A5101920000- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Nephrotoxicity and Medicinal Plants
- Cytomegalovirus and herpesvirus research
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Urological Disorders and Treatments
- Photodynamic Therapy Research Studies
- Bladder and Urothelial Cancer Treatments
- Hormonal and reproductive studies
- Cancer and Skin Lesions
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Soft tissue tumor case studies
- Herpesvirus Infections and Treatments
- Escherichia coli research studies
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Immune Cell Function and Interaction
Okayama University
2019-2025
Asahikawa Kosei Hospital
2023-2024
Fukushima Medical University
2012-2023
Osaka Nishi Clinic
2023
Asahikawa Medical University
2013-2022
Okayama University Hospital
2021
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Johannes Gutenberg University Mainz
2017
Indianapolis Zoo
2017
Sensorineural hearing loss (SNHL) is the most common congenital disease. Longitudinal studies of infants with cytomegalovirus (CMV) infection have demonstrated an association between CMV and SNHL. However, because lack suitable neonatally collected specimens, proportion CMV-associated SNHL has not been defined, nor relationship major genetic causes SNHL, such as mutations in GJB2 gene.Sixty-seven children severe were analyzed for human herpesvirus 6 (HHV-6) infections mutations. DNA...
Metastatic renal cell carcinoma (RCC) is a tumor entity with poor prognosis due to limited therapy options. Tyrosine kinase inhibitors (TKI) represent the standard of care for RCCs, however significant proportion RCC patients develop resistance this therapy. Interleukin-6 (IL-6) considered be associated in RCCs. We therefore hypothesized that TKI and IL-6 secretion are causally connected. first analyzed expression after treatment cells specimens. Cell proliferation signal transduction...
Activation of STING signaling plays an important role in anti-tumor immunity, and we previously reported the effects through accumulation M1-like macrophages tumor tissue treated with a agonist. However, myeloid cells express SIRPα, inhibitory receptor for phagocytosis, its receptor, CD47, is overexpressed various cancer types. Based on our findings that breast patients highly expressed CD47 have poor survival, evaluated therapeutic efficacy underlying mechanisms combination therapy ligand...
Ectopic bone marrow (eBM) holds tremendous potential as an artificial organ, serving not only in stem cell transplantation therapies but also a controlled experimental system for analyzing cellular dynamics and interactions between cells the matrix during formation, maintenance, aging of (BM). Although morphogenetic protein (BMP)-2 has been reported to induce eBM it remains unproven whether BMP-2 induced (BMP-eBM) can provide functional BM niche that is comparable native long bones (LB-BM)....
Background: The expression of c-Met and its ligand HGF plays a critical role in cell proliferation is involved numerous malignancies. Because NK/T-cell lymphoma remain unclear, we studied the function cells. In addition, investigated possibility that could as tumor-associated antigen for helper T lymphocytes (HTLs).Methods: We evaluated whether were expressed capacity predicted HTL epitopes to induce antitumor responses vitro. inhibitor was ability inhibit TGF-β production tumor subsequently...
Immunoglobulin G4 (IgG4)-related lung disease is a in which IgG4-positive plasma cells and lymphocytes infiltrate tissues along with immunohistochemically evident fibrous interstitial proliferation the background, addition to hyper-IgG4 disease. The diagnosis of this can be difficult. Here, we report 2 cases IgG4-related that was difficult differentiate from malignant tumors because both had pulmonary lesions showing high standardized uptake values (SUV) on positron emission tomography...
Most tumorous lesions of the esophagus are esophageal cancers. Benign primary tumors uncommon, and account for approximately 2% all tumors. More than 80% benign leiomyomas, with schwannomas being rare. A 55-year-old woman visited our internal medicine department complaints palpitations discomfort during swallowing. chest computed tomography scan showed a lobulated tumor (75 × 57 80 mm) in upper to middle mediastinum, homogenous inner opacity, compressing esophagus. Upper gastrointestinal...
Tumor immune escape has been a major problem for developing effective immunotherapy. The human leukocyte antigen G (HLA-G) is non-classical MHC class I molecule whose primary function to protect the fetus from mother's system. While HLA-G hardly found in normal adult tissues, various tumor cells are known express it, aiding their Thus, an attractive immunotherapy target. CD4+ helper T lymphocytes (HTLs) play important role reaction against tumors by assisting generation and persistence of...
Interferon (IFN)‐α is one of the most commonly used agents in immunotherapy for patients with advanced stage renal cell carcinoma. However, because drug resistance to IFN‐α, its benefits are limited. In this study, we examined whether repression suppressor cytokine signaling (SOCS) proteins, which involved IFN‐induced pathway, can overcome IFN The effect IFN‐α on SOCS3 expression and proliferation was using IFN‐resistant 786‐O IFN‐sensitive ACHN lines. effects SOCS3‐targeted siRNA xenografts...
Using a rat BOO model, we determined whether α1-adrenoceptor (AR) antagonists (silodosin, prazosin) improve the bladder storage function by reducing afferent input from lower urinary tract.Male rats received partial outlet obstruction or sham surgery were used. Four weeks following surgery, their voiding behavior was measured in metabolic cage. BOO-rats administered silodosin, prazosin vehicle for 2 subcutaneously using osmotic pump. At post-drug condition, again. The L6 spinal cord removed...
The aim of the present study is to elucidate factors contributing early recovery urinary continence after robot-assisted laparoscopic radical prostatectomy (RARP) from perspective urethral and vesical anatomical features RARP.Sixty consecutive patients undergoing RARP also underwent pre- postoperative urethrovesicography (UVG). Both UVG evaluated posterior-urethral angle position urethrovesical junction. Postoperative was performed 7 days membranous length (MUL) degree atony external...
ABSTRACT A total of 21 clones acyclovir (ACV)-resistant (ACV r ) herpes simplex virus type 1 (HSV-1) and 23 penciclovir (PCV)-resistant (PCV HSV-1, emerging during serial passages in the presence ACV or PCV, were isolated under conditions excluding contamination resistant mutants starting culture, their mutations thymidine kinase (TK) DNA polymerase (DNA Pol) genes analyzed comparatively. Mutations TK from consisted 50% single nucleotide substitutions frameshift mutations, while...
The present study investigated the effects of bladder outlet obstruction (BOO) on muscarinic receptor (MR)-coupled RhoA/Rho-kinase (ROK) pathway in detrusor smooth muscle rat.Detrusor samples were obtained from bladders after 4 weeks BOO and also sham-operated control rats. Contractile responses to electrical field stimulation (EFS) 1 microM carbachol (Cch) determined isolated strips. ROK inhibitor Y-27632 Cch-induced phasic sustained contractions evaluated. Western blotting was used...
Primary hyperparathyroidism is a rare disease characterized by excessive secretion of parathyroid hormone from adenoma, hyperplasia, or malignancy. The clinical symptoms the condition are those hypercalcemia. Although lesions commonly located in neck region, about 1–2 % cases, ectopically within mediastinum, where surgical excision using cervical approach difficult. principal treatment lesion. However, some patients require additional surgery because recurrence due to intraoperative...
Bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2) have been regarded as the major cytokines promoting bone formation, however, several studies reported unexpected results with failure of formation or resorption these factors. In this study, BMP-2 FGF-2 adsorbed into atellocollagen sponges were transplanted defects in marrow-scarce calvaria (extramedullary environment) marrow-abundant femur (medullary for analysis their vivo effects not only on osteoblasts,...
Mucoepidermoid carcinoma of the lung (MEC) is a tumor low malignant potential bronchial gland origin. MEC and adenoid cystic are both considered to be salivary gland-type neoplasms. MECs comparatively rare with an incidence all cancers. We recently encountered case this type cancer. A 60-year-old man was found have abnormal shadow in left lower field on regular check-up for cancer at his company. Chest radiography CT revealed mass measuring 30 mm diameter field. Bronchoscopy protuberant S9...