A5068543524- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Mesenchymal stem cell research
- Traumatic Brain Injury Research
- Stroke Rehabilitation and Recovery
- Head and Neck Surgical Oncology
- Venous Thromboembolism Diagnosis and Management
- Nitric Oxide and Endothelin Effects
- Anesthesia and Sedative Agents
- Pulmonary Hypertension Research and Treatments
- Pituitary Gland Disorders and Treatments
- Vasculitis and related conditions
- S100 Proteins and Annexins
- Ultrasound in Clinical Applications
- Advanced Neuroimaging Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Surgical Simulation and Training
- Teratomas and Epidermoid Cysts
- Retinal and Optic Conditions
- Meningioma and schwannoma management
- Genetics and Neurodevelopmental Disorders
- Protein Degradation and Inhibitors
- Vascular Malformations and Hemangiomas
Sapporo Medical University
2021-2024
Kochi Medical School Hospital
2014-2024
Kōchi University
2013-2021
University of Kochi
2019-2020
Sapporo Medical University Hospital
2020
CHI Health
2018-2019
Kokura Memorial Hospital
2019
Fujita Health University
2019
Osaka University
2010
Kindai University
2005
Transcriptional regulation of gene expression is thought to play a pivotal role in activity-dependent neuronal differentiation and circuit formation. Here, we investigated the histone deacetylase 9 (HDAC9), which regulates transcription by modification, development neocortical neurons. The translocation HDAC9 from nucleus cytoplasm was induced an increase spontaneous firing activity cultured mouse cortical This nucleocytoplasmic also observed postnatal vivo. translocation-induced cellular...
The purpose of this study was to investigate whether patients with low preoperative Diffusion-weighted Imaging Alberta Stroke Program Early Computed Tomography Score (DWI-ASPECTS) could benefit from mechanical thrombectomy for acute anterior circulation occlusion. This a retrospective, non-blinded, cohort study. From September 2012 August 2016, 83 consecutive occlusion were treated using second-generation devices or medical management. DWI-ASPECTS scored after the first MRI. Patient...
To identify a proximal anterior circulation occlusion for effectively administering immediate mechanical thrombectomy by developing novel, simple diagnostic scale to predict the occlusion, compare its validity with available scales, and assess utility.
Stroke is a major cause of long-term disability, and there are few effective treatments that improve function in patients during the chronic phase stroke. Previous research has shown single systemic infusion mesenchymal stem cells (MSCs) improves motor acute cerebral ischemia models rats. A possible mechanism could explain such an event includes enhanced neural connections between hemispheres contribute to therapeutic effects. In present study, repeated infusions (3 times at weekly...
The safety, feasibility, and potential functional improvement following the intravenous infusion of mesenchymal stem cells (MSCs) were investigated in patients with chronic severe spinal cord injury (SCI).
Cancer stem cells (CSCs) are the sole population possessing high self-renewal activity in tumors, with their existence affecting tumor recurrence. However, invasive of CSCs has yet to be fully understood. In this article, we established a sphere culture RSV-M mouse glioma (RSV-M-TS) and evaluated migration invasion activities. Histological analysis formed by cranial injection RSV-M-TS showed highly properties similarities human malignant tissues. When both were compared intracranial...
We describe a modification of the combined transseptal/transnasal binostril approach using two-surgeon, four-handed technique (modified Stamm’s approach) for pituitary lesions in patients with narrow nasal spaces. This comprises transseptal route through one nostril and transnasal without harvesting pedicled nasoseptal flap (NSF) other. On side, septum was removed an endoscopic septoplasty technique. mucosa containing septal branch sphenopalatine artery over face sphenoid preserved NSF if...
The purple-flesh potato (Solanum tuberosum L.) cultivar "Shadow Queen" (SQ) naturally contains anthocyanins. This randomized, double-blind, placebo-controlled study determines whether ingesting purple potatoes increases the number of mesenchymal stem cells (MSC) and improves stress response, a minor health complaint in healthy adults (registration number: UMIN000038876). A total 15 subjects (ages: 50-70 years) with complaints were randomly assigned to one two groups. For 8 weeks, placebo...
The diagnosis of CSF hypovolemia remains controversial. primary diagnostic factor relies on confirmation leakage the based reduced spinal fluid pressure. Determining specific site is most important issue for effective treatment but a difficult task. Although CT myelography, radioisotope cisternography, and MRI are commonly performed in hypovolemia, these techniques can rarely identify precise site. Therefore, an epidural blood patch lumbar spine many cases. This study reports new modality...
Brain injuries resulting from motor vehicle accidents and falls, as well hypoxic insults other conditions, are one of the leading causes disability death in world. Current treatments limited but include continuous rehabilitation, especially for chronic brain injury. Recent studies have demonstrated that intravenous infusion mesenchymal stem cells (MSCs) has therapeutic efficacy several neurological diseases, including stroke spinal cord injury.The objective our investigator-initiated...
This study explores safety, feasibility, and potential improvement in functional status after intravenous infusion of mesenchymal stem cells (MSCs) chronic severe brain injury (BI) patients. An autologous MSCs autoserum cultured under Good Manufacturing Practice was delivered to four patients with BI. In addition assessing feasibility neurological function evaluated using the National Institutes Health Stroke Scale, Fugl-Meyer Assessment, Barthel Index, cognitive-related behavioral...
We report two cases of acute proximal anterior circulation occlusion after pulmonary lobectomy.Case 1 was a 64-year-old male who presented with the right middle cerebral artery (MCA) one day left lower lobectomy. Case 2 68-year-old internal carotid (ICA). In both cases, mechanical thrombectomy performed for complete recanalization and symptoms were improved.Prompt in phase lobectomy improved prognosis patients occlusion. It is important to share information about ischemic complications...
要旨：感染性心内膜炎から外側後脈絡叢動脈領域の脳塞栓症を来し，感染性脳動脈瘤を形成した稀な症例を経験したので報告する．症例は44 歳，女性．倦怠感を自覚し近医受診，血液検査にて炎症反応高値であった．その後他院を受診し，軽度左不全麻痺を指摘．MRI にて，右側の海馬，側頭葉内側，視床，外側膝状体，尾状核体部にかけて病変を認め，当科紹介となった．心エコー検査で僧帽弁に疣贅を認めたため感染性心内膜炎と診断．3DCTA および，脳血管撮影では右後大脳動脈（P2）に動脈瘤の形成を認め，その遠位の閉塞が疑われた．以上より，感染性心内膜炎から脳塞栓症を来し，さらに感染性脳動脈瘤が形成されたと推察した．また虚血性病変は右外側後脈絡叢動脈の灌流域と診断した．外側後脈絡叢動脈に限局した脳梗塞は稀であり，またその鑑別診断には注意を要すると考えられた．
草刈機による頭蓋・顔面損傷に内視鏡を用いた再建術が有効だった1例を報告する. 60歳男性. 草刈機操作中に転倒, 刈刃が左顔面を直撃し搬送された. 左前額から眼球・頬部に至る切創あり, CTでは左前頭骨から眼窩・頬骨の骨損傷に, 左前頭葉挫傷・気脳症を合併した. 脳神経外科・眼科・形成外科で緊急手術を実施. 切創直下の骨欠損部の上端に穿頭し, 眼窩までの幅3cmを開頭した. 硬膜損傷部より硬性鏡を挿入, 左前頭葉の血腫・骨片の除去, 前頭蓋底の損傷硬膜の剝離・切除・縫縮, 前頭洞粘膜の剝離と有茎の骨膜組織の充塡を行った. 経過は良好で, 内視鏡での観察により, 元の切創を用いた小術野から深部の硬膜・頭蓋底の処置が可能であった.
Summary: Introduction: For acute ischemic stroke caused by large artery occlusion, prompt significant reperfusion is essential. Standardization of device selection and surgical techniques may be useful in this regard.
<sec> <title>BACKGROUND</title> Brain injuries resulting from motor vehicle accidents and falls, as well hypoxic insults other conditions, are one of the leading causes disability death in world. Current treatments limited but include continuous rehabilitation, especially for chronic brain injury. Recent studies have demonstrated that intravenous infusion mesenchymal stem cells (MSCs) has therapeutic efficacy several neurological diseases, including stroke spinal cord </sec>...