A5066544520- Liver Diseases and Immunity
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Galectins and Cancer Biology
- Renal Transplantation Outcomes and Treatments
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Bowel Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Macrophage Migration Inhibitory Factor
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Inflammatory mediators and NSAID effects
- Microscopic Colitis
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
Oslo University Hospital
2015-2024
University of Oslo
2011-2024
Akershus University Hospital
2003-2020
Institutt for Eksperimentell Medisinsk Forskning
2020
United Nations Industrial Development Organization
2017
(2004). Normalization of faecal calprotectin: a predictor mucosal healing in patients with inflammatory bowel disease. Scandinavian Journal Gastroenterology: Vol. 39, No. 10, pp. 1017-1020.
<h3>Objective</h3> Although serrated polyps may be precursors of colorectal cancer (CRC), prospective data on the long-term CRC risk in individuals with are lacking. <h3>Design</h3> In a population-based randomised trial, 12 955 aged 50–64 years were screened flexible sigmoidoscopy, while 78 220 comprised control arm. We used Cox models to estimate HRs 95% CIs for among ≥1 large polyp (≥10 mm diameter), compared adenomas at screening, and population controls, multivariate logistic regression...
Inflammatory bowel disease (IBD) in patients with primary sclerosing cholangitis (PSC) seems to differ from IBD without PSC, but a systematic, prospective study of PSC has until now not been reported. We aimed describe the clinical, endoscopic, and histopathologic features PSC-IBD liver-transplanted nontransplanted patients.PSC (n = 184) were included underwent ileocolonoscopy assessment segmental histopathology.A total 155 (84%) had IBD, whom 39 (25%) undergone colectomy. The an intact...
Lifetime risk of biliary tract cancer (BTC) in primary sclerosing cholangitis (PSC) may exceed 20%, and BTC is currently the leading cause death patients with PSC. To open new avenues for management, we aimed to delineate clinically relevant genomic pathological features a large panel PSC-associated (PSC-BTC).We analyzed formalin-fixed, paraffin-embedded tumor tissue from 186 PSC-BTC 11 centers eight countries all anatomical locations included. We performed DNA sequencing at 42 genetic loci...
Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy frequently complicated by cholangiocarcinoma (CCA). Massive proliferation of biliary tree stem/progenitor cells (BTSCs), expansion peribiliary glands (PBGs), and dysplasia were observed in PSC. The aims the present study to evaluate involvement PBGs BTSCs CCA which emerged PSC patients. Specimens from normal liver (n = 5), 20), PSC‐associated 20) included. Samples processed for histology, immunohistochemistry,...
Several characteristic features of the fecal microbiota have been described in primary sclerosing cholangitis (PSC), whereas data on mucosal are less consistent. We aimed to use a large colonoscopy cohort investigate key knowledge gaps, including role gut PSC with inflammatory bowel disease (IBD), effect liver transplantation (LT), and whether recurrent (rPSC) may be used define consistent irrespective LT.We included 84 51 transplanted patients (PSC-LT) 40 healthy controls (HCs) performed...
Background: People with primary sclerosing cholangitis (PSC) have a 20% lifetime risk of biliary tract cancer (BTC). Using whole-exome sequencing, we characterized genomic alterations in tissue samples from BTC underlying PSC. Methods: We extracted DNA formalin-fixed, paraffin-embedded tumor and paired nontumor 52 resection or biopsy specimens patients PSC performed sequencing. Following copy number analysis, variant calling, filtering, putative PSC-BTC-associated genes were assessed by...
Pouchitis is a common and troublesome condition, disturbed microbiological flora mucosal blood flow in the pouch have been suggested as possible causes. Laser Doppler flowmetry (LDF) has used successfully to measure gastric colonic perfusion humans. The aim of this study was evaluate effect intervention with probiotics on ileal inflammation pouch, assessed by endoscopy, histology, fecal calprotectin LDF.A fermented milk product (Cultura; 500 ml) containing live lactobacilli (La-5)...
Objective. The aim of this study was to delineate the clinical outcomes and pathological characteristics surgically resected endocrine tumors pancreas determine importance World Health Organization (WHO) tumor-node metastasis (TNM) classifications, resection status, Ki-67 expression for long-term survival. Patients methods. Sixty-nine patients underwent surgical tumor with curative intent during 1990–2007. Hospital records were reviewed retrospectively medical, surgical, pathological,...
Until recently, pancreas transplantation has mostly been performed with exocrine drainage via duodenojejunostomy (DJ). Since 2012, DJ was substituted duodenoduodenostomy (DD) in our hospital, allowing endoscopic access for biopsies. This study assessed safety profiles DD versus procedures and clinical outcomes the technique transplantation. patients (n = 117; 62 simultaneous pancreas-kidney [SPKDD ] 55 alone [PTADD median follow-up 2.2 years) were compared 179; 167 SPKDJ 12 PTADJ )...
Patients with colorectal liver metastases (CLM) commonly receive neoadjuvant chemotherapy (NACT) prior to surgical resection. NACT may induce immunogenic cell death subsequent recruitment of T-cells the tumor microenvironment, which could be exploited by immune checkpoint inhibition (ICI). In theory, this expand use ICI obtain responses also in microsatellite stable cancer, but evidence suggest optimal treatment schedules are lacking. study, densities total-, cytotoxic-, helper- and...
Metastatic colorectal cancer (CRC) is associated with highly variable clinical outcome and response to therapy. The recently identified consensus molecular subtypes (CMS1-4) have prognostic therapeutic implications in primary CRC, but whether these are valid for metastatic disease unclear. We performed multi-level analyses of resectable CRC liver metastases (CLM) identify characteristics evaluate the relevance.In this ancillary study Oslo-CoMet trial, CLM tumor-adjacent tissue from 46...
The surgical technique with duodeno-duodenal enteroanastomosis of pancreas transplants allows for representative endoscopic ultrasound-guided needle biopsies the donor duodenum and graft. We assessed whether histological findings in transplanted duodenal can indicate rejection pancreas. Since September 2012, a has been default transplantations at our center. In 67 recipients we prospectively examined 113 procedures from grafts (97 per protocol 16 on indication). All graft were evaluated...
Several studies have described an increased cyclooxygenase-2 (COX-2) expression in pancreatic cancer, but the role of COX-2 tumour development and progression is not clear. The aim present study was to examine cancer cells stromal specimens, explore PGE2 stellate cell proliferation collagen synthesis.Immunohistochemistry immunofluorescence performed on slides from whole sections tissue blocks using antibodies against α-smooth muscle actin (αSMA). Pancreatic (PSC) were isolated surgically...
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations discussions focused the evaluation of long-term allograft health, including noninvasive tissue monitoring, immunosuppression optimization, structural changes. Potential revision rejection classification scheme to better accommodate communicate late T cell-mediated patterns related changes,...
Background: Pouchitis is a common and troublesome condition in patients operated on with ileal-pouch-anal-anastomosis (IPAA). A disturbed mucosal perfusion the pouch has been suggested as possible cause. Laser Doppler flowmetry (LDF) used successfully to measure gastric colonic humans. In previous study, we demonstrated reduced distal part of pouch, during probiotic intervention, examined by LDF measurement. The aim present study was confirm our results much larger material, compare...
Gastric hyperplastic polyps are the second most common subtype of gastric polyps. There has been an ongoing debate about their precise diagnostic criteria and etiological associations.A total 208 that were originally diagnosed as in our department during 8-year period reviewed using recently emphasized criteria, clinicopathologic associations explored.Only 41 cases confirmed polyps, whereas 103 (49%) reclassified polypoid foveolar hyperplasia, 64 (31%) mucosal prolapse distinguished by basal...
Primary sclerosing cholangitis (PSC) occurs in 2%-8% of patients who suffer from ulcerative colitis (UC). For require colectomy, ileal pouch-anal anastomosis (IPAA) or ileorectal (IRA) is employed to preserve continence.We evaluated the outcomes after IPAA and IRA for with UC-PSC, using UC but without PSC as controls (UC-only group). In a case-control study conducted at Sahlgrenska University Hospital, Sweden, UC-PSC (N=48; 31 17 IRA) were compared only (N=113; 62 51 IRA). Functional...
The underlying mechanism of liver regeneration after Associating Liver Partition and Portal vein ligation (PVL) for Staged hepatectomy (ALPPS) is still unclear. aim this study was to evaluate the relationship between future remnant (FLR) volume, characteristics restoration function in an experimental model ALPPS.An ALPPS rats developed with selective PVL, parenchymal transection partial (step 1), followed by resection 2). Three different groups FLR sizes 30, 20 10 per cent total volume were...
We previously demonstrated that people with primary sclerosing cholangitis (PSC) had reduced gut microbial capacity to produce active vitamin B6 (pyridoxal 5'-phosphate [PLP]), which corresponded lower circulating PLP levels and poor outcomes. Here, we define the extent biochemical clinical impact of deficiency in PSC from several centers before after liver transplantation (LT).We used targeted liquid chromatography-tandem mass spectrometry measure vitamers B6-related metabolic changes blood...