A5019496775- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Respiratory Support and Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and Diving-Related Complications
- Cerebrospinal fluid and hydrocephalus
- Radiation Dose and Imaging
- Autopsy Techniques and Outcomes
- Cerebral Venous Sinus Thrombosis
- Bone and Joint Diseases
- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Emergency and Acute Care Studies
- Ultrasound in Clinical Applications
- Resilience and Mental Health
- Cardiac Imaging and Diagnostics
- Palliative Care and End-of-Life Issues
Norwegian University of Science and Technology
2014-2025
St Olav's University Hospital
2014-2024
University of Cambridge
2022-2024
Addenbrooke's Hospital
2022-2024
Erasmus MC
2020-2023
Sunnaas sykehus
2022
Stiftung Liebenau (Germany)
2022
Integra LifeSciences (United States)
2022
Hutchinson (United Kingdom)
2022
KU Leuven
2022
It has recently been suggested that the degree of intracranial pressure (ICP) above treatment goal can be estimated by area under curve (AUC) ICP versus time in patients with severe traumatic brain injury (TBI). The objective this study was to determine whether calculated "ICP dose"-the AUC-is related mortality rate, outcome, and Marshall CT classification.Of 135 (age range 1-82 years) TBI treated during a 5-year period at authors' institution, 113 underwent monitoring (84%). Ninety-three...
In this prospective cohort study the authors examined patients with moderate to severe head injuries using MR imaging in early phase. The objective was explore occurrence of diffuse axonal injury (DAI) and determine whether DAI related level consciousness patient outcome.One hundred fifty-nine (age range 5-65 years) traumatic brain injury, who survived acute phase, had a Glasgow Coma Scale (GCS) score 3-13 were admitted between October 2004 August 2008. Of these 159 patients, 106 within 4...
To study overall survival (OS), prognostic factors, and repeated surgery in glioblastoma multiforme (GBM).Retrospective of 516 consecutive adult patients who underwent primary for a GBM year 2003-2008.Median age at was 63.7 years (range 18.0-88.0). Median OS 9.9 months. Age > 60 years, poor preoperative ECOG score, bilateral tumor, biopsy rather than resection, no temozolomide chemoradiotherapy were negative risk factors. Repeat performed 65 (13%). time between first second 7 Indications...
The aim of this study was to explore the prognostic value visible traumatic axonal injury (TAI) loads in different MRI sequences from early phase after adjusting for established factors. Likewise, we sought role apparent diffusion coefficient (ADC) values normal-appearing corpus callosum. In prospective study, 128 patients (mean age, 33.9 years; range, 11–69) with moderate (n = 64) and severe brain (TBI) were examined at a median 8 days (range, 0–28) postinjury. TAI lesions fluid-attenuated...
<h3>Objective</h3> To study the evolution of traumatic axonal injury (TAI) detected by structural MRI in patients with moderate and severe brain (TBI) during first year relate findings to outcome. <h3>Methods</h3> 58 TBI (Glasgow Coma Scale score 3–13) were examined at a median 7 days, 3 months 12 post injury. TAI lesions evaluated blinded categorised into three stages based on location: hemispheres, corpus callosum brainstem. Lesions T2* weighted gradient echo (GRE), fluid attenuated...
Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and successive morbidity. In mild TBI (mTBI), however, the extent persistence of innate are unknown. We determined plasma cytokine level changes over 12 months after an mTBI hospitalized non-hospitalized patients compared with community controls; examined their associations to injury-related demographic variables at admission. Prospectively, 207 presenting emergency department (ED) or general practitioner...
Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...
The morbidity and mortality of subarachnoid hemorrhage (SAH) are high, established risk factors scarce. We prospectively assessed the association blood pressure, smoking, body mass with aneurysmal SAH.All residents >or=20 years were invited to Nord-Trøndelag Health (HUNT) Study (1984 1986) 74,977 (88.1%) attended. study included standardized measurements weight height, self-administered questionnaires. Participants who later had SAH (n=132) identified, hazard ratios (HRs), adjusted for age...
Background: In patients with severe head injury, control of physiological variables is important to avoid intracranial hypertension and secondary injury the brain. The aims this retrospective study were evaluate deviations incidence extracranial complications in injury. We also studied if these could be related outcome. Patients methods: One hundred thirty‐three included during a 5‐year period (1998–2002). Deviations from treatment goals for following studied: blood pressure, haemoglobin,...
Objective: The incidence of aneurysmal subarachnoid hemorrhage (aSAH) ranges from 4 to 10 per 100,000 person-years in most countries, and 30-day case fatality is high. aim this study was estimate the aSAH assess preictal predictors survival 2 large Norwegian population-based cohort studies. Methods: A total 94,976 adults (≥20 years) Nord-Trøndelag Health Study 31,753 participants (aged ≥20 Tromsø were included. During follow-up, aSAHs identified, rates estimated, assessed using Cox Poisson...
The objectives of this prospective study in 62 moderate–severe TBI patients were to investigate volume change cortical gray matter (GM), hippocampus, lenticular nucleus, lobar white (WM), brainstem and ventricles using a within subject design repeated MRI the early phase (1–26 days) 3 12 months postinjury assess changes GM apparent diffusion coefficient (ADC) normal appearing tissue cortex, hippocampus brainstem. impact Glasgow Coma Scale (GCS) score at admission, duration post-traumatic...
Survivors of moderate-severe Traumatic Brain Injury (TBI) are at risk for long-term cognitive, emotional, and behavioural problems. This prospective cohort study investigated self-reported executive, problems in the late chronic phase moderate severe TBI, if demographic characteristics (i.e., age, years education), injury (Glasgow Coma Scale score, MRI findings such as traumatic axonal (TAI), or duration posttraumatic amnesia), symptoms depression, neuropsychological variables first year...
The clinical benefit of early magnetic resonance imaging (MRI) in severe and moderate head injury is unclear. We sought to explore the prognostic value depth lesions depicted with MRI, also describe prevalence impact traumatic brainstem lesions. In a cohort 159 consecutive patients (age 5–65 years surviving acute phase) admitted regional level 1 trauma center, 106 (67%) were examined MRI within 4 weeks post-injury. Depth was categorized as: hemisphere level, central (BSI). outcome measure...
Objective: To assess cognitive function at 12 months after moderate and severe traumatic brain injury (TBI) separately, as well improvement from 3 to relationship global outcome.Methods: Cognitive among patients with (n = 30, Glasgow Coma Scale score (GCS) 9–3) 20, GCS ≤ 8), recruited an unselected neurosurgical cohort, all MRI performed in the early phase were assessed a neuropsychological test battery Outcome Extended. Healthy volunteers 47) matched for age, gender years of education...
The influence of alcohol is assumed to reduce consciousness in patients with traumatic brain injury (TBI), but research findings are divergent. aim this investigation was study the effects different levels blood concentration (BAC) on Glasgow Coma Scale (GCS) scores moderate and severe TBI relate severity based admission CT scan.In cohort study, 265 (age range 16-70 years) who were admitted St. Olavs University Hospital during a 7-year period prospectively registered. Of these, 217 (82%) had...
This study examines how injury mechanisms and early neuroimaging clinical measures impact white matter (WM) fractional anisotropy (FA), mean diffusivity (MD), tract volumes in the chronic phase of traumatic brain (TBI) WM integrity is associated with different outcome obtained at same time. Diffusion tensor imaging (DTI) 3 T was acquired more than 1 year after TBI 49 moderate‐to‐severe‐TBI survivors 50 matched controls. DTI data were analyzed tract‐based spatial statistics automated...
Mild traumatic brain injury (MTBI) is a frequent medical condition, and some patients report long-lasting problems after MTBI. In order to prevent MTBI, knowledge of the epidemiology important potential bias in studies should be explored. Aims this study were describe epidemiological characteristics MTBI Norwegian area evaluate representativeness successfully enrolled Trondheim follow-up study. During 81 weeks 2014 2015, all persons aged 16–60 years, presenting with possible emergency...
Patients with moderate traumatic brain injury (TBI) often are studied together patients severe TBI, even though the expected outcome of former is better. Therefore, we aimed to describe patient characteristics and 12-month outcomes, develop a prognostic model based on admission data, specifically for TBI. Glasgow Coma Scale scores 9–13 age ≥16 years were prospectively enrolled in 2 level I trauma centers Europe. Outcome Extended (GOSE) score was assessed at 12 months. A predicting disability...
Background There are no recent estimates of incidence rates mild traumatic brain injury (MTBI) from Norway. Moreover, reported rarely comprise cases MTBI evaluated in the primary care setting. In this study, we utilized existing data collected as part recruitment to a large, follow-up study patients with MTBI. We estimated rate MTBI, including who visited outpatient clinics, age group 16-59 years Norwegian region. Methods: During 81 weeks 2014 and 2015, all persons aged years, presenting...
Background and Purpose- We wanted to evaluate potential risk factors for unruptured intracranial aneurysms (UIAs) aneurysmal subarachnoid hemorrhage (aSAH) in a large, prospective study of the general population with collected before detection UIA or aSAH. Methods- All residents ≥20 years were invited HUNT (The Nord-Trøndelag Health Study). In this study, 89 951 participants included. The included standardized measurements blood pressure self-administered questionnaires. Cases aSAH from 1999...
ObjectiveTo investigate whether cognitive reserve moderates differences in functioning between patients with mild traumatic brain injury (MTBI) and controls without MTBI to examine postconcussion syndrome have lower than at 2 weeks 3 months after injury.DesignTrondheim follow-up study is a longitudinal controlled cohort assessments injury.SettingRecruitment level 1 trauma center general practitioner-run, outpatient clinic.ParticipantsPatients (n=160) according the World Health Organization...
Objective: To investigate the longitudinal evolution of three blood biomarkers: neurofilament light (NFL), glial fibrillary acidic protein (GFAP) and tau, in out-patients hospitalized patients with mild traumatic brain injury (mTBI) compared to controls, along their associations—in patients—with clinical characteristics demographic variables, ability discriminate mTBI from controls. Methods: A observation study including 207 mTBI, 84 age sex-matched community controls (CCs) 52 trauma (TCs)....
The assumption that the lung is an effective filter for gas bubbles of importance certain occupations (e.g., divers, astronauts) as well in accomplishment several medical procedures. filtering capacity was tested pigs by use continuous air infusion into right ventricle and a transesophageal echocardiographic transducer detection left atrium. Twenty pigs, anesthetized with pentobarbital sodium mechanically ventilated, were divided groups received at rates 0.05 (group 1a, n = 7), 0.10 2, 6),...