A5041967884- Pharmacological Effects of Natural Compounds
- Tea Polyphenols and Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle Physiology and Disorders
- Ginger and Zingiberaceae research
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacy and Medical Practices
- Advanced Chemical Sensor Technologies
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Heart Failure Treatment and Management
- Ginseng Biological Effects and Applications
- Exercise and Physiological Responses
- Pharmacogenetics and Drug Metabolism
- Alkaloids: synthesis and pharmacology
- Extracellular vesicles in disease
- Antioxidant Activity and Oxidative Stress
- Dysphagia Assessment and Management
- Phytochemicals and Antioxidant Activities
- Morinda citrifolia extract uses
- Potassium and Related Disorders
- Ocular Infections and Treatments
- Medication Adherence and Compliance
Kochi Medical School Hospital
2016-2025
Kōchi University
2011
Exosome-like nanoparticles (ELNs), which are plant-derived extracellular membrane vesicles, can regulate mammalian gene expression. ELNs cross the blood-brain barrier, making them potential therapeutic agents or drug-delivery carriers for neuroinflammation-related diseases. Here, we investigated anti-neuroinflammatory of extracted from Allium tuberosum (A-ELNs).A-ELNs were extracted, and their miRNA profile was characterized. A-ELNs also applied to BV-2 microglial MG-6 cells derived C57/BL6...
It has been reported that dogs are capable of identifying cancer in humans by detecting a specific odor: bladder urine odor and other cancers exhaled breath odor. However, no recognized indicates identified. In this study, we examined whether could be detected gas chromatography-mass spectrometry (GC-MS)-based metabolomics analysis Nine patients with 7 healthy controls were recruited as participants. Patients collected 3 d before for 3-7 after surgery. The concentrated was analyzed GC-MS...
Background Constipation frequently affects heart failure patients because of medication side effects and physiological the condition. Although recent speculation suggests that comorbid constipation may affect cardiovascular disease onset survival rates, this relationship remains unclear. We examined effect on with failure. Methods conducted a multicenter prospective cohort study (the Kochi YOSACOI study) hospitalized for acute decompensated The influence was evaluated using Cox regression...
Abstract Background Voriconazole (VRCZ) has non-linear pharmacokinetics, so personalized dosing based on pharmacokinetics is important. Approximately 20% of Asians are poor metabolizers CYP2C19. In Japan, challenges include rapid measurement VRCZ blood levels, feedback results to physicians, and therapeutic drug monitoring (TDM). The aim this study was evaluate the TDM implementation system for in outpatients. Methods Measurement outpatient started at Kochi medical school Hospital January...
Rehospitalization of patients with heart failure (HF) incurs high health care costs and increased mortality. Infection-related rehospitalizations in HF occur frequently, the risk increases age. This study aimed to identify factors associated infection-related older HF. Demographic, clinical, pharmacological data from 1061 acute who were enrolled Kochi Registry Subjects With Acute Decompensated Heart Failure (Kochi YOSACOI study) analyzed. Additionally, a machine learning approach was applied...
Background Exosome-like nanoparticles (ELNs) mediate interspecies intercellular communications and modulate gene expression. Hypothesis/Purpose In this study, we isolated purified ELNs from the dried rhizome of Atractylodes lancea (Thunb.) DC. [Asteraceae] (ALR-ELNs), a traditional natural medicine, investigated their potential as neuroinflammatory therapeutic agents. Methods ALR-ELN samples were using differential centrifugation, physical features microRNA contents analyzed through...
Aberrant melanin overproduction can significantly impact an individual's appearance and cause mental psychological distress. Current inhibitors of production exert harmful side effects due to inadequate selectivity; thus a need develop more selective synthesis is necessary. Extracellular vesicles are important agents intercellular signalling in prokaryotes eukaryotes. Recently, plant-derived nanoparticles, similar mammalian exosomes, have attracted attention for their use health research. In...
Non-alcoholic steatohepatitis is associated with the deposition of lipid droplets in liver, and characterised histologically by infiltration inflammatory cells, hepatocellular degeneration liver fibrosis. Oxidative stress may play an important role onset deterioration non-alcoholic steatohepatitis. We previously reported that Eriobotrya japonica seed extract, extracted 70% ethanol, exhibited antioxidant actions vitro vivo. In this study, we examined effect extract a rat model...
Yokukansan is a Kampo formula that commonly used by the elderly because it expected to improve peripheral symptoms of dementia and delirium. However, side effects from its use are frequently reported in elderly. In particular, pseudoaldosteronism caused licorice contained yokukansan leads hypertension, hypokalemia, muscle weakness, which may result death. This study aimed identify risk factors with use. Using cases Japanese Adverse Drug Report (JADER) database, reporting odds ratio (ROR) was...
Dyslipidaemia is a risk factor for arteriosclerosis. Recent studies have shown that dyslipidaemia effectively prevented by various polyphenols. In this clinical study (UMIN trial: 000024028), we evaluated the beneficial effects of polyphenols contained in Goishi tea on blood lipid profiles. Seventy-seven subjects with LDL cholesterol (CHO) ≧120 mg/mL were randomly divided into two groups 12 weeks polyphenol intake as follows: group daily consumption containing 122 mg and placebo...
Bangle (Zingiber purpureum) is a tropical ginger that used as spice in Southeast Asia. Phenylbutenoid dimers isolated from have exhibited neurotrophic effects primary cultured rat cortical neurons and PC12 cells. Furthermore, chronic treatment with phenylbutenoid enhances hippocampal neurogenesis olfactory bulbectomized mice. In this study, we investigated the of extract on behavior vivo. SAMP8 mice, which are an established model for accelerated aging, age-related learning memory...
We previously prepared and pharmaceutically evaluated ginger orally disintegrating (OD) tablets, optimized the base formulation, carried out a clinical trial in healthy adults their 20 s 50s to measure effect on salivary substance P (SP) level improved swallowing function. In this study, we conducted trials using OD tablets older people clinically evaluate improvements function resulting from functional components of tablet. The were by mixing excipients with same amount mannitol sucrose...
Individual differences in gut microbiota can affect the pharmacokinetics of drugs. Yokukansan is a traditional Japanese kampo medicine used to treat peripheral symptoms dementia and delirium. A study examining components yokukansan reported large individual glycyrrhizic acid (GL). It known that GL metabolized by intestinal bacteria glycyrrhetinic (GA), which absorbed gastrointestinal tract. Thus, may pharmacokinetics. We aimed clarify relationship between composition yokukansan. Mice were...
Aggression is the most common adverse effect of antiepileptic drugs (AEDs). This study aimed to investigate association aggression with AED use. The reporting odds ratio (ROR) from event reports, submitted Japanese Adverse Drug Event Report database between 2004 and 2020, was used calculate AEDs aggression. We also analyzed combined use relationship AED-associated patient characteristics. A total 433 patients developed Significant signals were detected for perampanel (crude ROR: 325.04, 95%...
In diabetic patients, skeletal muscle atrophy occurs due to increased oxidative stress and inflammation. Skeletal reduces the QOL of patients worsens life prognosis. Therefore, development preventive therapy for in hyperglycemic state is eagerly awaited. Juzentaihoto a medicinal herb that has function supplement physical strength, it expected prevent atrophy. To determine effect juzentaihoto on state, streptozotocin (STZ) was administered induce diabetes mice evaluated. Mice received extract...
Sarcopenia is a disease whose symptoms include decreased muscle mass and weakened strength with age. In sarcopenia, production of insulin-like growth factor-1 (IGF-1) increases ubiquitin ligases, such as Atrogin1 Muscle RING-Finger Protein-1 (MuRF1), by activating forkhead box O (FOXO), inflammatory cytokines oxidative stress increase the expression ligases transcription factor nuclear factor-kappa B (NF-κB). addition, increased levels cause skeletal atrophy. Conversely, sirtuin 1 (Sirt1)...
Deterioration of swallowing function leads to the risk aspiration pneumonia mortality. In elderly persons, decreased secretion substance P (SP) from oral and bronchial mucosae can lead reduced function. Capsaicin has been reported increase SP enhance We formulated orally disintegrating (OD) tablets consisting primarily ginger, which contains same vanillin derivatives as capsaicin, performed pharmaceutical evaluation a clinical study assess effect ginger on OD containing increased amount in...
In obese patients with type 2 diabetes, reduced insulin sensitivity, increased production of inflammatory cytokines, and oxidative stress were observed, which lead to decreased protein synthesis proteolysis in the skeletal muscles. Juzentaihoto (JTT) is herbal medicine we have previously reported that administration JTT hot water extract alleviates muscle atrophy a mouse model streptozotocin-induced 1 diabetes. this study, evaluated inhibitory effects on obesity was administered KKAy mice...