Circulating microparticles (cMPs) are phospholipid-rich vesicles released from cells when activated or injured, and contribute to the formation of intracoronary thrombi. Tissue factor (TF, CD142) is main trigger fibrin TF-carrying cMPs considered one most procoagulant cMPs. Similar types atherosclerotic lesions may lead different AMI, although mechanisms behind unresolved. Therefore, we aimed investigate phenotype found in plasma ACS patients its relation AMI severity thrombotic burden.In a...

Background Neutrophil extracellular traps, comprising chromatin and granule proteins, have been implicated in atherothrombosis. Design methods We investigated whether the circulating neutrophil traps markers, double-stranded DNA myeloperoxidase-DNA were associated with clinical outcome hypercoagulability patients stable coronary artery disease. Patients angiographically verified disease ( n = 1001) included. Follow-up was 2 years, recording 106 endpoints (unstable angina, non-haemorrhagic...

The aim of the present study was to compare circulating levels selected prothrombotic markers in patients suffering acute myocardial infarction (AMI) with and without left ventricular (LV) thrombus.One hundred AMI treated PCI on LAD dual antiplatelet therapy were included. LV thrombus formation detected by echocardiography and/or MRI 15 patients. Fasting blood samples drawn 4-5 days (baseline), 6-7 days, 8-9 2-3 weeks 3 months after for determination haemostatic markers.We found higher...

Abstract Background Individuals with type 1 diabetes are at increased risk of accelerated atherosclerosis, causing coronary artery disease (CAD). The underlying mechanisms remain unclear, but new theories proposed damage gut mucosa leakage and translocation microbiota products into the circulation, leading to inflammatory responses atherosclerosis. We therefore aimed study associations between related biomarkers atherosclerosis in individuals long-term diabetes. Methods In this...

Cardiovascular disease with disturbances in the haemostatic system, might lead to thrombotic complications clinical manifestations like acute myocardial infarction (AMI) and stroke. Activation of coagulation cascade subsequent increased thrombin generation, characterizes a prothrombotic phenotype. In present study we investigated whether markers were associated risk factors subgroups cohort patients angiographically verified coronary artery (CAD). The randomized long-term treatment...

Circulating microvesicles, released from activated/apoptotic cells, are involved in vascular complications and may be looked upon as biomarkers. Albuminuria is characteristic of disease progression type 2 diabetes mellitus. We aimed to investigate quantitative qualitative differences circulating microvesicles mellitus with without albuminuria whether 12-month exercise training influenced expression microvesicles.Coronary artery patients (n = 75), which 25 had albuminuria, were included....

Circulating microvesicles (cMV) are small phospholipid-rich blebs shed from the membrane of activated vascular cells that contribute to disease progression. We aimed investigate whether quality Nordic diet is associated with degree blood and cell activation measured by MV shedding in elderly patients after an acute myocardial infarction (AMI). One-hundred seventy-four aged 70–82 years were included this cross-sectional study. Fasting samples taken within 2 8 weeks AMI. Annexin V (AV)+ cMV...

Background & aimsCirculating microvesicles (cMV) are both effectors and biomarkers of cardiovascular disease (CVD), the effects omega 3 polyunsaturated fatty acids (n3 PUFA) in MV shedding not yet well known. Therefore, we aimed to investigate long-term n3 PUFA supplementation on cMV release from cells vascular compartment elderly subjects at very high risk CVD.MethodsWe included 156 patients 2–8 weeks after suffering an acute myocardial infarction OMEMI cohort. Subjects were randomly...

We investigated the effects of 12-month exercise training on hypercoagulability in patients with combined type 2 diabetes mellitus and coronary artery disease. Associations severity disease were further explored. Patients ( n = 131) randomized to or a control group. Blood was collected at inclusion after 12 months. Tissue factor, free total tissue factor pathway inhibitor, prothrombin fragment 1 + (F1 2) D-dimer determined by enzyme-linked immunosorbent assay ex vivo thrombin generation...

In patients with stable coronary heart disease (n = 1,001) we investigated the influence of tissue factor (TF) and TF pathway inhibitor (TFPI) polymorphisms on thrombin generation in vivo<i>, </i>measured by prothrombin fragment (F) 1 2, potential to generate ex vivo, measured calibrated automated thrombogram assay. Additionally, circulating levels TFPI were correlated different parameters generation. The 5466 –399 associated higher vivo<i>,</i> latter also a...

Epicardial and pericardial adipose tissue (EAT PAT) associate with atherosclerosis, however, discussed to have different inflammatory properties. We examined the NLRP3 inflammasome related pathway, playing a pivotal role in EAT, PAT subcutaneous AT (SAT), their relationship cell types anthropometric measures patients undergoing coronary artery bypass grafting.Biopsies from SAT were collected 52 heart disease (CHD) (median body weight 85.0 kg) 22 controls. RNA was extracted expression of...

We examined whether resting levels and exercise-induced changes during exercise ECG stress test (EST) of cardiac Troponin T (cTnT), NT-proBNP prothrombotic markers were affected by revascularization in patients with coronary artery disease (CAD).EST1 was performed before angiography revascularization, (n = 20) confirmed CAD, another EST (EST2) 9 weeks later. Blood samples drawn at rest within five min after termination ESTs.cTnT increased both ESTs (p < 0.001, all). Resting cTnT EST2 versus...

Arterial vasodilation is dependent on nitric oxide synthesized from L-arginine by endothelial synthase. Triathletes are reported to display altered serum concentrations of metabolites such as L-arginine, asymmetric dimethyl arginine (ADMA) and symmetric (SDMA) shortly after completing long-distance triathlon races. In other populations, similar changes established risk markers cardiovascular disease. The objective this study was assess for synthesis in triathletes one week following a race....

Abstract Background The gut microbiota produces numerous metabolites that can enter the circulation and exert their effects outside gut. Some have been implicated in pathogenesis of chronic heart failure (HF). Several studies reported altered composition circulating patients with HF compared to healthy controls (HC). However, limited data is available on potential interplay between dysbiotic features metabolome these patients. Purpose To examine differences HC, association cardiac function...

Abstract Delirium is a neuropsychiatric syndrome commonly presenting during acute illness. The pathophysiology of delirium unknown, but neuroinflammation suggested to play role. In this cross-sectional study, we aimed investigate whether cell-free DNA and markers neutrophil extracellular traps in serum CSF were associated with neuronal damage, assessed by neurofilament light chain. Hip fracture patients (n = 491) median (25, 75 percentiles) age 83 (74, 88) years 69% females enrolled at Oslo...

&lt;i&gt;Objectives:&lt;/i&gt; It was our aim to study the levels of &lt;i&gt;L&lt;/i&gt;-arginine, substrate for nitric oxide and asymmetric dimethylarginine (ADMA), an endogenous inhibitor synthase, their relation maintenance sinus rhythm after electrical cardioversion atrial fibrillation (AF), as well effects angiotensin receptor blockade on these variables. &lt;i&gt;Methods:&lt;/i&gt; In a double-blind, placebo-controlled study, patients with persistent AF were randomised receive...

Type 1 diabetes is associated with atherothrombosis, but limited data exist on procoagulant activity in the young. We investigated children/adolescents type using intensified insulin treatment compared controls a 5-year follow-up study, and further any associations cardiovascular risk factors.The study included 314 120 healthy controls. Prothrombin fragment 1+2 (F1+2), D-dimer, tissue-factor-procoagulant-activity (TF-PCA), tissue-factor-pathway-inhibitor (TFPI) were analyzed ELISAs.F1+2,...

Background . Type 1 diabetes is a chronic disease including hyperglycemia and accelerated atherosclerosis, with high risk of micro- macrovascular complications. Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis discussed to be markers vascular dysfunction hypercoagulability. Limited knowledge exists on hypercoagulability in young diabetics. We aimed investigate cMVs over five-year period children/adolescents type compared controls any...

Background. Inflammation is central in development of cardiovascular disease (CVD). Aberrant function the Nod-Like Receptor Protein 3 (NLRP3) inflammasome, a mediator proinflammatory response, has been associated with atherosclerosis. The influence genetic determinants on this inflammatory pathway and its downstream effects less known. We aimed to investigate frequency single NLRP3 gene variant according clinical outcome CVD NLRP3-related markers. Methods. In observational study, we included...