Disorder Research
University of Novi Sad
2016-2025
Klinički centar Vojvodine
2015-2025
University of Groningen
2022
Karolinska Institutet
2022
University Hospital Heidelberg
2021
Heidelberg University
2021
Oslo University Hospital
2021
University of Oslo
2021
University Hospital of North Norway
2021
Medical University of Vienna
2021
ObjectiveWe aimed to explore the added value of common machine learning (ML) algorithms for prediction outcome moderate and severe traumatic brain injury.Study Design SettingWe performed logistic regression (LR), lasso regression, ridge with key baseline predictors in IMPACT-II database (15 studies, n = 11,022). ML included support vector machines, random forests, gradient boosting artificial neural networks were trained using same predictors. To assess generalizability predictions, we...
Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...
<h3>Importance</h3> A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown be associated outcomes. mild (mTBI; GCS 13-15), distribution and co-occurrence of pathological their prognostic importance are not well understood. <h3>Objective</h3> To identify adverse outcomes after mTBI....
Complex metabolic disruption is a crucial aspect of the pathophysiology traumatic brain injury (TBI). Associations between this and systemic metabolism their potential prognostic value are poorly understood. Here, we aimed to describe serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, its relationship severity patient outcome. We performed comprehensive metabolomics study in cohort 716 patients non-TBI reference (orthopedic, internal medicine, other...
Abstract Background While the Glasgow coma scale (GCS) is one of strongest outcome predictors, current classification traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormous heterogeneity in pathophysiology and treatment response. We hypothesized that data-driven characterization TBI could identify distinct endotypes give mechanistic insights. Methods developed an unsupervised statistical clustering model a mixture probabilistic graphs for...
Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation traumatic acute subdural hematoma (ASDH) until recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes primary DC craniotomy.We conducted an analysis centre treatment preference within prospective, multicentre, observational Collaborative European NeuroTrauma...
We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs) on brain injury biomarker profiles, acute care requirements during intensive unit (ICU) stay, 6-month outcomes in patients with traumatic (TBI). From recruited to Collaborative European neurotrauma effectiveness research TBI (CENTER-TBI) study, we documented prevalence risk factors for SIs their effect levels biomarkers [S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), neurofilament light...
In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting too early could result death despite the possibility an acceptable functional outcome, whereas delaying unnecessarily burden patients, families, clinicians, and hospital resources. We aimed to describe occurrence timing WLSM, factors associated European ICUs traumatic injury (TBI). The CENTER-TBI Study prospective multi-center...
Men and women differ in outcomes following mild traumatic brain injury (TBI). In the CENTER-TBI study, we previously found that had worse 6-month functional outcome (Glasgow Outcome Score Extended (GOSE)), health-related quality of life (HRQoL), mental health TBI. The aim this study was to investigate whether those differences were mediated by psychiatric history, gender- related sociodemographic variables, or care pathways. We analyzed sex/gender GOSE, generic TBI-specific HRQoL,...
Importance Exposure to traumatic brain injury (TBI) has raised widespread concern over participation in sports, particularly possible long-term consequences. However, little is known about the outcomes of individuals presenting hospitals with sports-related TBI. Objective To compare characteristics and non–sports-related Design, Setting, Participants The CENTER-TBI (Collaborative European NeuroTrauma Effectiveness Research TBI) observational cohort study was conducted at 18 countries....
The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score 13-15. Prognostic models that were developed predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed validate predicting 3-12-month Outcome Extended (GOSE) or PPCS in adults with TBI. analyzed data from the Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury...
OBJECTIVE The aim of this study was to compare the outcomes early (≤ 90 days) and delayed (> cranioplasty following decompressive craniectomy (DC) in patients with traumatic brain injury (TBI). METHODS authors analyzed participants enrolled Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) Neurotraumatology Quality Registry (Net-QuRe) studies who were diagnosed TBI underwent DC subsequent cranioplasty. These prospective, multicenter,...
The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate severe traumatic brain (TBI). We aimed to assess their performance a contemporary cohort patients across Europe. Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) core study is prospective, observational presenting with TBI an indication for...
Abstract Background Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated high rates of complications, unfavourable outcomes and mortality. The mechanism the development TBI-associated poorly understood. Methods This analysis, embedded prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise TBI. Emphasis was placed on acute phase following TBI,...
Because nearly 23,000 more neurosurgeons are needed globally to address 5 million essential neurosurgical cases that go untreated each year, there is an increasing interest in task-shifting and task-sharing (TS/S), delegating tasks nonspecialists, particularly low- middle-income countries (LMICs). This global survey aimed provide a cross-sectional understanding of the prevalence structure current TS/S practices LMICs.
An increasing number of elderly patients are being affected by traumatic brain injury (TBI) and a significant proportion on pre-hospital antithrombotic therapy for cardio- or cerebrovascular indications. We have quantified the impact antiplatelet/anticoagulant (APAC) agents radiological lesion progression in acute TBI, using novel, semi-automated approach to volumetric measurement, explored use clinical outcomes Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury...
We aimed to study the associations between pre- and in-hospital tracheal intubation outcomes in traumatic brain injury (TBI), whether association varied according severity.Data from international prospective pan-European cohort study, Collaborative European NeuroTrauma Effectiveness Research for TBI (CENTER-TBI), were used (n=4509). For prehospital intubation, we excluded self-presenters. patients whose tracheas intubated on-scene excluded. The outcome was analysed with ordinal regression...
In medical research, missing data is common. acute diseases, such as traumatic brain injury (TBI), even well-conducted prospective studies may suffer from in baseline characteristics and outcomes. Statistical models simply drop patients with any values, potentially leaving a selected subset of the original cohort. Imputation widely accepted by methodologists an appropriate way to deal data. We aim provide practical guidance on handling for prediction modeling. hereto propose five-step...