A5068669869- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
- Neuropeptides and Animal Physiology
- Congenital Heart Disease Studies
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Structural Anomalies and Repair
- Aortic aneurysm repair treatments
- Cardiac Ischemia and Reperfusion
- Cerebrovascular and Carotid Artery Diseases
- Cardiac tumors and thrombi
- Neurological Complications and Syndromes
- Muscle Physiology and Disorders
- Aortic Thrombus and Embolism
- Mechanical Circulatory Support Devices
- Abdominal vascular conditions and treatments
- Hedgehog Signaling Pathway Studies
- Restless Legs Syndrome Research
- Infective Endocarditis Diagnosis and Management
- Peroxisome Proliferator-Activated Receptors
- Infectious Aortic and Vascular Conditions
- Diagnosis and Treatment of Venous Diseases
- Conducting polymers and applications
- Pharmacy and Medical Practices
Kōchi University
2019-2024
Uji Hospital
1998-2023
Kochi Medical School Hospital
2020
Chikamori Hospital
2019
University of Karachi
2018
Nishi Niigata Chuo National Hospital
2013-2016
National Hospital Organization
2016
Feinstein Institute for Medical Research
2009
Northwell Health
2009
North Shore University Hospital
2006-2008
Milk fat globule epidermal growth factor 8 (MFG-E8) is a potent opsonin for the clearance of apoptotic cells and produced by mononuclear immune competent organs including spleen lungs. It attenuates chronic acute inflammation such as autoimmune glomerulonephritis bacterial sepsis enhancing cell clearance. Ischemia-reperfusion (I/R) injury gut results in severe inflammation, apoptosis, remote organ damage, lung (ALI).To determine whether MFG-E8 intestinal pulmonary after I/R.Wild-type (WT)...
ABSTRACT Introduction: In this study we sought to: (1) determine the distribution of GABA A receptors (GABA ‐Rs) in brain Duchenne muscular dystrophy (DMD) patients; and (2) ascertain if pattern correlates with cognitive dysfunction. Methods: Fourteen DMD patients [young adult ( n = 7, 18–25 years old) older 30–37 groups] 16 age‐matched normal volunteers participated. ‐R was assessed using 123 I‐IMZ‐SPECT. Neuropsychological assessments were performed 3 different test batteries, WAIS‐III,...
We recently demonstrated that early administration of rat adrenomedullin (AM), a vasoactive peptide, in combination with its binding protein (human AMBP-1) produces various beneficial effects sepsis. Human AM is 52-amino acid but differs from human AM, having only 50 amino residues, two deletions and six substitutions. It remains unknown whether AMBP-1 (AM/AMBP-1) also sepsis and, if so, AM/AMBP-1 reverses established rats. To test the AM/AMBP-1, we induced male adult rats by cecal ligation...
Segmental arterial mediolysis (SAM) is an uncommon vascular disease, which manifests as catastrophic intraabdominal hemorrhage caused by rupture of visceral dissecting aneurysms in most cases. The etiology SAM still unclear, but may be a vasospastic disorder and the responsible pressor agent norepinephrine. Recently, abdominal coexisting with intracranial has been reported, relationship between remains no cases concomitant ruptured saccular aneurysm have reported.A 49-year-old woman...
The cardioprotective efficacy of nicorandil in cardiac surgery was determined using a surgically relevant 4-hr cardioplegic arrest model. Each isolated rabbit heart parabiotically blood-perfused modified Langendorff column. magnitude left ventricular developed pressure and rate change over time were measured before (baseline) after ischemia. Nicorandil administered either pre-ischemia, post-ischemia, pre/post-ischemia, or continuously (before, during, ischemia). endothelium the coronary...
A 66-year-old man was transferred to our hospital with the diagnosis of a large thoracoabdominal aneurysm. Computed tomography showed thoracic vertebral erosion, suggesting chronic contained rupture. He hemodynamically stable no neurological complication preoperatively. underwent successful surgical replacement descending aorta. During surgery, 6th and 7th bones adjacent aneurysm were found be eroded. The postoperative course uneventful.
要旨:症例は16 歳女性で,両側もやもや病の保存的加療中に過眠症発作を来した.過眠発作の形式と脳波所見はナルコレプシーに類似していたが,診断基準からはナルコレプシーの診断に至らず,中枢性過眠症と診断した.右大脳半球に血行再建術を行ったところ,過眠発作が消失したため,本症例はもやもや病による症候性過眠症と診断した.脳血管障害による過眠症は稀ではあるが,もやもや病と中枢性過眠症とでは血行動態に類似する点もあり,もやもや病による血行力学的脳虚血が中枢性過眠症を引き起こす可能性がある.
Astroblastoma is a rare, supratentorial glial tumor, occurring predominantly in children and young adults. However, treatment strategies have not yet been established for this rare disease.A 6-year-old boy presented with headache nausea. CT MRI revealed left frontal mass lesion slight edema macrocalcifications. Gross tumor resection was performed. Histological examination found neoplastic cells astroblastic characteristics, striking perivascular array of pseudorosettes. The final diagnosis...
症例は70歳の女性．生直後より房室中隔欠損症を指摘されるも手術加療は行われなかった．今回心不全症状が出現し，加療目的に当院へ紹介となった．不完全型房室中隔欠損症（肺体血流比 4.46,中等度の左側房室弁逆流，心房粗動の診断となった．術中診断は膜様の心室中隔瘤を伴う中間型房室欠損症で，自己心膜パッチによる房室中隔欠損孔の閉鎖，左側房室弁形成術，右側房室弁形成術，不整脈手術を施行した．術後は心不全症状なく経過し，術後16日目に当科退院となった．本邦で高齢者の不完全型/中間型房室中隔欠損症の手術報告例は少ない．しかし，不完全型/中間型房室中隔欠損症は加齢とともに2次性変化により，心房細粗動や心不全などを発症する．外科治療成績は良好で運動耐容能の改善が期待されるため，高齢者であっても積極的に適応評価，外科的介入を行うべきだと考えられる．
大動脈弁二尖弁に巨大非破裂バルサルバ洞動脈瘤を合併した稀な症例を経験した. 症例は47歳, 男性. 小児期より弁膜症を指摘されていたが精査は受けておらず, 最近生じてきた嚥下時の違和感により受診した. 検査の結果, 心右側に突出した70×70mm大の巨大非破裂バルサルバ洞動脈瘤と高度の大動脈弁閉鎖不全および狭窄を認めた. 術中所見で弁尖の硬化を伴った大動脈弁二尖弁を認め, 上行大動脈最大径は42mmと拡張しており, modified Bentall 手術 (Carrel patch 法) を行った. 病理所見は硬化性病変が主体で一部に中膜の変性を認めた.
今回われわれは心房細動による心内血栓が原因と思われる急性大動脈閉塞症の2例を経験し, 迅速な診断治療にて救命しえたので報告する. 症例はそれぞれ58歳男性, 60歳女性. 発症より約5.5時間後, 4時間後に手術を行い, 血栓摘除術にて血行再建しえた. Myonephropathic metabolic syndrome (MNMS) 防止のため, 血行再建時におのおの約2,000ml, 1,000mlの瀉血を大腿静脈より行い, 潟血血液は自己血回収回路により洗浄赤血球とし輸血した. 術後ミオグロビン尿が疑われたが, 輸液, 利尿剤投与による尿量維持, 電解質補正, アシドーシス補正によりMNMSの発症は認めなかった. 再灌流直後の患肢静脈血瀉血と自己血回収回路による返血は有効であったと思われた.