A5057514868- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Atherosclerosis and Cardiovascular Diseases
- Nutrition and Health in Aging
- Exercise and Physiological Responses
- Inflammasome and immune disorders
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Diet and metabolism studies
- Gut microbiota and health
- Extracellular vesicles in disease
- Cardiovascular Effects of Exercise
- Receptor Mechanisms and Signaling
- Signaling Pathways in Disease
- Cerebrovascular and Carotid Artery Diseases
- Galectins and Cancer Biology
- Cardiovascular Function and Risk Factors
- Behavioral Health and Interventions
- Antiplatelet Therapy and Cardiovascular Diseases
- Chemokine receptors and signaling
Vestre Viken Hospital Trust
2024-2025
Bærum Sykehus
2024
Oslo University Hospital
2011-2022
University of Oslo
2015-2019
Center for Clinical Research (United States)
2011
Carotid intima-media thickness (cIMT) holds prognostic information for future cardiovascular disease and is associated with the extent of coronary atherosclerosis. We investigated effect exercise on cIMT progression in patients both type 2 diabetes artery (CAD). Patients CAD (n = 137) were randomized to training or standard follow-up. The 12 month program contained 150 min weekly combined aerobic resistance training. High-resolution ultrasonography distal part common carotid (CCA) was...
Objective: Few exercise trials have focused on patients with both type 2 diabetes and coronary artery disease. We investigated the effects of 1 year training HbA 1c VO 2peak in these patients. Methods: Patients disease ( n = 137) were randomised to combined or control group. was measured at beginning end study. Changes , also ventilatory threshold time exhaustion, assessed by cardiopulmonary testing. Results: No differences changes between groups observed whereas exhaustion increased...
Introduction Atrial fibrillation is the most prevalent sustained arrhythmia worldwide and expected to increase substantially within coming years. Although lifestyle changes risk factor modification are now acknowledged as central components of atrial management, effects exercise on disease-specific outcomes still not extensively documented due few high-quality randomised trials. The primary objective Norwegian Exercise in Fibrillation Trial (NEXAF) assess over 12 months key clinical...
Background. Chronic heart failure (CHF) is associated with increased inflammation, and exercise training has in some studies been shown to have anti-inflammatory effect, although controversies exist. We investigated the effects of CHF patients on markers further explored any association between inflammation severity etiology disease. Methods. Eighty stable were randomized 4 months group-based high intensity or a control group. Physical capacity was measured by 6-minute walk test cycle...
This study tested a physical activity intervention and the self‐determination theory ( SDT ) process model of health‐behavior change health among 108 adult patients with both diabetes mellitus type 2 DM 2) coronary artery disease CAD ). Patients were randomly assigned to an organized group (led by instructors) or non‐physical control group. At baseline after 12 months, we measured following: needs satisfaction, autonomous controlled motivation for activity, perceived competence blood sugar...
Background: Adipose tissue produces pro-inflammatory mediators involved in the atherosclerotic process. We investigated whether 12-month exercise training patients with type 2 diabetes mellitus and coronary artery disease would reduce circulating levels genetic expression of interleukin-18, Caspase-1 NLR pyrin domain containing 3 pathways. Correlations to glucometabolic variables; fasting glucose, HbA1c, duration diabetes, insulin, C-peptide, insulin resistance (measured by homeostatic model...
Adipokines are highly active biopeptides involved in glucose metabolism, insulin regulation and the development progression of obesity its associated diseases. It includes, among others, adiponectin, visfatin tumor necrosis factor alpha (TNFα). The sources adipokines their associations with glucometabolic variables not completely understood.In this cross-sectional study, we aimed to investigate whether gene expression levels subcutaneous adipose tissue (SAT) selected corresponding...
Previous studies on type 2 diabetes have shown an association between exercise capacity and insulin resistance. In patients with coronary artery disease (CAD) is often reduced due to exercise-induced ischemia. We investigated the glucometabolic control, including homeostatic model assessment (HOMA) of resistance, in CAD without ischemia.In 137 (age 63.1 ± 7.9) cardiopulmonary testing treadmill was performed using a modified Balke protocol. The highest oxygen uptake (VO2peak) reported as 30-s...
Abstract Aims Short-term treatment with calcium channel blockers lowers levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) and reduces rhythm-related symptoms compared to beta-blockers. The aim this study was compare the effects metoprolol diltiazem for rate control in patients permanent atrial fibrillation (AF) after 6 months. Methods results Men women AF preserved left ventricular systolic function were randomized receive either 360 mg or 100 once daily. primary endpoint level...
Objective: We have previously reported insignificant changes in HbA 1c after exercise patients with both type 2 diabetes and coronary artery disease. In this study, we investigated the effect of on endothelial function possible associations between . Methods: Patients disease ( n = 137) were randomised to 12 months or standard follow-up. Endothelial was assessed by circulating biomarkers (E-selectin, intercellular adhesion molecule-1, vascular cell von Willebrand factor, tissue plasminogen...
Circulating microvesicles, released from activated/apoptotic cells, are involved in vascular complications and may be looked upon as biomarkers. Albuminuria is characteristic of disease progression type 2 diabetes mellitus. We aimed to investigate quantitative qualitative differences circulating microvesicles mellitus with without albuminuria whether 12-month exercise training influenced expression microvesicles.Coronary artery patients (n = 75), which 25 had albuminuria, were included....
Purpose: Adipose tissue inflammation plays a role in atherosclerosis and type 2 diabetes (T2DM). We aimed to investigate whether 12 months of exercise training patients with both T2DM coronary artery disease (CAD) reduced the genetic expression proinflammatory markers fractalkine (CX3CL1) its receptor (CX3CR1) monocyte chemoattractant protein-1 (MCP-1) subcutaneous adipose tissue. Expression genes circulating leukocytes levels were also investigated. Patients methods: A total 137 CAD...
Introduction: Adipokines, expressed by adipose tissue (AT), have been associated with metabolic disturbances and coronary artery disease (CAD). The impact of exercise training on the AT in patients suffering from both diabetes CAD is unknown. To gain knowledge changes ATs' inflammatory profile such a population, we investigated effects long-term selected adipokines their associations physical performance glucometabolic variables. Adiponectin was based its anti-atherogenic anti-diabetic...
We investigated the effects of 12-month exercise training on hypercoagulability in patients with combined type 2 diabetes mellitus and coronary artery disease. Associations severity disease were further explored. Patients ( n = 131) randomized to or a control group. Blood was collected at inclusion after 12 months. Tissue factor, free total tissue factor pathway inhibitor, prothrombin fragment 1 + (F1 2) D-dimer determined by enzyme-linked immunosorbent assay ex vivo thrombin generation...
Investigate effects of long-term exercise on the remodeling markers MMP-9, TIMP-1, EMMPRIN and Galectin-3 in combined type 2 diabetes mellitus (T2DM) coronary artery disease (CAD) patients. Any associations between these biomarkers glucometabolic variables were further assessed at baseline.137 patients (age 41-81 years, 17.2% females) included randomized to a 12-months program or control group. Fasting blood samples subcutaneous adipose tissue (AT) taken inclusion after 12-months. The...
Abstract Aim Gut leakage has been shown to associate with low-grade inflammation and lower cardiorespiratory fitness in diabetic subjects. We aimed investigate whether gut markers related patients both coronary artery disease type 2 diabetes, these were affected by long-term exercise training. Methods Patients angiographically verified diabetes mellitus (n = 137) randomized either 12 months intervention or conventional follow-up. A cardiopulmonary test fasting blood samples obtained before...
Background . Promising results regarding potential anti-inflammatory and antiatherosclerotic effects of gliptins have been reported. Our aim was to investigate whether saxagliptin treatment modifies expression inflammatory markers, primarily in peripheral blood mononuclear cells (PBMCs) circulating leukocytes patients with stable coronary artery disease (CAD) T2DM. Methods Patients (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Background Exercise is considered beneficial for managing comorbidities in atrial fibrillation (AF) patients the long term, and emerging evidence also indicate that high-intensity interval training (HIIT) may reduce AF burden symptoms. However, more data on impact of individual sessions recurrence needed to understand mechanisms tailor exercise recommendations. Purpose To assess temporal relationship between recurrent episodes among previously inactive with paroxysmal or persistent...