A5040915656- Atherosclerosis and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Chemokine receptors and signaling
- Cardiac Fibrosis and Remodeling
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Pneumonia and Respiratory Infections
- Acute Myocardial Infarction Research
- Signaling Pathways in Disease
- Lipoproteins and Cardiovascular Health
- Respiratory Support and Mechanisms
- Viral Infections and Immunology Research
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Inflammatory Bowel Disease
- Emergency and Acute Care Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Complement system in diseases
- Machine Learning in Healthcare
St Olav's University Hospital
2016-2025
Norwegian University of Science and Technology
2016-2025
Oslo University Hospital
2005-2024
University of Oslo
2001-2024
UiT The Arctic University of Norway
2024
Christian Medical College
2024
Levanger Hospital
2024
Central Norway Regional Health Authority
2024
Centre for Inflammation Research
2016-2023
Helse Møre og Romsdal HF
2021
Although the participation of inflammation in atherogenesis is widely recognized, identification different components has not been clarified. In particular, role plaque destabilization fully understood.Our main findings were as follows: (1) a microarray experiment, we identified visfatin, one most recently adipokines, gene that was markedly enhanced carotid plaques from symptomatic compared with asymptomatic individuals. This finding confirmed when 7 patients and 14 lesions examined...
Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia–reperfusion. therefore a potential therapeutic target infarction (MI). We hypothesized that the IL-6 receptor antagonist tocilizumab would attenuate inflammation, secondarily reduce troponin T (TnT) release non-ST-elevation MI (NSTEMI). In two-centre, double-blind, placebo-controlled trial, 117 patients with NSTEMI were randomized at median of 2 days after symptom...
Abstract Inflammation is associated with development of atherosclerosis, and cholesterol crystals (CC) have long been recognized as a hallmark atherosclerotic lesions. CC appear early in the atheroma trigger inflammation by NLRP3 inflammasome activation. In this study we hypothesized whether employ complement system to activate inflammasome/caspase-1, leading release mature IL-1β, activation regulates CC-induced cytokine production. describe that activated both classical alternative...
We aimed to evaluate the clinical usefulness of qSOFA as a risk stratification tool for patients admitted with infection compared traditional SIRS criteria or our triage system; Rapid Emergency Triage and Treatment System (RETTS). The study was an observational cohort performed at one Department (ED) in urban university teaching hospital Norway, approximately 20,000 visits per year. All >16 years presenting symptoms signs suggesting (n = 1535) were prospectively included from January 1...
Abstract Background Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility infections. Previous observational studies randomized controlled trials micronutrients infections are limited. We performed Mendelian randomization (MR) analyses evaluate effect blood levels eight (copper, iron, selenium, zinc, beta-carotene, vitamin B12, C, D) on risk three (gastrointestinal infections, pneumonia, urinary tract...
Based on its role in inflammation and matrix degradation, we hypothesized a for osteoprotegerin (OPG), RANK, RANK ligand (RANKL) coronary artery disease.We examined the expression of various members OPG/RANKL/RANK axis patients with stable unstable angina atherosclerotic lesions apolipoprotein E-deficient (apoE(-/-)) mice. Our findings were: (1) Serum levels OPG were raised (n=40), but not those comparing controls (n=20); (2) mRNA RANKL increased T-cells accompanied by monocytes; (3) strong...
This study assessed the relationship between inflammatory mediators and indices of infarct size left-ventricular (LV) remodelling following successful primary percutaneous coronary intervention (PCI) in patients with first time ST elevation myocardial infarction (MI).Forty-two admitted an occluded single vessel were recruited consecutively. Cardiac magnetic resonance was used for serial assessment (2 days, 1 week, 2 months) size, microvascular obstruction (MO), LV remodelling. Inflammatory...
Abstract Background and Aim Accurate, noninvasive biomarkers are needed to diagnose monitor inflammatory bowel disease (IBD). Neutrophil gelatinase‐associated lipocalin (NGAL), also known as 2, is expressed in inflamed colonic epithelium neutrophilic granulocytes. This study explores its properties a biomarker feces plasma and, for the first time, compares fecal NGAL systematically with existing calprotectin. Methods was measured from 73 patients IBD, 21 infectious enterocolitis, irritable...
Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and successive morbidity. In mild TBI (mTBI), however, the extent persistence of innate are unknown. We determined plasma cytokine level changes over 12 months after an mTBI hospitalized non-hospitalized patients compared with community controls; examined their associations to injury-related demographic variables at admission. Prospectively, 207 presenting emergency department (ED) or general practitioner...
During HIV infection, cell-to-cell transmission results in endosomal uptake of the virus by target CD4+ T cells and potential exposure viral ssRNA genome to Toll-like receptors (TLRs). TLRs are instrumental activating inflammatory responses innate immune cells, but their function adaptive is less well understood. Here we show that synthetic ligands TLR8 boosted cell receptor signaling, resulting increased cytokine production upregulation surface activation markers. Adjuvant stimulation, not...
Although modulation of inflammatory processes has been suggested as a new treatment modality in heart failure (HF), our knowledge about abnormalities the cytokine network during HF is still limited. On basis previous cDNA array study examining peripheral blood mononuclear cells from patients, we hypothesized role for activin A, member transforming growth factor (TGF)-beta superfamily, pathogenesis HF.This had 4 main and novel findings. First, serum levels A were significantly elevated...
Inflammation is important in atherogenesis. Interleukin (IL)-1 the prototypic inflammatory cytokine. We hypothesized a dysbalance between and anti-inflammatory mediators IL-1 family coronary artery disease (CAD) possible modulation of these by HMG-CoA inhibitors (statins).In microarray screening experiment examining peripheral blood mononuclear cells (PBMCs) from 6 CAD patients 4 healthy control subjects, IL-1beta was identified as 1 25 genes whose expression were upregulated downregulated...
Chemokines play a pathogenic role in atherogenesis and plaque destabilization by activating directing leukocytes into the atherosclerotic plaque. However, stromal cell-derived factor (SDF)-1 was recently found to have antiinflammatory effects, we hypothesized that this chemokine could beneficial coronary artery disease.Plasma levels of SDF-1alpha were significantly decreased patients with stable (n=30) unstable angina compared healthy control subjects (n=20), particularly those disease. By...
Based on their role in T-cell homing into nonlymphoid tissue, we examined the of homeostatic chemokines CCL19 and CCL21 common receptor CCR7 coronary artery disease (CAD).We performed studies patients with stable (n=40) unstable angina healthy controls (n=20), vitro T-cells macrophages, apolipoprotein-E-deficient (ApoE-/-) mice human atherosclerotic carotid plaques. We found increased levels within lesions ApoE-/- mice, plaques, plasma CAD patients. Whereas strong expression was seen from...