A5034637592- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Cancer Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Sarcoidosis and Beryllium Toxicity Research
- Immune Response and Inflammation
- IgG4-Related and Inflammatory Diseases
- Reproductive System and Pregnancy
- Medical Imaging and Pathology Studies
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Vasculitis and related conditions
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
Asahikawa Medical University
2017-2023
University of Pennsylvania
2022
Hokuto Hospital
2017
Activation of STING signaling plays an important role in anti-tumor immunity, and we previously reported the effects through accumulation M1-like macrophages tumor tissue treated with a agonist. However, myeloid cells express SIRPα, inhibitory receptor for phagocytosis, its receptor, CD47, is overexpressed various cancer types. Based on our findings that breast patients highly expressed CD47 have poor survival, evaluated therapeutic efficacy underlying mechanisms combination therapy ligand...
Placenta-specific 1 (PLAC1) is expressed primarily in placental trophoblasts but not normal tissues and a targetable candidate for cancer immunotherapy because it testis antigen known to be up-regulated various tumors. Although peptide epitopes capable of stimulating CD8 T cells have been previously described, there no reports PLAC1 CD4 helper lymphocyte (HTL) the expression this head neck squamous cell carcinoma (HNSCC). Here, we show that highly 74.5% oropharyngeal 51.9% oral cavity tumors...
The human T cell receptor is capable of distinguishing between normal and post-translationally modified peptides. Because aberrant phosphorylation cellular proteins a hallmark malignant transformation, the expression phosphorylated epitope could be an ideal antigen to combat cancer without damaging tissues. p53 activates transcription factors suppress tumors by upregulating growth arrest apoptosis-related genes. In response DNA damage, at multiple sites including Ser33 Ser37. Here, we...
Head and neck squamous cell carcinoma (HNSCC) originates from epithelium of the upper aerodigestive tract is most common malignancy in head region. Among HNSCCs, oropharynx (OSCC) has a unique profile associated with human papillomavirus infection. Recently, anti-programmed death-1 monoclonal antibody yielded good clinical responses recurrent and/or metastatic HNSCC patients. Therefore, programmed death-ligand 1 (PD-L1) may be favorable target molecule for cancer immunotherapy. Although...
Abstract Recent studies have revealed that tumor cells decrease their immunogenicity by epigenetically repressing the expression of highly immunogenic antigens to survive in immunocompetent hosts. We hypothesized these hidden “stealth” should be favorable targets for cancer immunotherapy due high immunogenicity. To identify stealth antigens, we treated human lung cell line A549 with DNA methyltransferase inhibitor 5‐aza‐2′‐deoxycytidine (5Aza) and its prodrug guadecitabine 3 d vitro screened...
Introduction Activation of T cell receptor (TCR) signaling is critical for clonal expansion CD8+ cells. However, the effects augmenting TCR during chronic antigen exposure less understood. Here, we investigated role diacylglycerol (DAG)-mediated downstream lymphocytic choriomeningitis virus clone 13 (LCMV CL13) infection by blocking DAG kinase zeta (DGKζ), a negative regulator DAG. Methods We examined activation, survival, expansion, and phenotype virus-specific in acute phases LCMV...
We report a rare case of granulomatosis with polyangiitis (GPA) presenting hypertrophic cranial pachymeningitis (HCP), abducens nerve palsy, and stenosis the internal carotid artery (ICA). A 59-year-old Japanese man presented year history nasal obstruction 2-month slight headache. Histopathological examination granulomatous mucosa in ethmoid sinuses resected by endoscopic sinus surgery revealed necrotizing vasculitis multinucleated giant cells. The patient was diagnosed limited form GPA as...
Metastasis from lung carcinoma to the sphenoid bone is rare. Patients with symptoms related metastasis as initial presentation of are thus also Herein, we report case a patient presenting only cheek dysesthesia first sign adenocarcinoma. The 74-year-old woman presented 2-month history left dysesthesia. CT showed tumor around 2.5 cm in diameter heterogeneous enhancement central focus at foramen rotundum bone. We endoscopically biopsied through sinus. Results histologic examination were...