A5085278426- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Metabolism, Diabetes, and Cancer
- Inflammatory Biomarkers in Disease Prognosis
- Oral and gingival health research
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Biliary and Gastrointestinal Fistulas
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Foreign Body Medical Cases
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- IgG4-Related and Inflammatory Diseases
Kagawa University
2016-2025
Kin-ikyo Chuo Hospital
1995-2017
Okayama Prefecture
2015
The University of Tokyo
2014
Kagawa University Hospital
1972-2012
JR Tokyo General Hospital
2011-2012
Gifu University Hospital
2011-2012
Nagano Municipal Hospital
2012
Gifu Municipal Hospital
2012
Onomichi General Hospital
2012
Endoscopic ultrasound-guided biliary drainage (EUS-BD) can be carried out by two different approaches: choledochoduodenostomy (CDS) and hepaticogastrostomy (HGS). We compared the efficacy safety of these approaches in malignant distal obstruction (MDBO) patients using a prospective, randomized clinical trial.Patients with after failed endoscopic retrograde cholangiopancreatography were randomly selected for either CDS or HGS. The procedures at nine tertiary centers from September 2013 to...
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is used for the histopathological diagnosis of any type gastrointestinal disease. Few adverse events are experienced with this procedure; however, actual rate remains unclear. This study aimed to clarify current status cases that related EUS-FNA procedure histopathologic diagnoses.A retrospective analysis EUS-FNA-related in Japanese tertiary centers was conducted by assessing following clinical data: basic case information, FNA...
Unresectable malignant bile duct stricture (often caused by unresectable pancreatic cancer and cholangiocarcinoma) can be drained via insertion of self-expandable metal stents (SEMS) during endoscopic retrograde cholangiopancreatography (ERCP). Because recurrent biliary obstruction (RBO) complications following stent delay chemotherapy other treatments, a longer time to RBO (TRBO) is desirable. Although TRBO has been reported among patients who undergo with larger diameter SEMS, smaller...
Carcinoma of the ampulla Vater is uncommon. This study aimed to clarify predictors survival for ampullary adenocarcinoma and identify characteristics its two major pathological subtypes.Medical records were reviewed 86 patients who underwent curative resection between 2000 2012 at 12 principal hospitals in Kagawa, Japan.Resection was most common among 75-79-year-old patients. Actuarial 1-, 3-, 5-year postoperative rates 90%, 72.3%, 69.1%, respectively. Preoperative biliary drainage; serum...
Abstract Background With the increasing popularity of endoscopic ultrasound (EUS)-guided transmural interventions, walled-off necrosis (WON) pancreas is increasingly managed via non-surgical interventions. However, there has been an ongoing debate over appropriate treatment strategy following initial EUS-guided drainage. Direct necrosectomy (DEN) removes intracavity necrotic tissue, potentially facilitating early resolution WON, but may associate with a high rate adverse events. Given safety...
Hepatitis B virus (HBV)-related hepatocarcinogenesis is not necessarily associated with the liver fibrotic stage and occasionally seen at early stages. MicroRNAs (miRNAs) are essentially 18- to 22-nucleotide-long endogenous noncoding RNAs. Aberrant miRNA expression a common feature of various human cancers. The aberrant specific miRNAs has been shown in hepatocellular carcinoma (HCC) tissue compared nontumor tissue. Thus, we examined targetable as potential new biomarker related high risk...
Objective Stenting is an established endoscopic therapy for malignant gastric outlet obstruction (mGOO). The choice of stent (covered vs uncovered) has been examined in prior randomised studies without clear results. Design In a multicentre prospective study, we compared covered (CSEMS) with uncovered self-expandable metal stents (UCSEMS) patients mGOO; main outcomes were dysfunction and patient survival, subgroup analyses extrinsic intrinsic tumours. Results Overall survival was poor no...
Abstract Background The perioperative factors predicting or influencing early pancreatic ductal adenocarcinoma recurrence are unclear. This study attempted to identify the predictive for post-pancreatectomy and influence of pre- post- operative adjuvant therapy. Methods One hundred fifteen patients undergoing curative resection between 2000 2016 at our institution were retrospectively analyzed. Patients divided into two groups: those who did ( n = 34) not 81) experience a within 6 months...
: The efficacy of neoadjuvant chemoradiotherapy (NACRT) followed by pancreatoduodenectomy (PD) in elderly patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear.
We review the utility of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), a rapid, safe, cost-effective, and accurate diagnostic modality for evaluating pancreatic tumors. EUS-FNA is currently used diagnosis staging The sensitivity malignancy ranges from 75% to 94%, its specificity approaches 100% in most studies. However, has some limitations well-differentiated or early-stage cancers. Recent evidence suggests that molecular biological analysis using specimens obtained by...
Abstract Background and study aims Endoscopic ultrasound-guided fine needle aspiration (FNA) for gastrointestinal subepithelial lesions (SELs) has limited diagnostic accuracy due to technical problems small lesion size. We previously reported a novel submucosal tunneling biopsy (STB) technique sampling SELs. This aimed evaluate the ability safety of STB compared that FNA Patients methods The was non-randomized, prospective comparative with crossover design in patients endoluminal gastric...
Although gemcitabine (2',2'-difluorocytidine monohydrochloride) is a common anticancer agent of cholangiocellular carcinoma (CCC), its growth inhibitory effects and resistance in CCC cells are poorly understood. Our aims were to uncover the mechanism underlying antitumor effect analyze regulating vitro cell resistance. In addition, we sought identify miRNAs associated with CCCs. Using proliferation assay flow cytometry, examined ability inhibit three types human lines (HuCCT-1, Huh28, TKKK)....
Gallbladder cancer is the most common biliary tract with poor prognosis and wide variation in incidence rates worldwide, being very high some countries Latin America Asia. Treatment of type 2 diabetes metformin causes a reduction cancer. Till date, there are no reports on anti-tumor effects gall bladder Therefore, this study evaluated proliferation human gallbladder adenocarcinoma cells vitro vivo, as well explored microRNAs associated metformin. Metformin inhibited cell lines NOZ,...