A5081247200- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Anesthesia and Pain Management
- Respiratory Support and Mechanisms
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Hemodynamic Monitoring and Therapy
- Trauma and Emergency Care Studies
- Trauma Management and Diagnosis
- Airway Management and Intubation Techniques
- COVID-19 and healthcare impacts
- Thermal Regulation in Medicine
- Sports injuries and prevention
- Intraoperative Neuromonitoring and Anesthetic Effects
- Optical Imaging and Spectroscopy Techniques
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
Trinity College Dublin
2023-2025
The University of Texas Southwestern Medical Center
2015-2024
Neurological Surgery
2010-2024
Southwestern Medical Center
2017-2024
Duke Medical Center
2006-2021
E Ink (South Korea)
2021
Yale University
2020
St Olav's University Hospital
2012-2019
Trondheim Kommune
2019
Brigham and Women's Hospital
2018
Postoperative delirium is a geriatric syndrome that manifests as changes in cognition, attention, and levels of consciousness after surgery. It occurs up to 50% patients major surgery associated with adverse outcomes, including increased hospital length stay, higher cost care, rates institutionalization discharge, readmission. Furthermore, it functional decline cognitive impairments As the age medical complexity our surgical population increases, practitioners need skills identify prevent...
Study Design. A single-blinded, randomized treatment study with a follow-up period of 6 months. Objective. To the long-term consequences whiplash neck sprain injuries in patients treated two different regimes during first 14 days after car accident. Patients group were encouraged to act as usual, i.e., continue engage their normal, pre-injury activities; that was compared another who given time off from work and immobilized using soft collar. The end point comparison evaluation subjective...
Background Postoperative cognitive dysfunction (POCD) is a significant cause of morbidity after noncardiac surgery. Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers brain injury inflammation. Methods Three hundred ninety-four patients older than 55 yr undergoing major elective surgery were enrolled in this prospective observational study. Apolipoprotein E...
Postoperative delirium is associated with increased morbidity and mortality. Preexisting cognitive impairment depression have been frequently cited as important risk factors for this complication. This prospective cohort study was designed to determine whether individuals who perform poorly on preoperative tests and/or exhibited depressive symptoms would be at high the development of postoperative delirium.One hundred nondemented patients, aged 50 yr older, scheduled undergo major, elective...
The management of elderly patients can be challenging for anesthesiologists many reasons, including altered pharmacokinetics and dynamics. This study compared the efficacy, safety, sugammadex moderate rocuronium-induced neuromuscular blockade reversal in adult (aged 18-64 yr) versus 65 yr or older) patients.This phase 3a, multicenter, parallel-group, comparative, open-label enrolled 162 aged 18 older, American Society Anesthesiologists class 1-3, scheduled surgery with general anesthesia...
Background and Purpose: Intra-arterial reperfusion therapies are expanding frontiers in acute ischemic stroke (AIS) management but there is considerable variability clinical practice. The use of general anesthesia (GA) one example. We aimed to better understand sedation practices AIS. Methods: An online survey was distributed the 68 active members Society Vascular Interventional Neurology (SVIN). Survey development based on discussions at SVIN Endovascular Stroke Round Table Meeting...
Background and Purpose— Neurocognitive decline occurs frequently after cardiac surgery persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation cellular energy metabolism, blockade the N-methyl-D-aspartate receptor, diminution inflammatory response, inhibition platelet activation. We therefore hypothesized that intraoperative magnesium administration would decrease postoperative cognitive impairment. Methods— After approval Duke University...
Total knee arthroplasty improves quality of life but is associated with postoperative cognitive dysfunction in older adults. This prospective longitudinal pilot study a parallel control group tested the hypotheses that (1) nondemented adults would exhibit primary memory and executive difficulties after total arthroplasty, (2) reduced preoperative hippocampus/entorhinal volume predict change, whereas leukoaraiosis lacunae volumes dysfunction.Surgery (n = 40) age-education-matched controls...
Abstract The cholinergic system is essential for memory. While degradation of pathways characterizes memory-related disorders such as Alzheimer’s disease, the neurophysiological mechanisms linking to human memory remain unknown. Here, combining intracranial brain recordings with pharmacological manipulation, we describe effects a blocker, scopolamine, on hippocampal formation during episodic We found that impairment caused by scopolamine was coupled disruptions both amplitude and phase...
BRIEF SUMMARY: We describe the use of adenosine-induced cardiac arrest to facilitate intracranial aneurysm clip ligation.Cerebral aneurysms are highly variable which may result in difficult surgical exposure for ligation select cases. Secure placement is often not feasible without temporarily decompressing aneurysm. This can be accomplished with temporary proximal vessels, or deep hypothermic circulatory on cardiopulmonary bypass, although these methods have their own inherent risks. Here we...
BackgroundIntracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined other neurological emergencies. Further, potential effect age on after ICH has not explored. This study was designed to test the hypothesis that interact modify ICH. MethodsAdult patients admitted with spontaneous primary supratentorial from July 2007 through April 2010 were assessed via...
Mild traumatic brain injury (MTBI) is a frequent medical condition, and some patients report long-lasting problems after MTBI. In order to prevent MTBI, knowledge of the epidemiology important potential bias in studies should be explored. Aims this study were describe epidemiological characteristics MTBI Norwegian area evaluate representativeness successfully enrolled Trondheim follow-up study. During 81 weeks 2014 2015, all persons aged 16–60 years, presenting with possible emergency...
Background: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) amyloid-β (Aβ). Objective: We asked whether tau/Aβ ratio (the pr imary outcome), individual AD biomarkers. also examined genetic/intraoperative factors influenced perioperative changes in Methods: Patients undergoing neurosurgical/otolaryngology procedures requiring lumbar cerebrospinal fluid (CSF) drain placement were...
Background There are no recent estimates of incidence rates mild traumatic brain injury (MTBI) from Norway. Moreover, reported rarely comprise cases MTBI evaluated in the primary care setting. In this study, we utilized existing data collected as part recruitment to a large, follow-up study patients with MTBI. We estimated rate MTBI, including who visited outpatient clinics, age group 16-59 years Norwegian region. Methods: During 81 weeks 2014 and 2015, all persons aged years, presenting...
Transient adenosine-induced asystole is a reliable method for producing short period of relative hypotension during surgical and endovascular procedures. Although the technique has been described in treatment brain arteriovenous malformations, aortic aneurysms, posterior circulation cerebral little description its use anterior aneurysms available.To assess benefits transient complex to describe our experience selected cases, provide first adenosine aneurysms.The cardiac arrest protocol...