A5103498560- Mesenchymal stem cell research
- Acute Ischemic Stroke Management
- Diamond and Carbon-based Materials Research
- Mitochondrial Function and Pathology
- Cardiovascular Health and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Heat Transfer Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Pulmonary Hypertension Research and Treatments
- Vascular Anomalies and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Pleural and Pulmonary Diseases
- Peripheral Nerve Disorders
- Spinal Fractures and Fixation Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Plasma and Flow Control in Aerodynamics
- Spine and Intervertebral Disc Pathology
- Spinal Hematomas and Complications
Massachusetts General Hospital
2024-2025
Harvard University
2024-2025
Sapporo Medical University
2016-2024
Tokyo Medical University Hospital
2021-2023
Kagoshima University
2014-2023
Tokyo Medical University
2023
Jikei University School of Medicine
2017-2022
Tsurugi Hospital
2020-2021
City Hospital
2018-2020
Sasaki Institute
2017-2020
The requirements of biliary stents used in the palliation malignant obstruction are a long duration patency and minimal adverse effects. Covered self-expandable metal (SEMSs) have been shown to prevent tumor ingrowth, which is most frequent complication uncovered SEMSs. However, because they prone migration, superiority covered SEMS has yet be convincingly demonstrated. aim this study was evaluate over SEMSs distal due unresectable pancreatic carcinoma, using both stent types with relatively...
Although spinal cord injury (SCI) is a major cause of disability, current therapeutic options remain limited. Recent progress in cellular therapy with mesenchymal stem cells (MSCs) has provided improved function animal models SCI. We investigated the safety and feasibility intravenous infusion MSCs for SCI patients assessed functional status after MSC infusion. In this phase 2 study autologous cultured auto-serum, single under Good Manufacturing Practice (GMP) production was delivered 13...
Menopause causes arterial senescence and atherosclerotic development through decrease of estrogen. Recently, histone deacetylase SIRT1 has been reported to have protective effects against atherosclerosis. However, the relationship between estrogen in context menopause-induced is not well understood. The present study aims investigate whether involved etiology development.Twelve-week old female apolipoprotein E-knockout (ApoE-KO) mice underwent ovariectomy (OVX) or sham surgery.SIRT1...
Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat stroke models. Rehabilitation therapy through physical exercise also provides therapeutic efficacy for cerebral ischemia.The purpose this study was to investigate whether synergic effects daily rehabilitation and intravenous MSCs has after rats.This an experimental study.A permanent middle artery occlusion (MCAO) induced by intraluminal vascular with a microfilament. Four...
OBJECTIVE Reperfusion therapy with intravenous recombinant tissue plasminogen activator (rtPA) is the standard of care for acute ischemic stroke. However, hemorrhagic complications can result. Intravenous infusion mesenchymal stem cells (MSCs) reduces stroke volume and improves behavioral function in experimental models. One suggested therapeutic mechanism inhibition vascular endothelial dysfunction. The objective this study was to determine whether MSCs suppress events after rtPA phase...
Rho-associated protein kinase (ROCK) inhibitors are therapeutic candidates in ischemic stroke and subarachnoid hemorrhage. However, their efficacy intracerebral hemorrhage (ICH) is unknown. Here, we tested the of fasudil (10 mg/kg), an isoform-nonselective ROCK inhibitor, NRL-1049 a novel inhibitor with 43-fold higher selectivity for ROCK2 isoform compared ROCK1, collagenase-induced ICH model mice. Both short (1–3 days) prolonged (14 paradigms were using robust sample sizes both males...
Background: Calcitonin gene-related peptide (CGRP) is a potent vasodilator that plays role in migraine. Monoclonal antibodies targeting CGRP, such as fremanezumab, now widely used for migraine prevention. However, inhibition of CGRP system may also lead to vasoconstriction, raising concerns about whether the long-term treatment with these patients might increase risk stroke or worsen outcomes if occurs while taking medications. Here, we aimed investigate fremanezumab exacerbates mouse model...
Collateral development plays an important role in maintaining cerebral blood flow (CBF) the presence of critical stenosis or occlusion large arteries. Age is a non-modifiable risk factor for ischemic stroke associated with collateral rarefaction. Here, we studied influence aging on and hemodynamic impairment using 114 mice (56 male 58 female, C57/BL6) two age groups (young: 20 ± 2 weeks; aged: 71 9 weeks). We permanently occluded right common carotid artery (RCCAO) via suture ligation...
Background Ischemic stroke is among the most prevalent diseases, with high death and morbidity. Numerous preclinical studies have reported efficacious interventions in rodent models. However, reperfusion therapies remain only clinically intervention to date. Rigor reproducibility are now recognized as critical bridge preclinical–clinical disconnect. Inter‐α inhibitor proteins (IαIPs) a family of structurally related glycoproteins 2 major forms (inter‐α pre‐α inhibitor) blood. Purified human...
Background The risk of cardiovascular disease is known to increase after menopause. Mitochondria, which undergo quality control via mitochondrial autophagy, play a crucial role in the regulation cellular senescence. aim this study was investigate whether effect estrogen‐mediated protection from senescence on arteries attributed induction autophagy. Methods and Results We used human umbilical vein cells, vascular smooth muscle 12‐week‐old female C57BL/6 mice. administration 17β‐estradiol (E2)...
BackgroundPulmonary endarterectomy (PEA) is the standard treatment for chronic thromboembolic pulmonary hypertension (CTEPH), although some patients may experience residual (PH). It unclear whether balloon angioplasty (BPA) effective PH after PEA. This study aimed to compare BPA outcomes between with PEA and those inoperable CTEPH.MethodsThis retrospective compared (25 patients, 101 sessions) alone CTEPH (21 89 sessions). All underwent right heart catheterisation functional laboratory tests...
Monodispersive FePt nanoparticle films can be stabilized firmly on rigid Si substrates using amino-functional silane, such as [3-(2-aminoethlyamino) propyl]trimethoxysilane, a coupling layer. The substrate/SiO2/APTS/FePt nanoparticles heterostructure was confirmed high-resolution electron microscopy (HREM). HREM result agreed well with the x-ray reflectivity measurement upon individual layer thickness. as-made superparamagnetic film transformed from chemically disordered fcc structure to...
An effective method of employing 3-aminopropyldimethylethoxysilane linker molecules to stabilize 4.4 nm FePt nanoparticle monolayer films on a SiO2 substrate as well prevent coalescence the particles under 800 degrees C annealing is reported. As-deposited in chemically disordered face-centered-cubic phase transform mostly ordered L1 0 structure after annealing, while nanoparticles are free from serious coalescence. The may fulfill pressing need high-temperature for development based...
A 93% high-yield synthesis of well-dispersed, colorless zirconium dioxide (ZrO(2)) nanocrystals is reported. In this synthesis, hydrolysis and condensation reactions zirconium(IV) tert-butoxide in the presence oleic acid (100 degrees C) formed ZrO(2) precursors. The precursors were made -Zr-O-Zr- networks surrounded by molecules. Annealing (280 dispersed dioctyl ether caused crystallization networks, thereby generating 4 nm stabilized with acid. particles highly crystalline tetragonal phase....
Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat models cerebral infarction. Although clinical studies are ongoing, most have focused on the acute or subacute phase stroke. In present study, MSCs rats were intravenously infused 8 weeks after induction a middle artery occlusion (MCAO) to investigate whether delayed systemic injection functional outcome chronic stroke rats.
Abstract In order to assess the applicability of using microelectrodes as a tool for inhibition tests, temporal and spatial inhibitory effects 2‐chlorophenol (2‐CP) on O 2 respiration nitrification activities in municipal wastewater biofilms were investigated NH . The time‐course microelectrode measurements demonstrated that 2‐CP inhibited within 6–18 min. microbial only upper 400 μm by 2‐CP, bacteria present deeper parts still active, probably due limited penetration 2‐CP. These results...
Morbidity and mortality in patients with posterior circulation stroke remains an issue despite advances acute therapies. The intravenous infusion of mesenchymal stem cells (MSCs) elicits therapeutic efficacy experimental supratentorial models. However, since there are few reliable animal models ischemia the circulation, approach MSC has not been tested. objective this study was to test hypothesis that intravenously infused MSCs provide functional recovery a newly developed model brainstem...
Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow elicits functional recovery in rat stroke models and clinical studies patients are ongoing. Brain neurotrophic factor (BDNF) is a produced by MSCs may contribute to their therapeutic efficacy. The purpose the current study was determine if BDNF elevated infarcted brain which compartment blood (plasma or serum) after intravenous MSC middle cerebral artery occlusion (MCAO) model rat.In rats, permanent induced...
Our goal was to evaluate the combined effects of balloon pulmonary angioplasty (BPA) followed by endarterectomy (PEA) treat high-surgical-risk patients with chronic thromboembolic hypertension (CTEPH).This study included 58 CTEPH who had vascular resistance ≥1000 dyn·s/cm5, mean arterial pressure (mPAP) ≥45 mmHg or mPAP 38-44 comorbidities. Of these, 21 underwent therapy BPA PEA (BPA group) and 37 direct (non-BPA group). Preoperative postoperative results were compared between 2 groups. An...
The safety, feasibility, and potential functional improvement following the intravenous infusion of mesenchymal stem cells (MSCs) were investigated in patients with chronic severe spinal cord injury (SCI).