Audny Anke
A5081430897- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Musculoskeletal pain and rehabilitation
- Stroke Rehabilitation and Recovery
- Emergency and Acute Care Studies
- Down syndrome and intellectual disability research
- Sepsis Diagnosis and Treatment
- Chronic Disease Management Strategies
- Acute Ischemic Stroke Management
- Cerebral Palsy and Movement Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Spine and Intervertebral Disc Pathology
- Cerebrospinal fluid and hydrocephalus
- Injury Epidemiology and Prevention
- Botulinum Toxin and Related Neurological Disorders
- Family and Patient Care in Intensive Care Units
- Adolescent and Pediatric Healthcare
- Health, psychology, and well-being
- S100 Proteins and Annexins
- Neurosurgical Procedures and Complications
- Hip and Femur Fractures
- Radiation Dose and Imaging
- Fibromyalgia and Chronic Fatigue Syndrome Research
University Hospital of North Norway
2016-2025
UiT The Arctic University of Norway
2016-2025
University of Oslo
1997-2025
University of Cambridge
2023-2024
Posten (Norway)
2020-2024
University of Parma
2024
Addenbrooke's Hospital
2024
AGH University of Krakow
2023
Wrocław University of Science and Technology
2023
Oslo University Hospital
2020-2022
ObjectiveWe aimed to explore the added value of common machine learning (ML) algorithms for prediction outcome moderate and severe traumatic brain injury.Study Design SettingWe performed logistic regression (LR), lasso regression, ridge with key baseline predictors in IMPACT-II database (15 studies, n = 11,022). ML included support vector machines, random forests, gradient boosting artificial neural networks were trained using same predictors. To assess generalizability predictions, we...
<b>Objective</b> To assess the efficacy of caudal epidural steroid or saline injection in chronic lumbar radiculopathy short (6 weeks), intermediate (12 and long term (52 weeks). <b>Design</b> Multicentre, blinded, randomised controlled trial. <b>Setting</b> Outpatient multidisciplinary back clinics five Norwegian hospitals. <b>Participants</b> Between October 2005 February 2009, 461 patients assessed for inclusion (presenting with >12 328 excluded cauda equina syndrome, severe paresis,...
Abstract Objective To assess the efficacy of three months antibiotic treatment compared with placebo in patients chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes). Design Double blind, parallel group, controlled, multicentre trial. Setting Hospital outpatient clinics at six hospitals Norway. Participants 180 type 1 (n=118) or 2 (n=62) Modic enrolled from June 2015 to September 2017. Interventions Patients were randomised oral either 750 mg...
Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...
<h3>Importance</h3> A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown be associated outcomes. mild (mTBI; GCS 13-15), distribution and co-occurrence of pathological their prognostic importance are not well understood. <h3>Objective</h3> To identify adverse outcomes after mTBI....
Complex metabolic disruption is a crucial aspect of the pathophysiology traumatic brain injury (TBI). Associations between this and systemic metabolism their potential prognostic value are poorly understood. Here, we aimed to describe serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, its relationship severity patient outcome. We performed comprehensive metabolomics study in cohort 716 patients non-TBI reference (orthopedic, internal medicine, other...
Abstract Background While the Glasgow coma scale (GCS) is one of strongest outcome predictors, current classification traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormous heterogeneity in pathophysiology and treatment response. We hypothesized that data-driven characterization TBI could identify distinct endotypes give mechanistic insights. Methods developed an unsupervised statistical clustering model a mixture probabilistic graphs for...
Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...
Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation traumatic acute subdural hematoma (ASDH) until recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes primary DC craniotomy.We conducted an analysis centre treatment preference within prospective, multicentre, observational Collaborative European NeuroTrauma...
CPPopt denotes a Cerebral Perfusion Pressure (CPP) value at which the Pressure-Reactivity index, reflecting global state of Autoregulation, is best preserved. has been investigated as potential dynamically individualised CPP target in traumatic brain injury patients admitted intensive care unit. The prospective bedside use concept requires ensured safety and reliability recommended targets based on automatically-generated CPPopt. We aimed to: Increase stability automated algorithm by...
A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below individual lower limit reactivity (LLR) is associated mortality in traumatic brain injury (TBI) patients. We aim to validate this a large multicentre cohort.Recordings from 171 TBI patients high-resolution cohort CENTER-TBI were processed ICM+ software. derived LLR as trend CPP at level for which index (PRx) indicates impaired cerebrovascular low CPP. The...
We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs) on brain injury biomarker profiles, acute care requirements during intensive unit (ICU) stay, 6-month outcomes in patients with traumatic (TBI). From recruited to Collaborative European neurotrauma effectiveness research TBI (CENTER-TBI) study, we documented prevalence risk factors for SIs their effect levels biomarkers [S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), neurofilament light...
Importance Exposure to traumatic brain injury (TBI) has raised widespread concern over participation in sports, particularly possible long-term consequences. However, little is known about the outcomes of individuals presenting hospitals with sports-related TBI. Objective To compare characteristics and non–sports-related Design, Setting, Participants The CENTER-TBI (Collaborative European NeuroTrauma Effectiveness Research TBI) observational cohort study was conducted at 18 countries....
Purpose The Norwegian Neck and Back Registry (Norsk Nakke og Rygg Register, NNRR) was established to improve the quality of diagnosis treatment in patients with neck back complaints at Departments Physical Medicine Rehabilitation (PMR) hospitals. purpose this cohort profile is describe data from registered 2016 2022 linkage opportunities. Participants registry includes adult referred PMR multidisciplinary outpatient clinics As 2022, more than 8000 men 10 000 women are included registry....
The prevalence of impairments and disabilities in activities daily living (ADL), nonwork activities, work were registered a consecutive series (n = 69) subjects with severe injuries. At follow-up 3 years after trauma, residual prevailed 80%. Only few (6%) ADL-dependent. Seventy-six percent had lost at least one activity, while vocational disability caused by the trauma occurred 19%. Cognitive impairment was significantly associated disability, physical pain disability. Other parameters that...
<b><i>Aims:</i></b> The aims of this study were to assess the incidence hospital-admitted severe traumatic brain injury (TBI) in adult population Norway, and determine whether there differences epidemiological characteristics TBI between rural urban regions. <b><i>Methods:</i></b> A prospective population-based on adults with admitted Norwegian Trauma Referral Centres during 2-year period (2009–2010). electronic patient register was searched...
To confirm the reliability and diagnostic validity of JFK Coma Recovery Scale-Revised (CRS-R) across raters with varying levels experience.Thirty-one patients disorders consciousness were recruited from 6 Norwegian hospitals.CRS-R Disability Rating Scale.Reliability measures good for CRS-R total scores moderate to its subscales. Diagnostic agreement among examiners was good. Raters' experience favorably influenced reliability. Sensitivity specificity analyses demonstrated better detection in...
To assess the effect of arm motor impairment on actual use in early post-stroke period and explore its association with self-care dependency.Thirty-one patients recruited within 30 first days after stroke.Motor upper extremity was measured Fugl-Meyer Motor Assessment (FMA) accelerometry. Arm movement ratio (AMR), duration between more less affected arm, calculated. Self-care dependency defined as needing personal assistance primary activities.FMA strongly associated AMR (Spearman's...
Objectives: To assess burden in the caregivers of patients with severe traumatic brain injury (TBI) 1 year postinjury, related to caregiver's demographic data and social network, patient's data, severity, functional status. Design: Prospective national multicenter study. Self-report from caregivers, patient collected cohort on TBI. Participants: 92 caregivers. Main outcome measure: The Caregiver Burden Scale (CBS). Results: Total caregiver was reported high 16% moderate 34%. mean total index...
Cerebral autoregulation, as measured using the pressure reactivity index (PRx), has been related to global patient outcome in adult patients with traumatic brain injury (TBI). To date, this documented without accounting for standard baseline admission characteristics and intracranial (ICP). We evaluated association, adjusting ICP, a multi-center, prospective cohort. derived PRx correlation between ICP mean arterial prospectively collected multi-center data from High-Resolution Intensive Care...