A5050163685- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Biliary and Gastrointestinal Fistulas
- Esophageal Cancer Research and Treatment
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Drug-Induced Adverse Reactions
- Inflammatory mediators and NSAID effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Appendicitis Diagnosis and Management
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
Himeji Medical Center
2022-2024
Tokyo-Kita Medical Center
2015-2023
Nippon Steel Yawata Memorial Hospital
2021
Kobe University
2010-2013
Komaki City Hospital
2013
Ministry of Education, Culture, Sports, Science and Technology
2010
Kobe University Hospital
2008-2009
The Cancer Institute Hospital
2005
The requirements of biliary stents used in the palliation malignant obstruction are a long duration patency and minimal adverse effects. Covered self-expandable metal (SEMSs) have been shown to prevent tumor ingrowth, which is most frequent complication uncovered SEMSs. However, because they prone migration, superiority covered SEMS has yet be convincingly demonstrated. aim this study was evaluate over SEMSs distal due unresectable pancreatic carcinoma, using both stent types with relatively...
Background and study aims: Laterally spreading tumors – non granular type (LST-NG) are more often considered candidates for endoscopic submucosal dissection (ESD) than laterally (LST-G), because of their higher potential invasion. However, ESD LST-NG can be technically difficult. The aim our was to compare results LST-G.
Endoscopic submucosal dissection (ESD) using short needle knives is safe and effective, but bleeding a problem due to low haemostatic capability.To assess the performance of novel ball-tipped knife (Flush knife-BT) for ESD with particular emphasis on haemostasis.A case-control study compare 30 pairs consecutive early gastrointestinal lesions (oesophagus: 12, stomach: 32, colorectum: 16) standard Flush (F) vs. knife-BT (BT). Primary outcome was efficacy intraprocedure haemostasis. Secondary...
Introduction: Early stage colorectal tumors can be removed by endoscopic mucosal resection (EMR) but larger (≧20 mm) may require piecemeal resection. The development of submucosal dissection (ESD) has enabled en‐bloc lesions regardless size and shape. However ESD tumor is technically difficult. As the resources, we perform EMR with small incision (EMR SI) for more reliable EMR, also snaring (simplified ESD) easier safer ESD. Aim & Methods: aim study was to retrospectively compare...
Goals The predictors of malignant intraductal papillary mucinous neoplasm (IPMN) and invasive IPMN were investigated in this study to determine the optimal indicators surgical resection for IPMN. Background Recently, international consensus guidelines have described standard However, IPMN, especially branch duct still remain controversial. Study Eighty-two patients with who underwent during April 1998 January 2009, retrospectively reviewed examined regard their preoperative factors...
Focal parenchymal atrophy and main pancreatic duct (MPD) dilatation have been identified as early signs of ductal adenocarcinoma. However, limited evidence exists regarding their temporal progression due to previous study limitations with restricted case numbers.
Abstract Background Continuous regional arterial infusion (CRAI) of protease inhibitor nafamostat mesilate (NM) is used in the context predicted severe acute pancreatitis (SAP) to prevent development pancreatic necrosis. Although this therapy well known Japan, its efficacy and safety remain unclear. Methods This investigator-initiated -driven, multicenter, open-label, randomized, controlled trial (UMIN000020868) enrolled 39 patients with SAP low enhancement parenchyma on computed tomography...
BACKGROUND: Early stage colorectal tumors can be removed by endoscopic mucosal resection but larger such (>20mm) may require piecemeal resection. Endoscopic submucosal dissection (ESD) using newly developed endoknives has enabled en-block of lesions regardless size and shape. However ESD for tumor is technically difficult. Therefore, we performed EMR with small incision (EMR SI) more reliable EMR, snaring (simplified ESD) thestandard Flush knife the novel ball tipped (Flush BT) easier...
Objective Stenting is an established endoscopic therapy for malignant gastric outlet obstruction (mGOO). The choice of stent (covered vs uncovered) has been examined in prior randomised studies without clear results. Design In a multicentre prospective study, we compared covered (CSEMS) with uncovered self-expandable metal stents (UCSEMS) patients mGOO; main outcomes were dysfunction and patient survival, subgroup analyses extrinsic intrinsic tumours. Results Overall survival was poor no...
In the colorectal tumor, lesions suitable for endoscopic treatment are those with no lymph node metastasis such as adenomas, intramucosal cancers, and minimally invasive submucosal cancer (invasion depth 1000 m, well moderately differentiated type, lymphovascular invasion). The new endOscopic technique, dissection (ESD) enables en-bloc resection of regardless their size location. order to perform ESD more easily, safely, efficiently, we invented water jet short needle knives (Flush knife)....
The discovery of novel and effective treatment methods would be great help to patients with acute pancreatitis. aims this study were determine the inhibitory effects vitamin K3 (VK3) against cerulein-induced pancreatitis in mice examine mechanisms behind these effects.Acute was induced by intraperitoneal injection cerulein 6 times at hourly intervals. Vitamin administered once before first or twice after cerulein. degrees inflammation autophagy pancreatic tissue estimated histological...
Apolipoprotein A2-ATQ/AT (apoA2-ATQ/AT) has been identified as a minimally invasive biomarker for detecting pancreatic cancer (PC) and high-risk (HR) individuals PC. To establish an efficient enrichment strategy HR, we carried out plasma apoA2-ATQ/AT level-based prospective screening study among the general population. The subjects were recruited at six medical check-up facilities in Japan between October 2015 January 2017. We evaluated positive predictive value (PPV) of level ≤35 μg/mL PC...
Abstract Background Conducting randomized controlled trial ( RCT ) for each of the risk factors associated with prophylactic pancreatic duct stent PPDS post‐endoscopic retrograde cholangiopancreatography ERCP) pancreatitis PEP is difficult owing to volume cases and ethical considerations. In this study, we tried reveal degree preventive effects individual factor within high‐risk group using propensity score analysis. Methods The clinical data 1131 ERCP practices performed at K obe U...
Background We aimed to clarify the factors associated with presentation of erosive esophagitis (EE) symptoms in subjects undergoing health checkups. Methods utilized baseline data from 7,552 who underwent upper endoscopy for screening a prospective, multicenter cohort study. The were asked complete questionnaire detailing their abdominal and lifestyle. Based on heartburn and/or acid regurgitation frequency, EE stratified into following three groups: (1) at least one day week (symptomatic...
Background: Narrow band imaging (NBI) with magnifying endoscopy (NBI‐ME) allows the detection of abnormal micro‐lesions smaller than 5 mm in diameter oro‐hypopharynx that could not be visualized previously. The purpose present study was to clarify clinicopathological characteristics detected by NBI‐ME Methods: Of 62 lesions NBI‐ME, 40 37 patients were removed endoscopic treatment and pathologically evaluated. We reviewed medical records these investigated relationship between findings...
Our objective is to elucidate the usefulness of maspin/p53 double immunostaining on biliary brushing cytology specimens. We first examined expression maspin in epithelium with variable degrees dysplasia using surgically resected specimens (n = 56). Maspin appeared be overexpressed a stepwise manner from benign malignant cholangiocytes: reactive (20%), intraepithelial neoplasia (~50%), and invasive cholangiocarcinomas (>90%). Next, an automated sequential protocol for p53 was applied...