A5101893375- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Erythropoietin and Anemia Treatment
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infant Nutrition and Health
- Astrophysics and Star Formation Studies
- Cardiac Arrest and Resuscitation
- Clinical Nutrition and Gastroenterology
- Nitric Oxide and Endothelin Effects
- Heart Failure Treatment and Management
- Ultrasound and Hyperthermia Applications
- Obstructive Sleep Apnea Research
- Advanced MRI Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
Tohoku University
2012-2024
Yokohama University of Pharmacy
2019-2022
Tohoku University Hospital
2022
Oita University
2021
Meijo University
2020
Fukuda Denshi (Japan)
2018
Yokohama Minami Kyosai Hospital
2018
Impact
2016
Sendai University
2011
Chiba University
2006
Recent studies have suggested that endogenous erythropoietin (Epo) plays an important role in the mobilization of bone marrow-derived endothelial progenitor cells (EPCs). However, it remains to be elucidated whether Epo system exerts protective effects on pulmonary hypertension (PH), a fatal disorder encountered cardiovascular medicine.A mouse model hypoxia-induced PH was used for study. We evaluated right ventricular systolic pressure, hypertrophy, and vascular remodeling mice lacking...
We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR contributes angiogenesis response ischemia. EpoR(-/-)-rescued mice lack most organs including cardiovascular except erythroid-lineage cells. Two weeks after femoral artery ligation, blood flow recovery, activation of VEGF/VEGF system, and mobilization endothelial...
Background: Although myocardial fibrosis plays an important role in the progression of heart failure (HF), its prognostic impact still remains to be clarified. Methods and Results: A total 172 consecutive patients with chronic HF, who underwent cardiac catheterization endomyocardial biopsy between January 2001 September 2008, were examined. They divided into 2 groups: HF preserved ejection fraction (HFPEF; left ventricular [LVEF] ≥50%, n=81); reduced LVEF (HFREF; <50%, n=91). The collagen...
Background: Direct evidence for Rho-kinase activation in patients with pulmonary hypertension (PH) is still lacking. Methods and Results: activity circulating neutrophils was examined by determining the ratio of phosphorylated/total forms myosin-binding subunit, a substrate Rho-kinase, 40 consecutive PH healthy controls. Next, expression isolated human lung tissues (5 idiopathic arterial [IPAH], 5 controls) vascular reactivity small arteries vitro (4 IPAH, 4 controls). significantly...
The time course and factors correlating with ventricular tachyarrhythmias (VTs) after introduction of corticosteroid therapy in patients cardiac sarcoidosis remain to be elucidated.We examined 68 consecutive the Tohoku University Hospital from October 1998 September 2014 (age: 57±11 years old; male:female 18:50) evaluated VTs initiation steroid therapy. were defined as documented tachycardia or fibrillation lasting for more than 30 seconds resulting cardiovascular collapse, appropriate...
Mobilization of stem cells/progenitors is regulated by the interaction between stromal cell-derived factor-1 (SDF-1) and its ligand, CXC chemokine receptor 4 (CXCR4). Statins have been suggested to ameliorate pulmonary arterial hypertension (PAH); however, mechanisms involved, especially their effects on progenitors, are largely unknown. Therefore, we examined whether pravastatin ameliorates hypoxia-induced PAH in mice, if so, which type progenitors what mechanism(s) involved.Chronic hypoxia...
The current status of primary prevention sudden cardiac death (SCD) with implantable cardioverter defibrillator (ICD) in patients heart failure reduced ejection fraction remains to be fully elucidated Japan.In the chronic (CHF) cohort study, CHART-2 Study, we enrolled 2,778 consecutive NYHA class II-III. According Japanese Circulation Society guideline prophylactic ICD, divided them into 3 groups: group A, I indication; B, IIa; and C, no indication. During (median) 3.2-year follow-up, 79...
Background: After the East Japan Earthquake disaster there may have been a deterioration of patients with cardiovascular diseases. Methods and Results: We examined data from 189 consecutive implanted devices for 6-month period before after Earthquake. In 170 defibrillators, number who experienced tachyarrhythmias increased significantly (28±5 vs. 34±3 patients/month, P<0.05). 74 biventricular pacemakers, heart failure hospitalizations (1.2±1.0 2.7±1.2 Conclusions: The unfavorably affected...
BackgroundCardiac resynchronization therapy (CRT) is effective for patients with heart failure a QRS duration (QRSd) > 150 milliseconds (ms). However, its beneficial effect appears to be limited those "mid-range" QRSd (120–149 ms). Recent studies have demonstrated that modifying the left ventricular end-diastolic volume (LVEDV), modified QRSd, improves prediction of clinical outcomes CRT.ObjectiveTo investigate impact in regarding efficacy CRT.MethodsWe conducted retrospective, multi-center,...
he new classification of pulmonary hypertension (PH) has been recently updated, 1 in which 5 major categories the disorder have classified.Among them, arterial (PAH, class 1) and chronic thromboembolic (CTEPH, 4) are characterized as having similar hemodynamic circulation despite their different pathological vascular structures.Optical coherence tomography (OCT) is an interferometerbased optical imaging modality that produces a 2-dimensional image scattering from internal tissue...
Pulmonary hypertension (PH) still remains a serious disease, for which the plasma level of brain natriuretic peptide (BNP) and hemodynamic variables (eg, cardiac index: CI) are established prognostic factors. The aim present study was to identify new additional factors disorder improve management PH.The cohort comprised 136 consecutive PH patients admitted hospital from 1974 2008, all whom were closely followed every 6-12 months. During follow-up period 53.5+/-4.5 [SEM] months, 47 died...
Atrial fibrillation (AF) frequently coexists with heart failure preserved ejection fraction (HFpEF), and clinical outcomes of patients AF vary depending on its subtype. While progression characterized by the transition from paroxysmal to persistent is sometimes observed, incidence impact in HFpEF remain be explored.
Background: Heart failure (HF) is a complex clinical syndrome, resulting from structural and/or functional cardiac disease. The aim of this study was to determine whether the activity Rho-kinase, which has been identified as an important therapeutic target cardiovascular disease, enhanced in HF patients. Methods and Results: Total phosphorylated forms myosin binding subunit (t-MBS p-MBS), substrate were measured on western blotting circulating leukocytes, p-MBS/t-MBS ratio defined index...
Background Both endocardial trigger elimination and epicardial substrate modification are effective in treating ventricular fibrillation (VF) Brugada syndrome. However, the primary approach characteristics of patients who respond to ablation remain unknown. Methods Among 123 symptomatic syndrome (VF, 63%; syncope, 37%), was performed 21 VF/electrical storm patients, majority whom were resistant antiarrhythmic drugs. Results Careful mapping revealed that 81% had no specific findings, whereas...
Background: Several studies have demonstrated the importance of mechanoelectrical interaction in patients with surgically corrected tetralogy Fallot. However, significance atrioventricular conduction disturbance, that is PR interval prolongation, on adverse cardiac events those remains to be elucidated. Methods: We examined electrocardiograms at baseline and their temporal change a total 176 repaired Fallot (49% men; median age, 17.4 years). Then, we evaluated correlation right ventricular...
Optimal therapy for patients resuscitated from out-of-hospital cardiac arrest (OHCA) who are not found to have structural heart disease remains be established, especially regarding the use of implantable cardioverter-defibrillators. Coronary artery spasm (CAS) and lethal ventricular arrhythmias important causes OHCA.In 47 consecutive OHCA survivors without had fully recovered (M/F 44/3, 43±13 years.), we performed dual induction tests, including acetylcholine provocation test first followed...
Sleep-disordered breathing (SDB) has been reported to influence mortality and occurrence of ventricular tachyarrhythmia in patients with chronic heart failure (CHF). It remains be elucidated, however, whether respiratory therapy (RT) can affect the fatal CHF SDB.We prospectively examined severity SDB was associated cardiac events and, if so, RT for improved prognosis. We enrolled 95 stable CHF, whom on overnight polygraphy. The quantified using apnea-hypopnea index (AHI). All AHI ≥10 (n=42)...
Although hypoxia and ischemia are known to be involved in the pathogenesis of cardiovascular disease, specific therapeutic targets still remain elusive. To address this important issue, we have performed 2 series experimental studies, aiming at erythropoietin (Epo)/Epo receptor (EpoR) based on following backgrounds. Epo has long been regarded as a hematopoietic hormone that acts exclusively proliferation differentiation erythroid progenitors. recent studies demonstrated EpoR is expressed...