A5073178915- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- X-ray Spectroscopy and Fluorescence Analysis
- Acute Ischemic Stroke Management
- Medical Imaging Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Meningioma and schwannoma management
- Growth Hormone and Insulin-like Growth Factors
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Pituitary Gland Disorders and Treatments
- Nuclear Physics and Applications
- Atomic and Molecular Physics
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Ion-surface interactions and analysis
- Pluripotent Stem Cells Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Pathology Studies
- Electron and X-Ray Spectroscopy Techniques
- Advanced X-ray Imaging Techniques
Kochi Medical School Hospital
2019-2025
Kōchi University
2018-2025
Akebono (Japan)
2024
Tokyo Institute of Technology
2013-2023
Neurological Surgery
2013-2023
Cornell University
2013-2023
Weill Cornell Medicine
2023
Shinshu University
2023
Himeji Medical Center
2010-2022
National Hospital Organization
2010-2022
Parkinson disease (PD) is a neurodegenerative disorder characterized by loss of midbrain dopaminergic (DA) neurons. ES cells are currently the most promising donor cell source for cell-replacement therapy in PD. We previously described strong neuralizing activity present on surface stromal cells, named cell–derived inducing (SDIA). In this study, we generated neurospheres composed neural progenitors from monkey which capable producing large numbers DA demonstrated that FGF20, preferentially...
To develop and validate a set of practical prediction tools that reliably estimate the outcome subarachnoid haemorrhage from ruptured intracranial aneurysms (SAH).Cohort study with logistic regression analysis to combine predictors treatment modality.Subarachnoid Haemorrhage International Trialists' (SAHIT) data repository, including randomised clinical trials, prospective observational studies, hospital registries.Researchers collaborated pool datasets registries, trials SAH multiple...
Rho-GTPase has been implicated in the apoptosis of many cell types, including neurons, but mechanism by which it acts is not fully understood. Here, we investigate roles Rho and ROCK during transplantation embryonic stem cell-derived neural precursor cells. We find that dissociation precursors activates induces apoptosis. Treatment with inhibitor C3 exoenzyme and/or Y-27632 decreases amount dissociation-induced (anoikis) 20-30%. Membrane blebbing, an early morphological sign apoptosis;...
The differentiation of dopaminergic (DA) neurons from mouse embryonic stem cells (ESCs) can be efficiently induced, making these a potential source for transplantation as treatment Parkinson's disease, condition characterized by the gradual loss midbrain DA neurons. One major persistent obstacles to successful implementation therapeutic ESC is propensity ESC-derived grafts form tumors in vivo. To address this problem, we used fluorescence-activated cell sorting purify neural precursors...
Transplantation of stem cells has the possibility restoring neural functions after stroke damage. Therefore, we transplanted neuronal progenitors generated from monkey embryonic (ES) into ischemic mouse brain to test this possibility. Monkey ES were caused differentiate by stromal cell-derived inducing activity method. Focal cerebral ischemia was induced occluding middle artery intraluminal filament technique. The donor lateral striatum at 24 h start reperfusion. became located widely around...
TSH, T4and T3 were measured by radioimmunoassay in plasma samples obtained from 77 young adult male and 114 female rats fed a Purina high-iodine diet maintained an isolated room, 2-4/cage, at 24 ± 1 C with light 0600-1800 h. In one experiment, 7 decapitated every 3 h for 30 consecutive bunk blood was collected. There clear nyctohemeral rhythm of TSH both sexes characterized zenith 1200 nadir between 1800 2100 The cycle approximately 180° out phase negatively correlated (P < .05) that...
Background and Purpose Several reports have stated that the periventricular abnormalities found on T 2 -weighted MRI or CT are associated with age hypertension. However, there been no effect of hypertension treatment white matter abnormalities. We studied association between cardiovascular risk factors hyperintensities (PVHs) differences treated untreated hypertensive subjects in extent PVHs. Methods The PVH observed 238 scans was assessed retrospectively patients older than 40 years use a...
We studied the associations of mental deterioration and blood pressure with severity location lesions in cerebral white matter 35 patients (27 men eight women) aged 52-84 (mean 70.9) years multiple lacunar infarcts; 21 had no dementia 14 were demented. Using magnetic resonance imaging to evaluate lesion severity, we determined that demented more severe than nondemented patients; this difference was especially prominent for frontal lobe (p less 0.001). Score on rating scale Hasegawa et al...
Abstract The study reports the development of a solution‐processed phosphorescent tandem organic light‐emitting device (OLED) exhibiting extremely small efficiency roll‐off. OLED comprises two units (LEUs) connected by an interconnecting unit and employs thermally activated delayed fluorescence host material. One most difficult tasks in fabrication OLEDs is to form multilayer structure without dissolving underlayer during coating upper layer. developed materials exhibit high tolerance...
Life most likely started during the Hadean Eon; however, environmental conditions which contributed to complexity of its chemistry are poorly known. A better understanding various conditions, including global (heliospheric) and local (atmospheric, surface, oceanic), along with internal dynamic early Earth, required understand onset abiogenesis. Herein, we examine contributions galactic cosmic rays (GCRs) solar energetic particles (SEPs) associated superflares from young Sun formation amino...
OBJECTIVE Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality rates. In particular, functional outcomes of SAH caused by large or giant (≥ 10 mm) ruptured intracranial aneurysms are worsened procedure-related complication However, studies describing the risk factors for poor specific to large/giant sparse. addition, recurrence rebleeding rates following treatment such remain a concern. This study aimed clarify short-term long-term durability due using...
Rehospitalization of patients with heart failure (HF) incurs high health care costs and increased mortality. Infection-related rehospitalizations in HF occur frequently, the risk increases age. This study aimed to identify factors associated infection-related older HF. Demographic, clinical, pharmacological data from 1061 acute who were enrolled Kochi Registry Subjects With Acute Decompensated Heart Failure (Kochi YOSACOI study) analyzed. Additionally, a machine learning approach was applied...
To describe the treatment outcomes of epidural blood patch (EBP) guided by a novel overflow leak test (OLT) combined with computed tomography myelography (CTM) in patients intracranial hypotension, focus on consistency and discrepancy between CTM OLT findings METHODS: followed was performed 18 adults CSF pressure ≤60 mmH2O. Patients were categorized according to or findings: Group A, matching signals OLT; B, detected only; C, signal sites D, no both OLT. EBPs applied policy, associations...
Dynamic changes in the pituitary-thyroid axis were studied during pregnancy and lactation by measuring plasma concentrations of TSH, T4, T3 free T4 fraction (FT4F) rat. In contrast to human pregnancy, progressively decreased second half as low 2.6 ±0.2 /μg/dl term compared with 6.3 ± 0.3 on day 0 (P < 0.01). Plasma concentration underwent a smaller proportional decrease than (66.5 6.2 ng/dl at vs. 44.6 4.9 term; P 0.05). Despite dramatic drop T4) TSH remained normal levels until 16th after...
Objective To describe the microanatomy of meningo-orbital band (MOB) and its associated membranes, propose a stepwise method for their detachment while minimizing potential complications. Design Cadaveric prospective clinical. Setting Microneurosurgery Skull Base Laboratory, Weill Cornell Medical College (New York, NY) Shiroyama Hospital (Osaka, Japan). Participants Five preserved cadaveric heads (10 sides) five patients requiring surgical MOB in 2012. Results subsequent extradural anterior...
Parkinson disease (PD) is a neurodegenerative disorder characterized by loss of midbrain dopaminergic (DA) neurons. ES cells are currently the most promising donor cell source for cell-replacement therapy in PD. We previously described strong neuralizing activity present on surface stromal cells, named cell–derived inducing (SDIA). In this study, we generated neurospheres composed neural progenitors from monkey which capable producing large numbers DA demonstrated that FGF20, preferentially...
Abstract Parkinson's disease is characterized by a loss of midbrain dopamine (DA) neurons and generally viewed as potential target for stem cell therapy. Although several studies have reported the generation postmitotic DA from embryonic (ES) cells, it unknown whether proliferative progenitors can be isolated in vitro. To investigate this possibility, we developed combined approach which ES cells are cocultured with PA6 stromal to expose them cell‐derived inducing activity (SDIA) then...
We have measured plasma thyroxine (T4), triiodothyronine (T3), and TSH with specific radioimmunoassays in rats during adaptation to severe iodine deficiency after they had previously received regimens supplying various quantities of iodine. Rats were maintained on a high-iodine diet (HID) containing 3 mg iodine⁄kg or low-iodine (LID) 30 fig supplemented 0.1, 0.2, 0.4 iodine⁄ml drinking water before switching LID alone. Frequent serial blood samples obtained up months, using 6 more animals...