A5008274720- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Imaging and Diagnostics
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Intensive Care Unit Cognitive Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Traumatic Brain Injury Research
- Adipokines, Inflammation, and Metabolic Diseases
- Complement system in diseases
- Cardiac Structural Anomalies and Repair
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- Non-Invasive Vital Sign Monitoring
- Blood Coagulation and Thrombosis Mechanisms
Oslo University Hospital
2016-2025
University of Oslo
2012-2023
Institutt for Eksperimentell Medisinsk Forskning
2005-2015
Center for Clinical Research (United States)
2011
Cardiovascular Research Center
2001-2002
Svendborg Sygehus
1990
Guidelines recommend normocapnia for adults with coma who are resuscitated after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow and may improve neurologic outcomes.We randomly assigned had been arrest of presumed or unknown cause admitted to the intensive care unit (ICU) in a 1:1 ratio either 24 hours (target partial pressure arterial carbon dioxide [Paco2], 50 55 mm Hg) Paco2, 35 45 Hg). The primary outcome was favorable outcome, defined as score 5...
Background Reduction of infarct size by ischemic postconditioning (IPost) has been reported in smaller proof‐of‐concept clinical studies, but not confirmed other studies. The principle needs to be evaluated larger groups ST‐elevation myocardial infarction (STEMI) patients before being implemented practice. This study assessed the effect postcoditioning on with STEMI treated primary percutaneous coronary intervention (PCI). Methods and Results Patients first‐time STEMI, <6 hours from...
Objective: Comatose patients resuscitated after out-of-hospital cardiac arrest receive therapeutic hypothermia. Bradycardia is frequent during hypothermia, but its impact on outcome remains unclear. We explore a possible association between bradycardia hypothermia and neurologic in comatose survivors of arrest. Design: Retrospective cohort study, from January 2009 to 2011. Setting: University hospital medical ICUs. Patients: One hundred eleven consecutive treated with Interventions: Patients...
Background— We aimed to investigate coronary angiographic findings in unselected out-of-hospital cardiac arrest patients referred immediate angiography (ICA) irrespective of their first postresuscitation ECG and determine whether this is useful select with no need ICA. Methods Results— All resuscitated admitted after without a clear noncardiac cause underwent Patients were retrospectively grouped according the blinded for ICA results: (1) ST elevation or presumably new left bundle branch...
BackgroundDuring atherogenesis, cholesterol precipitates into crystals (CC) in the vessel wall, which trigger plaque inflammation by activating NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome. We investigated relationship between CC, complement NLRP3 patients with cardiovascular disease.MethodsWe analysed plasma, peripheral blood mononuclear cells (PBMC) carotid plaques from advanced atherosclerosis applying ELISAs, multiplex cytokine assay, qPCR, immunohistochemistry,...
We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation infarction (STEMI). However, the mechanisms for this effect are not clear.In exploratory sub-study of ASSAIL-MI trial, we examined leukocyte differential counts and their relation to peak troponin T (TnT) STEMI patients randomised (n = 101) or placebo 98). performed RNA-sequencing on whole blood 40) cells 20). B cell subpopulations were flow cytometry 69).(i) had higher neutrophil...
A high prevalence of impaired glucose tolerance and unknown type 2-diabetes in patients with coronary heart disease no previous diagnosis diabetes have been reported. The aims the present study were to investigate abnormal regulation (AGR) 3 months after an acute ST-elevation myocardial infarction (STEMI) without known glucometabolic disturbance, evaluate reliability a 75-g oral test (OGTT) performed very early STEMI predict presence AGR at months, other potential predictors measured...
Cytokines of the IL-6 family have been related to infarct size and prognosis in patients with myocardial infarction. The aims present study were elucidate possible associations between necrosis left ventricular impairment members transsignalling system including soluble (s) IL-6R glycoprotein 130 (sgp130) ST-elevation infarction (STEMI) treated primary PCI. In blood samples from 1028 STEMI patients, collected in-hosptial, we found significant correlations peak TnT CRP (p < 0.001, all) LV...
Levosimendan is known as a calcium sensitizer, although it also to inhibit PDE3. We aimed isolate each component and estimate their contribution the increased cardiac contractility induced by levosimendan.Contractile force was measured in electrically stimulated ventricular strips from explanted failing human hearts left normal male Wistar rats. PDE activity two-step assay on ventricle.Levosimendan exerted positive inotropic effect (PIE) reaching maximum at 10(-5) M hearts. In presence of...
Background Reports on soluble interleukin‐6 (IL‐6) receptor ( sIL ‐6R) and glycoprotein 130 (sgp130) in ST ‐elevation myocardial infarction STEMI ) are few include a small number of patients. The aim this study was to investigate the possible association between levels these biomarkers acute phase future cardiovascular events. Methods Results Circulating IL ‐6, sgp130, ‐6R, C‐reactive protein CRP were measured 989 patients during 2007–2011, events recorded follow‐up. primary endpoint...
Abstract Purpose The clinical benefit of up-titration metoprolol to a guideline-recommended target dose after myocardial infarction (MI) is unknown. Our aim was investigate whether variation in exposure determined by cytochrome p450 enzyme 2D6 (CYP2D6 ) influences the occurrence major adverse cardiovascular events (MACE) and death (CV death) among patients treated with MI. Method This Mendelian randomization study performed using individual-level data from 1554 an acute CYPD26 genotype...
Abstract Men develop larger infarct sizes than women after a myocardial infarction (MI), but the mechanism underlying this sex difference is unknown. Here, we demonstrated that blood neutrophil counts post-MI were higher in male female mice. Castration-induced testosterone deficiency reduced to level females and increased survival post-MI. These effects mimicked by Osterix-directed ablation of androgen receptor bone marrow (BM). Mechanistically, androgens downregulated leukocyte retention...
Myocardial G protein-coupled receptor kinase 2 (GRK2) has been shown to be involved in the pathophysiology of congestive heart failure (CHF). However, cellular distribution this isoform, as well other isoforms GRK-arrestin system, not studied myocardial tissue. Thus expression and different GRK arrestin were investigated a rat model CHF. Rats subjected ligation left coronary artery or sham operation euthanized 2, 7, 42 days after surgical procedure. GRK2, GRK5, beta-arrestin-1,...
Background . The relevance of neutrophil extracellular traps (NETs) in acute ST-elevation myocardial infarction (STEMI) is unclear. We explored the temporal profile circulating NET markers and their associations to injury function adverse clinical events STEMI patients. Methods Results In 259 patients, blood samples were drawn before after PCI, on day 1, 4 months. Double-stranded deoxyribonucleic acid (dsDNA) myeloperoxidase-DNA (MPO-DNA) measured serum by a nucleic stain ELISA. Cardiac...