A5100734733- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Cardiac Imaging and Diagnostics
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Pelvic floor disorders treatments
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Coronary Artery Anomalies
- Esophageal and GI Pathology
- Lymphoma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Glycosylation and Glycoproteins Research
- Glioma Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Metastasis and carcinoma case studies
- Kawasaki Disease and Coronary Complications
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
Fukushima Medical University
2016-2025
Iwate Medical University
2007-2024
Environmental Research Institute
2024
Kumamoto University
2018-2024
Kitasato University
2014-2023
Gifu Pharmaceutical University
2023
Ricoh (Japan)
2023
Otsuka (Japan)
2023
Niigata University
2010-2021
Satou Hospital
2016-2020
The presence of nervous tissue specific S100 protein was studied immunohistochemically in 47 cases malignant melanoma and 25 pigmented nevi various types by peroxidase-antiperoxidase immunoenzyme method on routine paraffin sections the surgical specimens. Of melanoma, 44 were positively stained for protein. intensity immunostaining suggested to be inversely proportional amount melanin pigment. In ten 12 amelanotic melanomas, immunoreaction tumor cells stronger than that normal Bergmann glial...
Abstract To investigate the frequency of bcl ‐2 oncogene protein expression in small cell lung carcinoma (SCLC), immunohistochemical staining with a mouse‐anti‐human monoclonal antibody, ‐2/124, was carried out on 60 formalin‐fixed, paraffin‐embedded SCLC samples obtained from surgical biopsy, and autopsy cases. detected 54 SCLCs. In 47 cases, more than half tumour cells stained positively. The intensity comparable to that infiltrating lymphocytes 37 but varied area even cell. Negative data...
Infiltration of T-zone histiocytes (Langerhans' cells and their precursors) macrophages was investigated by immunohistochemical methods with the use anti-S100 protein anti-lysozyme antibodies in 40 Stage Ia cases adenocarcinoma lung. Varying population densities S100+ were demonstrated 31 (77.5%) adenocarcinomas; however, lysozyme+ found almost equal quantities all adenocarcinoma. The distribution clearly different from that macrophages. Namely, former mainly interspersed among tumor cells,...
Abstract The optimal source of stem cells for regenerative medicine is a major question. Embryonic (ES) have shown promise pluripotency but ethical issues and potential to form teratomas. Pluripotent been produced from skin by either viral‐, plasmid‐ or transposon‐mediated gene transfer. These termed induced pluripotent iPS cells. may also malignant are inefficiently produced. not be suited individualized therapy, since they can undergo immunologic rejection. To address these fundamental...
Eight cases with malignant histiocytosis (MH), two systemic Letterer-Siwe disease, and one case sarcomatous variant of MH were studied clinicopathologically. Characterization neoplastic histiocytes was performed by immunohistochemical staining for S100 protein, lysozyme, nonspecific cross reacting antigen carcinoembryonic (NCA). The characteristics S100+lys-NCA- in eight disease S100-lys+NCA+ the MH. considered to have derived from a specific S100+ histiocytic cell lineage (T-zone histiocyte...
Six years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by Japan Society Obstetrics and Gynecology Association Obstetricians Gynecologists, third revised published in 2017. 2017 Guidelines includes 10 additional clinical questions (CQ), brings total to 95 CQ (12 on infectious disease, 28 oncology benign tumors, 27 endocrinology infertility healthcare women). Currently a consensus has been reached therefore objective this report is present...
Abstract Background Histopathology of muscularis externa in primary esophageal motility disorders has been characterized previously. We aimed to correlate the results high‐resolution manometry with those histopathology. Methods During peroral endoscopic myotomy, muscle biopsy was performed patients disorders. Immunohistochemical staining for c‐kit assess interstitial cells Cajal ( ICC s). Hematoxylin Eosin and Azan‐Mallory were used detect atrophy, inflammation, fibrosis, respectively. Key...
To obtain an adequate quality and quantity of DNA from formalin-fixed paraffin-embedded tissue, six different extraction methods were compared. Four used deparaffinization by xylene followed proteinase K digestion phenol-chloroform extraction. The temperature the steps was changed to higher yields improved extracted DNA. remaining two microwave heating for deparaffinization. best method consisted irradiation, protein with at 48°C overnight, no further purification steps. By this method,...
Thirty‐one cases of Hodgkin's disease were examined for the occurrence Epstein‐Barr virus (EBV) genome by using polymerase chain reaction (PCR) DNA in formalin‐fixed paraffin‐embedded tissues and situ hybridization technique. The subdivided into 17 nodular sclerosis (NS), nine mixed cellularity (MC), four lymphocyte predominance (LP), one case depletion (LD). EBV was detected eight including NS, three MC LP. sensitivity PCR higher than that Southern blot from fresh frozen tissue, because Bam...
In the present study, multislice spiral computed tomography (MSCT), which allows non-invasive assessment of coronary artery plaque, was used to compare CT density plaque between patients with acute syndrome (acs) and those stable angina (sa).MSCT performed in 20 ACS (17 myocardial infarction, 3 unstable angina) 22 SA. The presence defined on basis multiplanar reformation axial images. At least 4 regions interest were then placed within minimum measured expressed as Hounsfield units (HU)....
Background The diagnosis of acute coronary syndrome (ACS), especially non-ST-elevation myocardial infarction and unstable angina in the emergency department (ED) still remains a challenge. Multislice computed tomography (MSCT) allows assessment not only artery stenoses occlusions, but also plaques perfusion status. Methods Results MSCT was performed 31 patients who were admitted to ED because chest pain persisting at least 30 min non-diagnostic ECG changes normal serum enzyme concentrations....
Twenty-four cases of thymic epithelial tumors, including 18 thymoma, five squamous cell carcinoma, and one case undifferentiated were studied immunohistochemically using monoclonal antibody Leu-7 (HNK-1) antikeratin antibody. Seven non-neoplastic tissues also studied. stained cells in the outer cortex normal thymus, both medulla thymus. Seventeen thymomas carcinoma focally or diffusely with Leu-7, some showing cortical medullary differentiation as seen On other hand, none carcinomas Leu-7....
Thirty cases of immunologically determined and histologically diagnosed immunoblastic lymphadenopathy (IBL), angioimmunoblastic (AILD), IBL-like T-cell lymphoma were clinicopathologically reviewed. Clinical manifestations laboratory findings did not reveal significant differences in these three groups. IBL, AILD, showed a spectrum histologic changes, which proliferation pale cells was critical diagnostic point for the malignancy. Immunostaining their subsets revealed that 3 21 T4+ phenotype...
Introduction Myosin-9 (MYH9) belongs to the myosin superfamily of actin-binding motor protein. Recently, MYH9 has been thought be associated with cancer cell migration, invasion, and metastasis. The aims this study were immunohistochemically examine expression in surgically resected non-small lung (NSCLC), evaluate its correlations clinicopathological parameters prognosis patients. Methods was studied 266 consecutive NSCLCs, associations evaluated. Kaplan-Meier survival analysis Cox...