A5004246908- Drug Transport and Resistance Mechanisms
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Pharmacogenetics and Drug Metabolism
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Ion channel regulation and function
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Muscle metabolism and nutrition
- Diabetes Treatment and Management
- Cardiac Arrhythmias and Treatments
- Amino Acid Enzymes and Metabolism
- Glycogen Storage Diseases and Myoclonus
- Pulmonary Hypertension Research and Treatments
- Metabolism, Diabetes, and Cancer
- Antibiotics Pharmacokinetics and Efficacy
- Advanced MRI Techniques and Applications
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Cardiomyopathy and Myosin Studies
Kansai Medical University
1996-2025
Fukushima University
2022-2024
Yamasa Corporation (Japan)
2015-2024
Shimadzu (Japan)
2014-2024
The Japanese Society of Gastroenterological Surgery
2024
Obihiro University of Agriculture and Veterinary Medicine
2023
AbbVie (Japan)
2015-2021
ABB (Japan)
2015-2021
Nishida Hospital
2017-2020
Food Research Institute
2002-2017
Recent studies have suggested that endogenous erythropoietin (Epo) plays an important role in the mobilization of bone marrow-derived endothelial progenitor cells (EPCs). However, it remains to be elucidated whether Epo system exerts protective effects on pulmonary hypertension (PH), a fatal disorder encountered cardiovascular medicine.A mouse model hypoxia-induced PH was used for study. We evaluated right ventricular systolic pressure, hypertrophy, and vascular remodeling mice lacking...
Background: Radiofrequency catheter ablation (RFCA) can eliminate most idiopathic repetitive monomorphic ventricular tachycardias (RMVTs) originating from the right and left outflow tracts (RVOT, LVOT). Here, we describe electrophysiological (EP) findings of a new variant RMVT mitral annulus (MAVT). Methods Results: MAVT was identified in 35 patients out 72 consecutive RMVTs May 2000 to June 2004. All underwent an EP study RFCA. The sites origin were grouped into four groups according...
<title>Abstract</title> BACKGROUND Colorectal cancer (CRC) remains a significant cause of mortality worldwide. Although FOBT has demonstrated efficacy in reducing colorectal cancer-related deaths, it limitations. We explored an innovative and user-friendly screening method using gas sensors installed toilets. METHODS developed that can be conducted demonstration experiment these to monitor individuals their bathrooms. The involved 101 patients, 50 polyp 90 healthy who were registered...
Octadecapeptides carrying a ferrocene moiety at the molecular terminal were self-assembled on gold, and long-range electron transfer from to gold was investigated by electrochemical methods. Effects of dipole moment helical peptides, linkers connecting peptide chromophores introduced into side chains discussed. Cyclic voltammetry monolayers in an aqueous solution revealed that over 40 Å occurred along molecule. Chronoamperometry showed should be ascribed hopping mechanism with use amide...
Background The incidence of stroke in patients suffering atrial fibrillation (AF) is increased when left enlargement occurs. Recently, the platelet adhesive molecule, von Willebrand factor (vWF), located endocardium, has been shown to be with a variety heart diseases compared who have no cardiac problems. Methods and Results We investigated expression vWF mRNA protein endocardium as possible prothrombotic alteration AF association structural remodeling. Atrial appendage specimens were...
Introduction: Mutations of lamin A/C gene ( LMNA ) cause dilated cardiomyopathy (DCM) with atrioventricular (AV) conduction defect, although the electrophysiological and histological profiles are not fully understood. Methods Results: We analyzed a large Japanese family (21 affected 203 unaffected members) DCM AV block. The responsible mutation IVS3–10A>G was novel caused an aberrant splicing. first clinical manifestation low‐grade block or atrial fibrillation (AF), which developed in...
AIMTo compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection (ESD). METHODSData were obtained from a total 26 patients.Fourteen patients randomized to group 12 group.Patients administered either 20 mg or 30 per day after ESD.Endoscopic images just ESD, 8, 28 used for evaluation shrinking rate ESD ulcers.The rates incidence delayed bleeding compared between 2 groups. RESULTSThe 8 [vonoprazan
Chitinase C from Streptomyces griseus HUT6037 was discovered as the first bacterial chitinase in family 19 other than chitinases found higher plants. comprises two domains: a chitin-binding domain (ChBDChiC) for attachment to chitin and chitin-catalytic digesting chitin. The structure of ChBDChiC determined by means 13C-, 15N-, 1H-resonance nuclear magnetic resonance (NMR) spectroscopy. conformation its backbone comprised β-sheets composed three antiparallel β-strands, respectively, this...
Coronary arterial pressure and flow are known to influence left ventricular (LV) diastolic distensibility, but the of coronary venous is unknown. To test hypothesis that increased leads an increase in LV wall volume a decrease we studied excised, blood-perfused isovolumic dog hearts without pericardium. In protocol I (n = 8), raise right atrium (RA) ventricle (RV) was by height blood reservoir connected with cannula opened both RA RV. II 7), isolate effect RV enlargement on distensibility...
Estragon and thyme extracts showed potent inhibitory activities against chemical mediator release from rat basophilic leukemia RBL-2H3 cells. 7-Methoxycoumarin was isolated estragon, 5,4′-dihydroxy-6,7,3′-trimethoxyflavone, 5,4′-dihydroxy-6,7,8,3′-tetramethoxyflavone, 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone luteolin were as active components. Structure-activity relationship studies among the isolates their related compounds indicated that oxygen-containing functional group at 7-position of...
Cytosolic Ca2+ and protein kinase C (PKC) may regulate the myogenic contraction of arterial myocytes. The role these second messengers is examined in skeletal muscle small arteries, which have strong activity, mesenteric weak activity. vessels were isolated cannulated. inner diameter was measured with a video-digitizing system. concentration assessed by fura 2. Skeletal arteries dilated from 122 +/- 6 to 153 microm immediately after transmural pressure change 40 100 mmHg constricted 121 5...
The current reperfusion strategy in Japan for acute myocardial infarction (AMI) is that the majority of early arrival patients are treated with primary percutaneous coronary intervention (PCI). However, efficacy PCI, intravenous thrombolysis (IV-T), intracoronary (IC-T) and rescue PCI has not been compared clinical situation. In present study, 3,258 cases AMI 1992-2000 from data base Miyagi Study Group were analyzed. These hospitalized within 6 h onset symptoms. IV-T IC-T initially performed...