A5075048849- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Cardiac Imaging and Diagnostics
- Laser Applications in Dentistry and Medicine
- MRI in cancer diagnosis
- Neurogenesis and neuroplasticity mechanisms
- Transcranial Magnetic Stimulation Studies
- Gastric Cancer Management and Outcomes
- Neural dynamics and brain function
- Pluripotent Stem Cells Research
- Neurological disorders and treatments
- Dermatologic Treatments and Research
- Lanthanide and Transition Metal Complexes
- Cerebrovascular and Carotid Artery Diseases
- Neural and Behavioral Psychology Studies
- Primate Behavior and Ecology
- Glioma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Memory and Neural Mechanisms
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Mesenchymal stem cell research
RIKEN Center for Biosystems Dynamics Research
2018-2025
University of Tokyo Hospital
2025
Ibaraki University
2024
Hitachi (Japan)
2024
Kyoto University
2002-2024
Nara Women's University
2007-2024
Osaka Sangyo University
2023-2024
Nagoya University
2018-2022
Systems Dynamics (United States)
2022
Utsunomiya University
2021
Parkinson disease (PD) is a neurodegenerative disorder characterized by loss of midbrain dopaminergic (DA) neurons. ES cells are currently the most promising donor cell source for cell-replacement therapy in PD. We previously described strong neuralizing activity present on surface stromal cells, named cell–derived inducing (SDIA). In this study, we generated neurospheres composed neural progenitors from monkey which capable producing large numbers DA demonstrated that FGF20, preferentially...
Induced pluripotent stem cells (iPSCs) provide the potential for autologous transplantation using derived from a patient's own cells. However, immunogenicity of iPSCs or their derivatives has been matter controversy, and up to now there no direct comparison allogeneic in brains humans nonhuman primates. Here, primates, we found that iPSC-derived neurons elicited only minimal immune response brain. In contrast, allografts caused an acquired with activation microglia (IBA-1(+)/MHC class II(+))...
Drug-related cues induce craving, which may perpetuate drug use or trigger relapse in addicted individuals. Craving is also under the influence of other factors daily life, such as availability and self-control. Neuroimaging studies using cue paradigms have shown frontal lobe involvement this contextual on reactivity, but not clarified how area accounts for phenomenon. We explored contributions to cue-induced craving different intertemporal conditions by combining transcranial magnetic...
The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we show the efficacy major histocompatibility complex (MHC)-matched allogeneic neural grafting in brain, which less immune-responsive tissue, using iPSCs derived from an MHC homozygous cynomolgus macaque. Positron emission tomography imaging reveals neuroinflammation...
We present distinct patterns of neurite distribution in the human cerebral cortex using diffusion magnetic resonance imaging (MRI). analyzed both high-resolution structural (T1w and T2w images) MRI data 505 subjects from Human Connectome Project. Neurite distributions were evaluated orientation dispersion density (NODDI) model, optimized for gray matter, mapped onto cortical surface a method weighted towards mid-thickness to reduce partial volume effects. The estimated was high somatosensory...
Advances in neuroimaging and neuroanatomy have yielded major insights concerning fundamental principles of cortical organization evolution, thus speaking to how well different species serve as models for human brain function health disease. Here, we focus on folding, parcellation, connectivity mice, marmosets, macaques, humans. Cortical folding patterns vary dramatically across species, individual variability increases with surface area. Such issues are best analyzed using surface-based...
Single photon emission computed tomography was used to evaluate regional cerebral blood flow changes during gait on a treadmill in 10 patients with Parkinson's disease and age-matched controls. The subjects were injected [99mTc]hexamethyl-propyleneamine oxime twice: while walking the treadmill, which moved at steady speed, lying bed their eyes open. On all walked same speed preferred stride length. showed typical hypokinetic higher cadence smaller length than In controls, gait-induced...
Neuropsychological tests that require shifting an attentional set, such as the Wisconsin Card Sorting Test, are sensitive to frontal lobe damage. Although little information is available for humans, animal experiment suggested different regions of prefrontal cortex may contribute set behavior at levels processing. Behavioral studies also suggest trials more time consuming than non-set (i.e. switch cost) and this be underpinned by differences neural level. We determined whether there were...
Increasing evidence points to a role for circulating endothelial progenitor cells, including populations of CD34- and CD133-positive cells present in peripheral blood, maintenance the vasculature neovascularization. Immature populations, CD34-positive have been shown contribute vascular homeostasis, not only as pool but also source growth/angiogenesis factors at ischemic loci. We hypothesized that diminished numbers immature might impair such physiological reparative processes, potentially...
For the safe clinical application of embryonic stem cells (ESCs) for neurological diseases, it is critical to evaluate tumorigenicity and function human ESC (hESC)‐derived neural in primates. We have herein, first time, compared growth hESC‐derived with different stages differentiation implanted brains primate models Parkinson's disease. herein show that residual undifferentiated expressing markers present cell preparation can induce tumor formation monkey brain. In contrast, a matured by...
Before induced pluripotent stem cells (iPSCs) can be used to treat neurologic diseases, human iPSC-derived neural must analyzed in the primate brain. In fact, although mouse and iPSCs have been generate dopaminergic (DA) neuron
The question of how intensive motor training restores function after brain damage or stroke remains unresolved. Here we show that the ipsilesional ventral premotor cortex (PMv) and perilesional primary (M1) rhesus macaque monkeys are involved in recovery manual dexterity a lesion M1. A focal hand digit area M1 was made by means ibotenic acid injection. This initially caused flaccid paralysis contralateral but followed functional movements, including precision grip, during course daily...
Macaque monkeys are an important animal model where invasive investigations can lead to a better understanding of the cortical organization primates including humans. However, tools and methods for noninvasive image acquisition (e.g. MRI RF coils pulse sequence protocols) data preprocessing have lagged behind those developed To resolve structural functional characteristics smaller macaque brain, high spatial, temporal, angular resolutions combined with signal-to-noise ratio required ensure...
T1-weighted divided by T2-weighted (T1w/T2w) myelin maps were initially developed for neuroanatomical analyses such as identifying cortical areas, but they are increasingly used in statistical comparisons across individuals and groups with other variables of interest. Existing T1w/T2w contain radiofrequency transmit field (B1+) biases, which may be correlated these interest, leading to potentially spurious results. Here we propose two empirical methods correcting biases using either explicit...
The mechanism of motor recovery after stroke may involve reorganization the surviving networks. However, details adaptive changes in structural connectivity are not well understood. Here, we show long-term white matter microstructure that relate to patients. We studied ten subcortical ischemic patients who showed hemiparesis at initial clinical examination and an infarcted lesion centered posterior limb internal capsule unilateral hemisphere diffusion-weighted magnetic resonance imaging...
A cell-based therapy for the replacement of dopaminergic neurons has been a long-term goal in Parkinson’s disease research. Here, we show that autologous engraftment A9 neuron-like cells induced from mesenchymal stem (MSCs) leads to survival and restoration motor function hemiparkinsonian macaques. Differentiated MSCs expressed markers released dopamine after depolarization vitro. The differentiated were engrafted affected portion striatum. Animals received transplants showed modest gradual...
Diffusion tensor imaging (DTI) and neurite orientation dispersion density (NODDI) are widely used models to infer microstructural features in the brain from diffusion-weighted MRI. Several studies have recently applied both increase sensitivity biological changes, however, it remains uncertain how these measures associated. Here we show that cortical distributions of DTI NODDI associated depending on choice b-value, a factor reflecting strength diffusion weighting gradient. We analyzed...
Psychiatric and neurological disorders are afflictions of the brain that can affect individuals throughout their lifespan. Many magnetic resonance imaging (MRI) studies have been conducted; however, imaging-based biomarkers not yet well established for diagnostic therapeutic use. This article describes an outline planned study, Brain/MINDS Beyond human MRI project (BMB-HBM, FY2018 ~ FY2023), which aims to establish clinically-relevant with multi-site harmonization by collecting data from...