A5051481629- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Inflammatory mediators and NSAID effects
- Metastasis and carcinoma case studies
- Inflammatory Bowel Disease
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Diverticular Disease and Complications
- Pediatric Hepatobiliary Diseases and Treatments
- IL-33, ST2, and ILC Pathways
- Organ Transplantation Techniques and Outcomes
- Olfactory and Sensory Function Studies
- Pancreatitis Pathology and Treatment
- Veterinary medicine and infectious diseases
Osaka Metropolitan University
2022-2023
Tokyo Metropolitan University
2022-2023
Osaka City University
2013-2022
Osaka University
2018
National Institute of Diabetes and Digestive and Kidney Diseases
2018
ProQuest (United States)
2018
Osaka City General Hospital
2009-2012
Osaka Medical and Pharmaceutical University
2008
Kurashiki Medical Center
2002
Kobe University
1998
The requirements of biliary stents used in the palliation malignant obstruction are a long duration patency and minimal adverse effects. Covered self-expandable metal (SEMSs) have been shown to prevent tumor ingrowth, which is most frequent complication uncovered SEMSs. However, because they prone migration, superiority covered SEMS has yet be convincingly demonstrated. aim this study was evaluate over SEMSs distal due unresectable pancreatic carcinoma, using both stent types with relatively...
Abstract Objective: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and irritable bowel syndrome (IBS) are common, have negative impacts on health‐related quality of life (HR‐QOL). Several studies demonstrated a significant overlap between two these three diseases. The purpose this study was to examine the prevalence GERD, FD, IBS, their rates, HR‐QOL for each compared with healthy controls in Japanese general population. Methods: We performed cross‐sectional workers who...
Background: Enterobacteria and cytokines both play roles in the pathophysiology of NSAID-induced enteropathy. Toll-like receptor (TLR) 4 recognises lipopolysaccharide (LPS), resulting activation an inflammatory cascade via accessory protein MyD88. Aims: To investigate role TLR4 responses indomethacin-induced Methods: Indomethacin was administered p.o. to non-fasting rats mice induce small intestinal damage. The extent such damage evaluated by measuring injured area stained dark blue with...
The usefulness of non-magnifying endoscopy with narrow-band imaging (NBI; NM-NBI) in the screening early esophageal squamous cell carcinoma (SCC) and high-grade intraepithelial neoplasia (HGIN) remains unclear. Here, we aimed to compare NM-NBI chromoendoscopy iodine staining (CE-Iodine) terms diagnostic performance, evaluate detecting SCC.We prospectively enrolled 202 consecutive patients (male/female=180/22; median age, 67 years) high-risk factors for SCC. All received endoscopic...
Abstract The inflammasomes induce maturation of pro-interleukin-1β (IL-1β) and pro-IL-18. We investigated roles the NLRP3 inflammasome in pathogenesis ulcerative colitis (UC). After induction oxazolone-induced colitis, a mouse UC model, colonic tissues were assayed for inflammatory mediators. Histological studies performed on inflamed tissue from mice patients. severity murine peaked day 1, accompanied by an increase expression Th2 cytokines including IL-4 IL-13. Oxazolone treatment...
Chest radiography is a common and widely available examination. Although cardiovascular structures-such as cardiac shadows vessels-are visible on chest radiographs, the ability of these radiographs to estimate function valvular disease poorly understood. Using datasets from multiple institutions, we aimed develop validate deep-learning model simultaneously detect functions radiographs.
OBJECTIVES It is generally recommended that patients with gastro-esophageal reflux disease (GERD) refrain from eating within 3 h of going to sleep. In addition a remarkable lack supporting clinical evidence, whether GERD have shorter dinner-to-bed time unknown. This study was designed determine possible association between and GERD, compared healthy adults. METHODS matched case-control study, we enrolled 147 patients, age- sex-matched 294 controls without symptoms such as heartburn acid...
Background and aimsAppropriate influenza vaccination is important for patients with inflammatory bowel disease under immunosuppressive therapy. The purpose of this study was to evaluate the influence therapy on immune response trivalent vaccine in adult disease.
Abstract Background and Aim: Epidemiological studies have shown that 10–48% of people in developed countries gastroesophageal reflux disease (GERD) symptoms such as heartburn acid regurgitation. The present study aimed to examine the prevalence GERD Japanese subjects. Methods: A cross‐sectional subjects who visited a clinic for routine health check up was carried out. Subjects were asked fill out self‐report questionnaire. defined presence and/or regurgitation at least twice per week....
Helicobacter pylori infection and atrophic gastritis are inversely related to erosive esophagitis. Whether these factors affect the pathogenesis of endoscopy-negative reflux disease is not clear. We aimed elucidate differences in clinical characteristics between esophagitis.253 subjects (89 with 164 esophagitis) were studied. Gastric atrophy was assessed by measurement serum pepsinogen. Logistic regression used calculate odds ratio (OR) 95% confidence intervals (CI) compared...
Objectives Neutrophil-to-lymphocyte ratio (NLR) has been used to determine the outcome in malignancies and coronary heart disease. Some reports considered value of NLR as a predictor response infliximab patients with Crohn's disease or rheumatoid arthritis; however, no similar studies have reported for ulcerative colitis (UC). This study aimed evaluate clinical significance baseline UC treated by infliximab. Materials Methods Patients moderate-to-severe active who received first infusion our...
The inflammasome is a large, multiprotein complex that consists of nucleotide-binding oligomerization domain-like receptor (NLR), an apoptosis-associated speck-like protein containing caspase recruitment domain, and pro-caspase-1. Activation the results in cleavage pro-caspase-1 into cleaved caspase-1, which promotes processing pro-interleukin (IL)-1β mature IL-1β. We investigated effects colchicine on non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury activation...
Objective Smoking is associated with gastroesophageal reflux disease (GERD). Varenicline, a nicotinic receptor partial agonist, used to aid smoking cessation. The purpose of this study was prospectively examine the long-term benefits cessation on GERD and health-related quality life (HR-QOL). Methods Patients treated varenicline were asked fill out self-report questionnaire about their habits, gastrointestinal symptoms, HR-QOL before 1 year after prevalence GERD, frequency scores compared....
Objectives The objective of this study was to develop and validate a state-of-the-art, deep learning (DL)-based model for detecting breast cancers on mammography. Methods Mammograms in hospital development dataset, test clinic dataset were retrospectively collected from January 2006 through December 2017 Osaka City University Hospital Medcity21 Clinic. publicly available digital database screening mammography (DDSM) used train the RetinaNet, one type DL-based model, with five-fold...
We aimed to develop the deep learning (DL) predictive model for postoperative early recurrence (within 2 years) of hepatocellular carcinoma (HCC) based on contrast-enhanced computed tomography (CECT) imaging. This study included 543 patients who underwent initial hepatectomy HCC and were randomly classified into training, validation, test datasets at a ratio 8:1:1. Several clinical variables arterial CECT images used create models recurrence. Artificial intelligence implemented using...
Irritable bowel syndrome (IBS) is a common gastrointestinal disease. Detailed clinical characteristics of patients with different IBS subtypes have not been well established. Our aim was to examine the prevalence and risk factors its in Japanese adults.We performed cross-sectional study workers who visited clinic for routine health check-up asked them fill out self-report questionnaire. were defined by ROME III criteria. A logistic regression model used identify factors.Irritable present 367...
Background Low-dose aspirin (LDA) frequently causes small bowel injury. While some drugs have been reported to be effective in treating LDA-induced intestinal damage, most studies did not exclude patients with mild damage thought clinically insignificant. Aim We conducted a multicenter, randomized, double-blind, placebo-controlled trial assess the efficacy of high dose rebamipide, gastroprotective drug, for moderate-to-severe enteropathy. Methods enrolled who received 100 mg enteric-coated...