A5039323915- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Ear and Head Tumors
- Tumors and Oncological Cases
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Elbow and Forearm Trauma Treatment
- Oral and Maxillofacial Pathology
- Orthopedic Surgery and Rehabilitation
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Stroke Rehabilitation and Recovery
- Orthopaedic implants and arthroplasty
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Brain Tumor Detection and Classification
- Pancreatic and Hepatic Oncology Research
- Viral-associated cancers and disorders
- Thyroid Cancer Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Speech and Audio Processing
- Ear Surgery and Otitis Media
- Neural Networks and Applications
- Total Knee Arthroplasty Outcomes
Tokushima Municipal Hospital
2019-2025
Japanese Red Cross Hokkaido College of Nursing
2022-2025
Asahikawa Medical University
2019-2024
Kyorin University
2020-2023
Yokohama National University
2023
Hokuto Hospital
2019-2022
Ritsumeikan University
2019-2022
Oita University
2022
Sendai City Hospital
2021
Red Cross Hospital
2021
ABSTRACT Background The efficacy of anti‐PD‐1 and EGFR therapies for head neck squamous cell carcinoma (HNSCC) can be predicted using various markers; however, the stability these markers remains unclear. Methods In this retrospective study, laboratory findings tissue expression PD‐L1, PD‐L2, were analyzed in 79 paired naive recurrent HNSCC tumors. Laboratory also nonrecurrent patients a propensity score‐matched analysis. PD‐L1 PD‐L2 levels assessed tumor proportion score (TPS) combined...
Abstract In CD70‐expressing tumors, the interaction of CD70 on tumor cells with its lymphocyte receptor, CD27, is thought to play a role in immunosuppression microenvironment and elevated serum levels soluble CD27 (sCD27). Previous studies showed that expressed nasopharyngeal carcinoma (NPC), an Epstein–Barr virus (EBV)‐related malignancy. However, association between intratumoral CD70/CD27 expression sCD27 NPC remains unclear. present study, we show primarily by CD27‐positive lymphocytes...
Abstract Background The identification of epitope peptides from tumor‐associated antigens (TAAs) is informative for developing tumor‐specific immunotherapy. However, only a few epitopes have been detected in mouse TAAs head and neck cancer (HNSCC). Methods Novel c‐Met‐derived T‐cell were predicted by computer‐based algorithms. Mouse HNSCC cell line‐bearing mice treated with c‐Met peptide vaccine. effects CD8 and/or CD4 depletion, vaccine combination immune checkpoint inhibitors (ICIs)...
Abstract Background We analyzed the effects of early nutritional intervention by a support team (NST) in patients with head and neck squamous cell carcinoma (HNSCC) undergoing chemoradiotherapy or radiotherapy. Methods This study investigated whether interventions multidisciplinary NST improve body weight loss, mucositis, serum albumin level, hospital length stay. Results Sixty‐one HNSCC were treated during study, 32 received since admission. The median loss rates 3.3% 7.3% grade 3 mucositis...
Abstract Background Predictive biomarkers for nivolumab in recurrent or metastatic head and neck squamous cell carcinoma (RMHNSCC) have not yet been established. Methods The tumor proportion score (TPS), combined positive (CPS), soluble forms of programmed death ligand‐1 (PD‐L1) ligand‐2 (PD‐L2) were retrospectively analyzed patients with RMHNSCC treated nivolumab. Results positivity rates TPS (PD‐L1), CPS (PD‐L2), 73.8%, 78.2%, 56.4%, respectively. Patients high (PD‐L1 PD‐L2) showed...
Fluorine 18-fluoro-glucose positron emission tomography/computed tomography (
Alzheimer’s disease (AD) is an irreversible progressive cerebral with most of its symptoms appearing after 60 years age. has been largely attributed to accumulation amyloid beta (Aβ), but a complete cure remained elusive. 18F-Florbetaben positron emission tomography (PET) shown as more powerful tool for understanding AD-related brain changes than magnetic resonance imaging and computed tomography. In this paper, we propose accurate classification method scoring plaque load (BAPL) based on...
A combination therapy with immune checkpoint inhibitors (ICIs) and platinum-based chemotherapy has become the first-line treatment for recurrent or metastatic head neck squamous carcinoma (HNSCC). Although steroids are often used as anti-emetic medications during chemotherapy, their adverse effects on immune-combined unclear in HNSCC.The of dexamethasone tumor growth cell population were evaluated a mouse HNSCC model treated PD-1 blockade combined cisplatin. The effect various doses...
Abstract Objective Immune checkpoint inhibitors (ICIs) have been considered as novel therapeutic approaches for various cancers. ICIs were reportedly efficacious against rare cancers, including salivary gland carcinoma (SGC). We aimed to analyze the efficacy and safety of in patients with SGC. Methods retrospectively analyzed oncologic outcomes immune‐related adverse events (irAEs) SGC treated at least one cycle nivolumab or pembrolizumab. Results Among 12 patients, there two a complete...
Aims Rotational acetabular osteotomy (RAO) is an effective joint-preserving surgical treatment for dysplasia. The purpose of this study was to investigate changes in muscle strength, gait speed, and clinical outcome the operated hip after RAO over a one-year period using standard protocol rehabilitation. Patients Methods A total 57 patients underwent Changes strength hip, 10 m Japanese Orthopaedic Association (JOA) score, factors correlated with were retrospectively analyzed. Results Three...
Abstract Homeobox B7 ( HOXB7 ) is a master regulatory gene that regulates cell proliferation and activates oncogenic pathways. Overexpression of correlates with aggressive behavior poor prognosis in patients cancer. However, the expression role head neck squamous carcinoma (HNSCC) remain unclear. In this study, we observed most samples from oropharyngeal cancer HNSCC expressed . As no direct inhibitor has been reported, identified potent peptide epitope to target ‐expressing tumors through...
<b><i>Introduction:</i></b> Due to the rarity and various histological types, a standard chemotherapy regimen for recurrent or metastatic salivary gland carcinoma (SGC) has not been established. Molecular-targeted therapy is novel cancer based on expression of target molecules. However, few molecular-targeted types have shown satisfactory efficacy patients with SGC. Our study described promising results epidermal growth factor receptor (EGFR)-targeting paclitaxel in...
Acute ischemic stroke (AIS) is a critical complication in patients undergoing dialysis. Although the improvement of AIS management an urgent requirement, few studies have evaluated prognostic factors these patients. This study aimed to assess relationship between clinical dialysis and prognosis AIS.Among 1267 who were hospitalized for Sendai City Hospital from January 2015 June 2020, 81 hemodialysis retrospectively enrolled. Multivariate analysis was performed evaluate effect baseline...
In this report we present a case of re-stabilization the proximal radius using vascularized free fibular graft combined with anconeus arthroplasty to stabilize transplanted fibula in patient large loss due Ewing’s sarcoma. A 20-year-old woman had sarcoma three-fourths radius. The resection part containing radial head were necessary for removal Reconstruction was performed and stabilized by attaching edge fibula. 2 years after surgery, she neither recurrence nor metastasis, achieved...
<b><i>Introduction:</i></b> Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory characterized by elevated serum IgG4, tissue infiltration of IgG4-positive cells, and fibrosis. Although number IgG4-RD patients show sinonasal involvement, there little known about inflammation associated with IgG4-RD. This study aimed to describe the clinicopathological features compare other diseases, such as eosinophilic chronic rhinosinusitis (ECRS) granulomatosis...
Endoscopic ultrasound (EUS)-guided transluminal drainage has become a first-line treatment modality for symptomatic pancreatic pseudocysts. Despite the increasing popularity of lumen-apposing metal stents (LAMSs), plastic may resolve non-necrotic fluid collections effectively with lower costs and no LAMS-specific adverse events. To date, there been paucity data on appropriate stent type in this setting. This trial aims to assess non-inferiority LAMS initial EUS-guided The WONDER-02 is...
Intratumoral hypoxia is associated with tumor progression, aggressiveness, and therapeutic resistance in several cancers. Hypoxia causes cancer cells to experience replication stress, thereby activating DNA damage repair pathways. MutT homologue-1 (MTH1, also known as NUDT1), a member of the Nudix family, maintains genomic integrity viability hypoxic microenvironment. Although poor prognosis can cause by regulating microenvironment, it has not been considered treatable target cancer. This...