A5102854738- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Orthopaedic implants and arthroplasty
- Helicobacter pylori-related gastroenterology studies
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Cardiovascular Function and Risk Factors
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Gastric Cancer Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Cancer Treatment and Pharmacology
- Inflammatory Bowel Disease
- Gastroesophageal reflux and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Atrial Fibrillation Management and Outcomes
- Advanced MRI Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Inflammatory mediators and NSAID effects
- Proteoglycans and glycosaminoglycans research
- Cancer, Hypoxia, and Metabolism
Izumi City General Hospital
2020-2024
Nagoya City University
2012-2023
Kyoto City Hospital
2023
Kobe University
2020-2022
Weatherford College
2020-2022
Mizuho (Japan)
2021-2022
Gifu University
2005-2022
Nagoya University
2022
Creative Commons
2022
Japanese Red Cross Society Kyoto Daini Hospital
2010-2021
Abstract Renal denervation is a promising new non-pharmacological treatment for resistant hypertension. However, there lack of data from Asian patients. The REQUIRE trial investigated the blood pressure-lowering efficacy renal in treated patients with hypertension Japan and South Korea. Adults (seated office pressure ≥150/90 mmHg 24-hour ambulatory systolic ≥140 mmHg) suitable artery anatomy were randomized to ultrasound or sham procedure. primary endpoint was change baseline at 3 months. A...
Abstract Despite an initial response to androgen deprivation therapy, prostate cancer (PCa) progresses eventually from androgen-dependent androgen-independent phenotype. One of the mechanisms relapse is antiandrogen withdrawal phenomenon caused by mutation 877th amino acid receptor (AR). In present study, we established a method measure concentration androstenediol (adiol) in tissue. We found that adiol maintains high PCa tissue even after therapy. Furthermore, stronger activator mutant AR...
Background: Direct evidence for Rho-kinase activation in patients with pulmonary hypertension (PH) is still lacking. Methods and Results: activity circulating neutrophils was examined by determining the ratio of phosphorylated/total forms myosin-binding subunit, a substrate Rho-kinase, 40 consecutive PH healthy controls. Next, expression isolated human lung tissues (5 idiopathic arterial [IPAH], 5 controls) vascular reactivity small arteries vitro (4 IPAH, 4 controls). significantly...
To determine the proportion of dogs with thoracolumbar intervertebral disk herniation (IVDH) that successfully recovered following hemilaminectomy and fenestration, time to ambulation (TTA) in affected after surgery, frequency urinary fecal incontinence document long-term complications.Retrospective case series.831 IVDH treated by concomitant fenestration same surgeon.For all dogs, neurologic deficits before surgery had been assessed a modified grading system. Dogs were reexamined over...
Abstract Aims Mitral annular disjunction is fibrous separation between the attachment of posterior mitral leaflet and basal left ventricular myocardium initially described in dissected hearts. Currently, it commonly evaluated by echocardiography, potential relationships with valve prolapse arrhythmia have been suggested. However, controversy remains as its prevalence extent not fully elucidated normal living subjects. Methods results Systolic datasets cardiac computed tomography obtained...
Abstract We previously reported that the transplantation of neural stem/progenitor cells (NSPCs) can contribute to repair injured spinal cord in adult rats and monkeys. In some cases, however, most transplanted adhered cavity wall failed migrate integrate into host cord. this study we focused on chondroitin sulfate proteoglycan (CSPG), a known constituent glial scars is strongly expressed after injury (SCI), as putative inhibitor NSPC migration vivo . hypothesized digestion CSPG by...
Abstract BACKGROUND Cyclooxygenase (COX) ‐2, an inducible isoform of COX, has been observed to be expressed in prostate cancer. Several studies have reported that COX‐2 overexpression is associated with carcinogenesis, cell growth, angiogenesis, apoptosis, and invasiveness a variety tumor types. METHODS To investigate the function cancer directly, we stably transfected human full‐length cDNA into LNCaP cells (LNCaP‐COX‐2), which express low levels endogenous COX‐2. RESULTS The level mRNA...
The behavior of cells is generally considered to be regulated by environmental factors, but the molecules in milieu neural stem have been little studied. We found immunohistochemistry that chondroitin sulfate (CS) existed surroundings nestin-positive or stem/progenitor rat ventricular zone telencephalon at embryonic day 14. Brain-specific proteoglycans (CSPGs), including neurocan, phosphacan/receptor-type protein-tyrosine phosphatase beta, and neuroglycan C, were detected zone. Neurospheres...
To evaluate the in-vivo plaque composition and characteristics in patients with type 2 diabetes mellitus (DM) using Virtual Histology intravascular ultrasound (VH IVUS).In 90 stable angina pectoris, de novo target vessels were studied components analysed. Patients divided into two groups: a diabetic group (36 vessels) non-diabetic (54 vessels).The percentage area of necrotic core dense calcium significantly larger DM than non-DM (necrotic core: 11.0% (interquartile range (IQR): 7.2-15.2%) vs...
The management of hereditary diffuse-type gastric cancer revolves around surveillance biopsies and the timing prophylactic gastrectomy. In absence a validated biopsy protocol, we modeled bioptic diagnostic yield on basis topographic distribution foci in series 10 gastrectomies CDH1-mutation carriers. Complete histologic examination was performed all cases, 1817 slides were evaluated for presence situ, intramucosal, or submucosal carcinoma. Detailed maps determined density foci. On number...
To study the molecular basis of vascular remodeling in pulmonary hypertension, we developed an experimental system which male Sprague-Dawley rats were exposed to hypoxia for up 3 wk. Both right ventricular systolic pressure and gravimetric index hypertrophy higher wk than those age-matched control (P < 0.01), indicating that hypertension was established under conditions used. examine possible involvement platelet-derived growth factor (PDGF) caused by hypoxia, cloned rat PDGF A- B-chain cDNA...
The transcription factor Nrf2 regulates the expression of detoxifying and antioxidant genes. Three polymorphisms gene have been reported. We attempted to clarify relationship between polymorphism chronic gastritis in a Japanese population. study was performed 159 patients with no evidence gastric malignancy on upper gastrointestinal endoscopy (mean age, 62.03 years; male:female ratio, 102:57; peptic ulcer diseases 69 patients, Helicobacter pylori (H. pylori) positivity 73.0%). employed...
Dysplasia in Barrett esophagus has been recognized to be morphologically heterogenous, featuring adenomatous, foveolar, and hybrid phenotypes. Recent studies have suggested a tumor suppressor role for CDX-2 the metaplasia-dysplasia-carcinoma sequence. The phenotypic stability of neoplastic progression different types dysplasias not evaluated. Thirty-eight endoscopic mucosal resections with dysplasia and/or intramucosal carcinoma (IMC) arising were evaluated expression MUC5AC, MUC6, MUC2,...
Objectives To determine the prevalence and location of recurrent thoracolumbar intervertebral disc extrusion ( T ‐ L IVDE ) after hemilaminectomy with prophylactic fenestration PF to document ‐related complications. Study Design Retrospective case series. Sample population Chondrodystrophic dogs (n = 793). Methods In 662 successfully recovered (>1 year follow‐up), that required a 2nd surgery clinical signs improved without was evaluated. Prevalence second extrusions SDE s) within 11‐ 4...
Serum hyaluronic acid (sHA) is a serum biomarker for knee osteoarthritis (OA). Although sHA concentration elevated in patients with OA, the relationship between and disease progression remains unclear. We examined radiographic of OA cohort individuals followed 5 years.We prospectively enrolled 444 measured their concentrations at baseline. Anterior-posterior weight bearing radiographs were obtained baseline 5-year endpoint. Osteoarthritic changes classified according to Kellgren-Lawrence...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome unsolved problems on dilute polymer solutionsHiroshi FujitaCite this: Macromolecules 1988, 21, 1, 179–185Publication Date (Print):January 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ma00179a036https://doi.org/10.1021/ma00179a036research-articleACS PublicationsRequest reuse permissionsArticle Views276Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the...