A5052617552- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Ear and Head Tumors
- Ear Surgery and Otitis Media
- Head and Neck Anomalies
- Teratomas and Epidermoid Cysts
- Tracheal and airway disorders
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Traumatic Ocular and Foreign Body Injuries
- Salivary Gland Tumors Diagnosis and Treatment
- Vitamin K Research Studies
- Clinical Nutrition and Gastroenterology
- Head and Neck Surgical Oncology
- Cerebral Venous Sinus Thrombosis
- Hemophilia Treatment and Research
- Bone Tumor Diagnosis and Treatments
- Trauma Management and Diagnosis
- Vasculitis and related conditions
- Facial Nerve Paralysis Treatment and Research
- Ophthalmology and Eye Disorders
- Pneumothorax, Barotrauma, Emphysema
- Cancer Immunotherapy and Biomarkers
- Restraint-Related Deaths
Sapporo Higashi Tokushukai Hospital
2021-2024
Asahikawa Medical University
2013-2022
Asahikawa Medical College Hospital
2005-2012
Kushiro Rosai Hospital
2010
Nikko Memorial Hospital
2009
Japanese Red Cross Asahikawa Hospital
2007
Red Cross Hospital
2007
Krankenhaus vom Roten Kreuz
2007
Nasal NK/T-cell lymphoma (NNKTL) is an Epstein-Barr virus (EBV)-associated malignancy and has distinct clinical histological features. However, its genetic features are hitherto unclear. MicroRNAs (miRNAs) play a crucial role in the pathogenesis of several malignancies via regulating gene expression. In this study, we investigated whether specific microRNAs were related to tumor behaviors NNKTL. MiRNA array Quantitative RT-PCR analyses revealed that miR-15a was expressed at much lower level...
Nasal natural killer/T-cell lymphoma (NNKTL) is an Epstein-Barr virus (EBV)-associated malignancy and characterized by local invasion widespread dissemination, with a consequent poor prognosis. Micro-RNAs (miRNAs) play roles in the pathogenesis of several malignancies regulating gene expression have been recently identified as stable entities serum. Here, we investigated value circulating EBV-miRNAs biomarkers for NNKTL. Sera patients NNKTL were subjected to miRNA polymerase chain reaction...
Nasal natural killer (NK)/T cell lymphoma (NNKTL) is associated with Epstein-Barr virus (EBV). The present study analysed gene expression patterns of the NNKTL lines SNK6, SNK1 and SNT8, which are positive for EBV latent membrane protein (LMP)-1, using a complementary DNA array analysis. We found that CD70 was specifically expressed in SNK6 SNT8. Reverse transcription polymerase chain reaction flow cytometric analyses confirmed all 3 lines, but not other EBV-positive NK-cell lines. In vitro...
Nasal natural killer (NK)/T-cell lymphoma (NNKTL) displays unusual clinicopathological features, and the prognosis is very poor, even in early stages of disease. For stage NNKTL, we have developed a novel chemoradiotherapy regimen incorporating arterial infusion chemotherapy, administered via superficial temporal artery, combination with radiotherapy. The consists ifosfamide, carboplatin, methotrexate, peplomycin, etoposide (MPVIC-P). From 2003 to 2011, 12 patients NNKTL were treated MPVIC-P...
Pleomorphic adenoma is a benign tumor that commonly arises from the major salivary glands, such as parotid and submandibular glands. However, they rarely originate nasal cavity. Herein, we describe case of 49-year-old woman who presented with obstruction. Preoperative evaluation revealed giant pleomorphic attached to septum. Transnasal endoscopic removal was successfully performed using specimen retrieval bag. We an complete en-bloc resection large in cavity, There were no complications...
Lipomatous tumors of the salivary glands are very uncommon and there few reports in literature. Histologically, they can be classified into "monophasic" (lipoma component only) or "biphasic" plus epithelial component) tumors. Oncocytic lipoadenoma is a rare benign biphasic lipomatous tumor consisting fatty oncocytic glandular epithelium component. While difficult to diagnose, this histologically good outcomes have been reported with surgical resection. We report case 69-year-old woman who...
This report describes a case of stapedial superstructure fixation with mobile footplate, which is rare occurrence among the ossicular malformations that cause conductive hearing impairment. A 44-year-old man symptoms left-sided impairment since childhood presented to our department. The eardrum was normal, and pure tone audiometry showed three-frequency (500, 1000, 2000 Hz) mean 53.3 dB normal tympanogram result. An abnormal shadow observed on internal side left stapes during...
A 66-year-old man visited our hospital with complaints of pharyngeal discomfort and dysphagia for 3 years. Endoscopic examination revealed a large mass concealing the larynx (Figure 1). Computed tomography 40 × 30 mm located at base epiglottis 2). Although patient did not require emergency airway management, it would have been fatal to develop acute epiglottitis in future. Therefore, was scheduled early removal. Because could be intubated due mass, we performed tracheotomy followed by...
Objective:Unusual clinical course Background:Malignant lymphomas can occur at various sites.Hypopharyngeal tumors are risk for airway obstruction and require rapid diagnosis treatment.Most hypopharyngeal malignancies squamous cell carcinomas; other rare.To date, only a few cases of malignant lymphoma have been reported, its specific characteristics unknown.Herein, we report case right diffuse large B-cell (DLBCL) in 74-year-old man with dysphagia. Case Report:A presented to our hospital...
Synovial sarcoma is a mescenchymal malignancy which accounts for approximately 10% of all soft tissue sarcomas. It usually occurs in the lower limbs young adults, and only 3% synovial sarcomas involve head neck region. As incidence region very low, 11 cases with endolaryngeal localization have been reported world. We report case larynx.The patient was 50-year-old man, complaining swallowing difficulty. The tumor existed left arytenoid pyriform sinus. Histological diagnosis obtained by biopsy...
甲状腺眼症の多くはバセドウ病に合併し,外眼筋肥大などにより眼球突出等の症状をきたし,重篤な際には圧迫性視神経症により失明に至ることもある。視神経症の治療はステロイドパルス療法が第一選択で,治療効果を認めない際には眼窩減圧術が必要となる。今回我々は,甲状腺眼症による視神経症例に対して鼻内内視鏡下での眼窩減圧術を行った2症例を経験したので報告する。症例1は53歳女性で,症例2は51歳女性である。両者ともバセドウ病による甲状腺眼症であり,症例2は2回目の放射線ヨード治療を契機に視神経症を発症した。症例1は右眼,症例2は両眼の急激な視力低下をきたし,ステロイドパルス療法で視力の改善が無いため眼窩減圧術目的に当科に紹介となった。手術は鼻内内視鏡下に両側の眼窩内側壁と下壁内側の骨壁を除去し,骨膜を切開して眼窩内容物を篩骨洞内に逸脱させることで減圧した。両症例とも術後の視力は著明に回復し,およそ一年後に斜視手術を行うことで術後に悪化した複視も消失した。
A case of chondrosarcoma the larynx is reported. 77-year-old man consulted our clinic with hoarseness and mild dyspnea. Bilateral vocal cords were fixed at paramedian line. Magnetic resonance imaging (MRI) computed tomography (CT) demonstrated a mass arising from cricoid cartilage. Biopsy was performed histological examination low grade chondrosarcoma. Basis on these findings clinical symptoms, we total laryngectomy. Fifteen months after surgery, there no any evidence recurrence.
A 62-year-old man suffered a penetrating injury to his left periorbital region with wooden foreign body. He consulted an ophthalmologist and plastic surgeon. was diagnosed conjunctival laceration blowout fracture. His conjunctiva consequently sutured. One month after injury, he our clinic for diplopia. Severly limited trading in the upper lower directions were observed.Computed tomography (CT) Magnetic resonance imaging (MRI) revealed orbital floor When we performed anterior orbitotomy, 50mm...
今回われわれは,緊急気管切開を要した血管浮腫の1例を経験したので報告する。症例は,62歳男性である。頸部,舌の腫脹を主訴に当科を受診した。舌および喉頭に高度な浮腫を認めた。血管浮腫の診断で緊急気管切開を施行したが,術中に呼吸苦の増悪を認め,呼吸停止した。呼吸停止直後輪状甲状膜切開を行い,気道を確保した。アンギオテンシン変換酵素阻害薬,アンギオテンシンII受容体拮抗薬を内服しており血管浮腫の原因薬として疑い休薬し,その後浮腫の再発を認めていない。アンギオテンシン変換酵素阻害薬の副作用として血管浮腫が知られており,稀ではあるが重篤な経過をたどることがあり注意を要する。
BACKGROUND:The nasogastric tube (NGT) is a common medical device, and serious complications associated with NGT insertions are rare. The most complication tracheal insertion; cervical emphysema pneumomediastinum There several methods for confirming the location of NGT, but single method confirmation often inadequate. Confirmation by air insufflation into currently not recommended highly invasive. Here, we report case caused an NGT. CASE REPORT:A 94-year-old woman experienced stroke was...
We report a case of anaplastic thyroid carcinoma the left lateral cervix. A 72-year-old woman undergoing surgery for neck mass behind internal jugular vein was found pathologically to have with partial papillary carcinoma. Although ultrasonography and computed tomography showed no tumor in gland, we conducted total thyroidectomy. No detected specimen recurrence seen two years after treatment. These findings are insufficient, however, diagnose either occult or ectopic
Gunshot wounds are uncommon in Japan because gun possession is illegal. We report a case with shotgun wound to the cheek. The patient was 64-year-old man who accidentally shot while hunting. He alert and had no apparent neurological defects. complained of cheek pain nasal bleeding, bullet observed his left Computed tomography revealed lodged maxillary sinus. removed during endoscopic sinus surgery.
Lingual dermoid cysts are uncommon. To date, there have been twenty reported cases. We report an additional case of lingual cyst. The patient was a sixteen-year-old girl. She referred to our clinic for painful tongue swelling. A firm, tender mass with purulent drainage from the midline dorsum noted. After treatment antibiotics and drainage, size reduced gradually. Eight months later, regrowth observed. totally excised via oral external approach. According histopathological examination, diagnosed as
Isolated fracture of the malleus is a rare condition and often caused by typical events, such as sudden withdrawal finger from ear canal. Here, we report case isolated malleus. The patient, 36-year-old man, put his in left canal pulled it out suddenly, immediately developed hearing loss on same side. His audiogram showed conductive loss, was suspected based medical history. We performed transcanal endoscopic surgery (TEES) order to obtain good view tympanic cavity, fixed with calcium...