A5070231139- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury Research
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Medical Image Segmentation Techniques
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Radiation Dose and Imaging
- Cardiac Arrest and Resuscitation
- Neurofibromatosis and Schwannoma Cases
- Bone and Joint Diseases
- Medical Imaging and Analysis
- Brain Tumor Detection and Classification
- Radiomics and Machine Learning in Medical Imaging
- Parathyroid Disorders and Treatments
- Brain Metastases and Treatment
- Infectious Diseases and Tuberculosis
- Acute Ischemic Stroke Management
- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Salivary Gland Tumors Diagnosis and Treatment
- Radiology practices and education
- Management of metastatic bone disease
- Domain Adaptation and Few-Shot Learning
Cambridge University Hospitals NHS Foundation Trust
2015-2024
Addenbrooke's Hospital
2011-2024
Icahn School of Medicine at Mount Sinai
2024
University of Cambridge
2003-2023
Bridge University
2021
Bedford Hospital
2021
National Health Service
2016
Royal Berkshire NHS Foundation Trust
2007
New College
2003
We examined optokinetic and optomotor responses of 450 zebrafish mutants, which were isolated previously based on defects in organ formation, tissue patterning, pigmentation, axon guidance, or other visible phenotypes. These strains carry single point mutations >400 essential loci. asked fraction the mutants develop blindness types impairments specific to visual system. Twelve failed respond either one both our assays. Subsequent histological electroretinographic analysis revealed unique...
BackgroundCT is the most common imaging modality in traumatic brain injury (TBI). However, its conventional use requires expert clinical interpretation and does not provide detailed quantitative outputs, which may have prognostic importance. We aimed to deep learning reliably efficiently quantify detect different lesion types.MethodsPatients were recruited between Dec 9, 2014, 17, 2017, 60 centres across Europe. trained validated an initial convolutional neural network (CNN) on manual...
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms common, seemingly unrelated to severity. The true frequency underlying mechanisms of injury are unknown, but exaggerated host inflammatory responses appear be key driver We investigated the dynamics of, relationship between, serum markers brain [neurofilament light (NfL), glial fibrillary acidic protein (GFAP) total tau]...
Modern management of MS targets No Evidence Disease Activity (NEDA): no clinical relapses, magnetic resonance imaging (MRI) disease activity and disability worsening. While MRI is the principal tool available to neurologists for monitoring clinically silent and, where appropriate, escalating treatment, standard radiology reports are qualitative may be insensitive development new or enlarging lesions. Existing quantitative neuroimaging tools lack adequate validation. In 397 multi-center scan...
BackgroundWe aimed to understand the relationship between serum biomarker concentration and lesion type volume found on computed tomography (CT) following all severities of TBI.MethodsConcentrations six biomarkers (GFAP, NFL, NSE, S100B, t-tau UCH-L1) were measured in samples obtained <24 hours post-injury from 2869 patients with TBI, enrolled CENTER-TBI prospective cohort study (NCT02210221). Imaging phenotypes defined as intraparenchymal haemorrhage (IPH), oedema, subdural haematoma (SDH),...
Accurate and precise measurement of vestibular schwannoma (VS) size is key to clinical management decisions. Linear measurements are used in routine practice but prone error. This study aims compare a semi-automated volume segmentation tool against standard linear method for measuring small VS. also examines whether oblique tumour orientation can contribute Experimental comparison observer agreement using two techniques. Tertiary skull base unit. Twenty-four patients with unilateral sporadic...
Persistent symptoms after mild traumatic brain injury (mTBI) represent a major public health problem.To identify neuroanatomical substrates of mTBI and the optimal timing for magnetic resonance imaging (MRI).This prospective multicenter cohort study encompassed all eligible patients from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) (December 19, 2014, to December 17, 2017) local (November 20, 2012, 2013). Patients presented hospital within...
Metabolic derangements following traumatic brain injury are poorly characterized. In this single-centre observational cohort study we combined 18F-FDG and multi-tracer oxygen-15 PET to comprehensively characterize the extent spatial pattern of metabolic derangements. Twenty-six patients requiring sedation ventilation with intracranial pressure monitoring head within a Neurosciences Critical Care Unit, 47 healthy volunteers were recruited. Eighteen excluded for age over 60 years (n = 11),...
BackgroundEven patients with normal computed tomography (CT) head imaging may experience persistent symptoms for months to years after mild traumatic brain injury (mTBI). There is currently no good way predict recovery and triage who benefit from early follow-up targeted intervention. We aimed assess if existing prognostic models can be improved by serum biomarkers or diffusion tensor metrics (DTI) MRI, identify DTI.MethodsWe included 1025 aged >18 a Glasgow Coma Score >12 CT the...
Difficulties with attention are common following stroke, particularly in patients frontal and parietal damage, associated poor outcome. Home-based online cognitive training may have the potential to provide an efficient effective way improve attentional functions such patients. Little work has been carried out assess efficacy of this approach stroke patients, lack studies active control conditions rigorous evaluations functioning pre post-training means understanding is limited as whether...
Cognitive disturbances occur early in Huntington's disease (HD) and place a significant burden on the lives of patients family members. Whilst these impairments are typically attributed to deterioration frontal-striatal pathways, accumulating evidence suggests that hippocampal dysfunction may also contribute such impairments. Here, we employ novel spatial memory task has previously been shown elicit individuals with focal lesions, as means further investigate role HD. Sixty-four participated...
Background and Purpose- Cerebral autosomal dominant arteriopathy with subcortical infarcts leukoencephalopathy (CADASIL) is the most common monogenic form of stroke usually presenting migraine aura, lacunar infarcts, cognitive impairment. Acute encephalopathy a less recognized presentation disease. Methods- Data collected prospectively from 340 consecutively recruited symptomatic patients diagnosis CADASIL seen in British National clinic was retrospectively reviewed original clinical records...
An increasing number of elderly patients are being affected by traumatic brain injury (TBI) and a significant proportion on pre-hospital antithrombotic therapy for cardio- or cerebrovascular indications. We have quantified the impact antiplatelet/anticoagulant (APAC) agents radiological lesion progression in acute TBI, using novel, semi-automated approach to volumetric measurement, explored use clinical outcomes Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury...
<h3>BACKGROUND AND PURPOSE:</h3> Lacunar infarcts account for approximately 25% of acute ischemic strokes. Compared with NCCT alone, the addition CTP improves sensitivity detection overall. Our aim was to systematically evaluate diagnostic benefit and interobserver reliability an incremental CT protocol in lacunar infarction. <h3>MATERIALS METHODS:</h3> Institutional review board approval patient consent were obtained. One hundred sixty-three patients presenting a syndrome ≤4.5 hours from...
Abstract Intrathyroidal parathyroid adenomas (IPAs) are a rare cause of primary hyperparathyroidism. They often difficult to localize preoperatively and intraoperatively, making diagnosis treatment challenging. Current data on IPAs sparse fragmented in the literature. This makes it compare effectiveness different imaging surgical techniques. To address this issue, scoping review maps literature IPAs, focusing four domains: clinical presentation, current localization methods, techniques,...