Sophie Richter
A5050096661- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Respiratory Support and Mechanisms
- Neurosurgical Procedures and Complications
- Plant Pathogens and Fungal Diseases
- Radiation Dose and Imaging
- S100 Proteins and Annexins
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Plant Physiology and Cultivation Studies
- Functional Brain Connectivity Studies
- Employment and Welfare Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Yeasts and Rust Fungi Studies
- Autopsy Techniques and Outcomes
University of Cambridge
2019-2025
Addenbrooke's Hospital
2016-2025
Cambridge University Hospitals NHS Foundation Trust
2016-2025
University of South Australia
2024
Julius Kühn-Institut
2024
Leibniz University Hannover
2024
University of Groningen
2022
Karolinska Institutet
2022
Radboud University Nijmegen
2020-2021
Radboud University Medical Center
2021
Serum biomarkers may inform and improve care in traumatic brain injury (TBI). We aimed to correlate serum with clinical severity, path imaging abnormalities TBI, explore their incremental value over characteristics predicting computed tomographic (CT) abnormalities.
Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...
The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, are underrepresented TBI research. Therefore, we aimed to provide an overview health-care utilization, and six-month outcomes after their determinants who sustained TBI.We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. In-hospital post-hospital care utilization were...
Persistent symptoms after mild traumatic brain injury (mTBI) represent a major public health problem.To identify neuroanatomical substrates of mTBI and the optimal timing for magnetic resonance imaging (MRI).This prospective multicenter cohort study encompassed all eligible patients from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) (December 19, 2014, to December 17, 2017) local (November 20, 2012, 2013). Patients presented hospital within...
The growth in multi-center neuroimaging studies generated a need for methods that mitigate the differences hardware and acquisition protocols across sites i.e., scanner effects. ComBat harmonization have shown promise but not yet been tested on all data types commonly studied with magnetic resonance imaging (MRI). This study aimed to validate neuroCombat, longCombat gamCombat both structural diffusion metrics cross-sectional longitudinal data. We used travelling subject design whereby 73...
Abstract Background Operations Management meetings in NHS hospitals provide an opportunity for operational and clinical staff to monitor demand capacity manage patient flow. These play important role the achievement of resilient performance over time. However, little is known about work that takes place within these United Kingdom’s National Health Service. Methods We conducted a qualitative study observing 29 across three English between June October 2023. The observations focused on: who...
To compare the acute and 6 month outcome of catheter ablation atrial fibrillation (AF) using irrigated tip magnetic remote cathter navigation (RMN) with manual (MCN) in patients paroxysmal persistent AF.In this retrospective analysis 356 (235 male, mean age: 57.9 ± 10.9 years) AF (70.5%, paroxysmal) who underwent between August 2007 May 2008 either RMN (n = 70, 46 10.1 years, 50% or MCN 286, 189 58.0 13.9 75.5% were included. All completed an intensive follow-up strategy. Complete pulmonary...
AimsThe safety and efficacy of novel oral anticoagulants in patients with atrial fibrillation undergoing pacemaker or implantable cardioverter-defibrillator interventions have not been clearly defined. Therefore, we compared the incidence bleeding thrombo-embolic complications following cardiac rhythm device (CRD) implantations under dabigatran vs. rivaroxaban a real-world cohort.
Prognostication is challenging in patients with traumatic brain injury (TBI) whom computed tomography (CT) fails to fully explain a low level of consciousness. Serum biomarkers reflect the extent structural damage different way than CT does, but it unclear whether provide additional prognostic value across range abnormalities. This study aimed determine added predictive biomarkers, differentiated by imaging severity. used data from Collaborative European NeuroTrauma Effectiveness Research...
Mild traumatic brain injury is a common presentation to the emergency department, with current management often focusing on determining whether patient requires CT head scan and/or neurosurgical intervention. There growing appreciation that approximately 20%-40% of patients, including those negative (normal) CT, will develop ongoing symptoms for months years, termed post-concussion syndrome. Owing requirement improved diagnostic and prognostic mechanisms, there has been increasing evidence...
In the course of evaluation five patients with left atrial myxoma, it was noted that movement myxoma related to specific changes in hemodynamics. Prolapsing tumors, Type I, move from ventricle atrium early systole and diastole, thereby causing prominent c v waves accompanied by a rapid y descent. Nonprolapsing II, remain during entire cardiac cycle, impeding flow across mitral valve. these latter cases, descent is slow indistinguishable caused valvular stenosis. The cineangiocardiograms...
The prediction of functional outcome after mild traumatic brain injury (mTBI) is challenging. Conventional magnetic resonance imaging (MRI) does not do a good job explaining the variance in outcome, as many patients with incomplete recovery will have normal-appearing clinical neuroimaging. More advanced quantitative techniques such diffusion MRI (dMRI), can detect microstructural changes otherwise visible, and so may offer way to improve prediction. In this study, we explore potential linear...
The purpose of this study was to measure regional contractile function in the normal rat using cardiac cine and tagged cardiovascular magnetic resonance (CMR) during incremental low doses dobutamine at rest. Five rats were investigated for invasive left ventricle pressure measurements five additional imaged on a clinical 1.5 T MR system sequence (11–20 phases per cycle, 0.28/0.28/2 mm) C-SPAMM tag (18–25 0.63/1.79/3 mm, spacing 1.25 mm). For each slice, wall thickening (WT) circumferential...
Abstract Background Magnetic resonance imaging (MRI) carries prognostic importance after traumatic brain injury (TBI), especially when computed tomography (CT) fails to fully explain the level of unconsciousness. However, in critically ill patients, risk deterioration during transfer needs be balanced against benefit detecting prognostically relevant information on MRI. We therefore aimed assess if day serum protein biomarkers could identify TBI patients whom risks are compensated by...
There is little consensus on the best way to measure emergency department (ED) crowding. We have previously developed a consensus-based measure, International Crowding Measure in Emergency Departments. aimed externally validate short form of Department (sICMED) against physician's perceptions crowding and danger.We performed an observational validation study seven EDs five different countries. recorded sICMED observations most senior available danger at same time. times series regression...
Objectives & Background Emergency department crowding is a serious public health problem throughout the developed world. In 2015 UK Royal College of Medicine was charged by its executive with producing toolkit to reduce crowding. This study commissioned inform said toolkit. The goal develop list interventions deal and exit block, based on consensus group senior emergency physicians. Methods Delphi technique used undertake formal blinded study. 33 experts were invited. These committee...