A5057258381- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Intraocular Surgery and Lenses
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Corneal surgery and disorders
- Urinary and Genital Oncology Studies
- Ophthalmology and Visual Impairment Studies
- Renal and Vascular Pathologies
- Urinary Tract Infections Management
- Cancer Immunotherapy and Biomarkers
- Hormonal Regulation and Hypertension
- Glaucoma and retinal disorders
- Cancer Research and Treatments
- Pediatric Urology and Nephrology Studies
- Nanoplatforms for cancer theranostics
- Urologic and reproductive health conditions
- Cancer Cells and Metastasis
- Hormonal and reproductive studies
- Reproductive Biology and Fertility
- Adrenal and Paraganglionic Tumors
Fukushima Medical University
2016-2025
University of Miyazaki Hospital
2021
University of Miyazaki
2021
Kyoto Prefectural University of Medicine
2020-2021
John Wiley & Sons (United States)
2018-2019
University of Oxford
2019
Interface (United Kingdom)
2018-2019
Hudson Institute
2018
Indianapolis Zoo
2017
Hayashi Eye Hospital
2014-2016
Metastatic renal cell carcinoma (RCC) is a tumor entity with poor prognosis due to limited therapy options. Tyrosine kinase inhibitors (TKI) represent the standard of care for RCCs, however significant proportion RCC patients develop resistance this therapy. Interleukin-6 (IL-6) considered be associated in RCCs. We therefore hypothesized that TKI and IL-6 secretion are causally connected. first analyzed expression after treatment cells specimens. Cell proliferation signal transduction...
Introduction Postoperative recurrence of chromophobe renal cell carcinoma is rare, and its metastatic process remains unclear. We here report a case solitary metastasis in the residual ureter detected 9 years after primary surgery discuss possible mechanism based on our immunohistochemical study. Case presentation A 67‐year‐old woman received nephrectomy for left tumor, which was diagnosed as with urinary collecting system invasion. Nine postoperatively, tumor found ureteral stump surgically...
Effects of stable ATP analogs such as alpha,beta-methylene (alpha,beta-mATP) and beta,gamma-methylene (beta,gamma-mATP) on release contractile response were evaluated in the vas deferens ileal longitudinal muscles guinea pig. In these smooth muscles, administration alpha,beta-mATP (10, 30 or 100 microM) produced an accompanied by a transient contraction, but ADP (30 adenosine failed to elicit both contraction. However, peak responses contraction (100 appeared around 2 min 2.62 sec,...
The aim of the present study is to elucidate factors contributing early recovery urinary continence after robot-assisted laparoscopic radical prostatectomy (RARP) from perspective urethral and vesical anatomical features RARP.Sixty consecutive patients undergoing RARP also underwent pre- postoperative urethrovesicography (UVG). Both UVG evaluated posterior-urethral angle position urethrovesical junction. Postoperative was performed 7 days membranous length (MUL) degree atony external...
Diagnosis of peritoneal metastasis in gastric cancer (GC) is essential for determining appropriate therapeutic strategies and avoiding non-essential laparotomy or gastrectomy. Recently, a variety activatable fluorescence probes that can detect enzyme activities have been developed imaging. The aim this study was to identify the key involved GC. enzymatic activity gamma-glutamyl transpeptidase, dipeptidyl peptidase IV, β-galactosidase (β-Gal) assessed lysates prepared from preserved human GC...
<h3>Aim</h3> To compare monocular and binocular visual function between eyes with a distance-dominant diffractive multifocal intraocular lens (IOL) low addition power (+2.5 dioptres (D)) monofocal IOL. <h3>Methods</h3> Sixty-four of 32 patients undergoing implantation IOL (Alcon ReSTOR +2.5 D, SN6AD2) D 64 age-matched (SN60WF) were recruited. At 3 months postoperatively, acuity (VA) from far to near distances, contrast VA that glare (glare VA), disability halo symptoms evaluated....
The aim of this study was to examine the recent status intraocular lens (IOL) dislocation according a classification system based on vertical position, as well surgical techniques and outcomes IOL exchange surgery.The medical records 230 eyes from 214 consecutive patients who experienced underwent surgery between 2006 2014 were reviewed. Vertical sites observed preoperatively under operating microscopy examined, along with exchange.Dislocation included (1) anterior chamber (12.2 %), (2)...
To examine whether intraocular lens (IOL) power prediction error (PE) after cataract surgery differs according to patient age.Prospective cohort study.We consecutively enrolled 75 eyes of patients 59 years age or younger, and 150 in each 3 groups (60-69, 70-79, 80-89 years), for whom phacoemulsification implantation a single-piece acrylic IOL was planned. The calculated using the optimized SRK/T formula. Objective refraction measured an autorefractometer at approximately months...
Purpose: The aim of the present study is to investigate effect pad use for postprostatectomy incontinence on urinary quality life (QoL) after robot-assisted laparoscopic radical prostatectomy (RARP) in early postoperative period. Methods: Ninety patients underwent RARP simultaneously completed International Consultation Incontinence Questionnaire-Short Form (ICIQ-SF) and modified questionnaire that evaluated QoL a 24-hour test. Pad was also assessed by form, size, number exchanges per day,...
This report describes a rare case of an 86-year-old man with indwelling urethral catheter who developed severe abdominal pain and was diagnosed intraperitoneal urinary bladder perforation. A home-visiting nurse suspected obstruction performed exchange. However, irrigation could not subsequently be performed. Computed tomography the abdomen pelvis after transurethral perfusion contrast medium demonstrated extravasation material into peritoneal cavity. Furthermore, Foley balloon positioned in...
We report a case of clear cell carcinoma occurring in the prostate with Zinner syndrome 64-year-old man. Based on immunohistochemical findings, it was concluded that this tumor represented primary renal-type arising prostate. After receiving radical cystoprostatectomy, he treated tyrosine kinase inhibitor (TKI) therapy for local recurrence accordance protocol renal (RCC) treatment, because microarray cluster analysis using resected sample demonstrated present belonged to group RCC.
Abstract Enzalutamide (Enz) is a second‐generation androgen receptor (AR) antagonist for castration‐resistant prostate cancer (CRPC) therapy, and it prolongs survival time in these patients. However, during Enz treatment, CRPC patients usually acquire resistance to often show cross‐resistance other AR signaling inhibitors. Although glucocorticoid (GR) involved this resistance, the role of GR has not yet been clarified. Here, we report that chronic treatment induced GR‐mediated glucose...
Introduction CHARGE syndrome is a rare disorder that causes congenital abnormalities in multiple organs, including secondary hypogonadism. We report, herein, unique case of with both primary and hypogonadism discuss the possible pathogenesis this patient. Case presentation A 15‐year‐old boy delayed sexual characteristics non‐palpable testes was referred to our hospital. Physical examination detection chromodomain‐helicase‐deoxyribonucleic acid‐binding protein 7 gene mutation confirmed...
Prostate-specific membrane antigen (PSMA)-targeted alpha therapy is considered a promising alternative treatment for metastatic castration-resistant prostate cancer (mCRPC). Though astatine-211 (211At) potentially useful alpha-emitter producible by cyclotrons, its clinical application has been limited instability and tendency to deastatination in vivo. To overcome these challenges, we developed [211At]At-NpG-PSMA, novel PSMA ligand with neopentyl-glycol structure that enhances vivo stability...
Accurate diagnosis of peritoneal metastasis in gastric cancer (GC) is important to determine the appropriate treatment. This study aimed examine whether matrix metalloprotease-14 (MMP-14) was a candidate enzyme fluorescence imaging for GC.GC and normal (NP) tissues from 96 20 patients, respectively were evaluated MMP-14 expression. Live cell GC lines (NUGC4, MKN45, MKN74, HGC-27, Kato-III) performed using MMP-14-activatable probe; BODIPY-MMP. Furthermore, overall survival (OS) calculated all...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer that expressed in natural killer cells, whose cytotoxicity activated by interferon (IFN). We investigated the effect of suppressor cytokine signaling (SOCS) 3 on expression TRAIL receptors (DR4) and sensitivity renal cell carcinoma (RCC) cells.Vector expression, RNA interference IL-6 receptor antibody tocilizumab were used to investigate functional role SOCS3 DR4 expression....