A5038791632- Fatty Acid Research and Health
- Cardiovascular Disease and Adiposity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pharmaceutical Practices and Patient Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Pharmaceutical studies and practices
- Hemophilia Treatment and Research
- Blood properties and coagulation
- Vitamin K Research Studies
- Pharmacovigilance and Adverse Drug Reactions
- Dementia and Cognitive Impairment Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Drug-Induced Adverse Reactions
- Venous Thromboembolism Diagnosis and Management
- Eicosanoids and Hypertension Pharmacology
- Stroke Rehabilitation and Recovery
- Digestive system and related health
- Poisoning and overdose treatments
- Pharmacological Effects and Toxicity Studies
- Ginseng Biological Effects and Applications
- Galectins and Cancer Biology
- Intramuscular injections and effects
- Atrial Fibrillation Management and Outcomes
- Inflammatory Bowel Disease
- Cholinesterase and Neurodegenerative Diseases
Oslo University Hospital
2015-2024
University of Oslo
1974-2023
Institutt for Eksperimentell Medisinsk Forskning
2015
Akershus University Hospital
2003
Norwegian Medical Association
1999
Ullevål Sykehusapotek
1990-1997
University Hospital Ulm
1991-1996
Norwegian Medicines Agency
1984
Norwegian Defence Research Establishment
1972
Background: High intake of marine n-3 polyunsaturated fatty acids (PUFA) has been associated with reduced risk cardiovascular events; however, this not confirmed in patients a recent acute myocardial infarction (AMI). Elderly are at particularly increased after infarction, but few trials address group specifically. Omega-3 hold the potential to reduce events limited adverse effects vulnerable group. The hypothesis was that daily addition 1.8g PUFA standard care secondary prophylaxis elderly...
To evaluate whether depression in Parkinson disease (PD) is more closely related to the underlying neuropathological process or environmental and psychological factors by correlating PD with various clinical demographic variables.Major depression, level of depressive symptoms as measured Montgomery-Aasberg Depression Rating Scale (MADRS), characteristics were investigated a community-based cross-sectional study carefully diagnosed patients PD. Both bivariate multivariate correlation analyses...
Objective Pouchitis is a common and troublesome condition in patients operated on with ileal-pouch-anal-anastomosis (IPAA). A disturbed microecology the pouch has been suggested as one possible explanation. In previous double-blind, randomized, controlled study we demonstrated clinical improvement of symptoms ulcerative colitis (UC) IPAA, during intervention live probiotic microbes Lactobacilli Bifidobacteriae. The aim present was to confirm our results much larger material, including...
Circulating microparticles (cMPs) are phospholipid-rich vesicles released from cells when activated or injured, and contribute to the formation of intracoronary thrombi. Tissue factor (TF, CD142) is main trigger fibrin TF-carrying cMPs considered one most procoagulant cMPs. Similar types atherosclerotic lesions may lead different AMI, although mechanisms behind unresolved. Therefore, we aimed investigate phenotype found in plasma ACS patients its relation AMI severity thrombotic burden.In a...
The cardiovascular benefit from n-3 polyunsaturated fatty acids (PUFAs) after acute myocardial infarction (AMI) is controversial, and the importance of serum eicosapentaenoic acid (EPA) docosahexaenoic (DHA) concentrations for clinical events unclear.To assess changes in EPA DHA during PUFA supplementation their association with incident events.In OMEMI trial, elderly patients a recent AMI were randomized to 1.8 g/day EPA/DHA or control (corn oil) 2 years. primary outcome was composite AMI,...
Pouchitis is a common and troublesome condition, disturbed microbiological flora mucosal blood flow in the pouch have been suggested as possible causes. Laser Doppler flowmetry (LDF) has used successfully to measure gastric colonic perfusion humans. The aim of this study was evaluate effect intervention with probiotics on ileal inflammation pouch, assessed by endoscopy, histology, fecal calprotectin LDF.A fermented milk product (Cultura; 500 ml) containing live lactobacilli (La-5)...
The objective was to describe the psychosocial burden experienced by informal carers of elderly stroke victims, and identify its predictors among baseline characteristics patients. From a prospective study 171 patients admitted geriatric ward for rehabilitation in acute phase, 68 living at home with primary caregiver were identified 6 months after stroke. At baseline, all assessed respect motor function, cognitive global handicap activities daily living, caregivers assessed, using Relatives'...
The validity and reliability of the Barthel index were studied in 60 geriatric patients, 87 stroke 102 patients with hip fracture, using a factor analysis methodology which explicitly accounts for ordinal nature scoring on each item. findings substantiate that is unidimensional among but not or fracture. In latter two groups, one related to mobility, other bodily functions. A sum-score characterize fracture does take into account complex structure index.
129 patients with thrombosis were treated heparin for 5 d and followed platelet counts coagulation examinations. Of 77 2 different brands of hog mucosa heparin, only 1 developed persistent thrombocytopenia below 100 X 10(9)/1. 52 beef lung patient thrombocytopenia. No intravascular or activated fibrinolysis during treatment.
Both epidemiological and randomized clinical studies suggest that supplementation with very-long-chain marine polyunsaturated n-3 fatty acids (n-3 PUFA) have cardioprotective effects, however these results are not without controversy. Study population, sample-size, type of endpoint all varied widely accross different studies.Therefore, the aims present study to evaluate effect 2 years capsules very-long chain PUFA on top standard therapy in elderly patients after acute myocardial infarction...
Recent randomized clinical trials have raised concerns regarding potential off target adverse effects from supplementation of n-3 polyunsaturated fatty acids (PUFA) on atrial fibrillation (AF) risk. We aimed to assess risk and mediators AF 'micro-AF' PUFA in post-myocardial infarction (MI) patients.In the OMEMI trial, 70-82 y. o. patients with a recent MI were 1.8 g/day eicosapentaenoic-/docosahexaenoic acid (EPA/DHA) or placebo (corn oil) for two years. New-onset was recorded by detection...
Objectives. Ageing is one of the strongest risk factors for atrial fibrillation (AF), and additional are also closely related to ageing. Remodeling part pathophysiology AF, a possible common denominator ageing other AF factors. The aim this study was investigate any association between presence biomarkers, leukocyte telomere length (LTL) sirtuin-1 (SIRT-1), cardiac remodeling biomarkers Galectin-3 sST2 in elderly myocardial infarction (MI) patients. Design. Patients were included after...
Background: Pouchitis is a common and troublesome condition in patients operated on with ileal-pouch-anal-anastomosis (IPAA). A disturbed mucosal perfusion the pouch has been suggested as possible cause. Laser Doppler flowmetry (LDF) used successfully to measure gastric colonic humans. In previous study, we demonstrated reduced distal part of pouch, during probiotic intervention, examined by LDF measurement. The aim present study was confirm our results much larger material, compare...
Abstract Background Telomeres are non-coding sequences at the end of eukaryote chromosomes, which in complex with associated proteins serve to protect subtelomeric DNA. shorten each cell division, regarded as a biomarker for aging and have also been suggested play role atherosclerosis cardiovascular disease (CVD). The aim present study was explore associations between leukocyte telomere length serum polyunsaturated fatty acids, diet, risk factors features myocardial infarction (MI) elderly...
Summary The activation of factor IX purified from human plasma has been studied. Factor XIa and kallikrein separately activated to IXa. In both cases a had an apparent molecular weight about 42–45000 in sodium dodecyl sul-phate-polyacrylamide disc gel electrophoresis compared with 70000 for the native IX. by required Ca2+-ions whereas did not influence kallikrein. A mixture tissue thromboplastin VII or RusselPs-viper venom alone activate Trypsin plasmin inactivated
Recent studies suggest gut-derived lipopolysaccharide (LPS)-translocation to play a role in both systemic inflammation and inflammatory adipose tissue. We aimed investigate whether circulating LPS-related markers corresponding genetic expression tissue were associated with obesity, cardiometabolic risk factors, dietary habits patients coronary artery disease.