A5067216256- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Neurological Complications and Syndromes
- Mesenchymal stem cell research
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Pituitary Gland Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Stroke Rehabilitation and Recovery
- Aortic Disease and Treatment Approaches
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Aortic aneurysm repair treatments
- Brain Metastases and Treatment
- Nerve injury and regeneration
- Venous Thromboembolism Diagnosis and Management
Hiroshima University
2022-2025
Nagasaki University
2014-2024
Hiroshima University Hospital
2022-2024
KU Leuven
2024
Nagasaki University Hospital
2012-2023
Hiroshima Prefectural Hospital
2022
Hiroshima University of Economics
2022
Takeda (United States)
2022
Hiroshima City Asa Citizens Hospital
2021
Hokkaido University Hospital
2018
Background and Purpose— About one half of those who develop adult-onset moyamoya disease experience intracranial hemorrhage. Despite the extremely high frequency rebleeding attacks poor prognosis, measures to prevent have not been established. The purpose this study is determine whether extracranial–intracranial bypass can reduce incidence improve patient prognosis. Methods— This was a multicentered, prospective, randomized, controlled trial conducted by 22 institutes in Japan. Adult...
Stem cell transplantation promises new hope for the treatment of stroke although significant questions remain about how grafted cells elicit their effects. One hypothesis is that transplanted stem enhance endogenous repair mechanisms activated after cerebral ischaemia. Recognizing bilateral reorganization surviving circuits associated with recovery stroke, we investigated ability human neural progenitor to this structural plasticity. Our results show first evidence can significantly increase...
Cell transplantation offers a novel therapeutic strategy for stroke; however, how transplanted cells function in vivo is poorly understood. We show the first time that after subacute into ischemic brain of human central nervous system stem grown as neurospheres (hCNS-SCns), cell-secreted factor, vascular endothelial growth factor (hVEGF), necessary cell-induced functional recovery. correlate this recovery to hVEGF-induced effects on host including multiple facets repair and its unexpected...
Abstract: Though melatonin has a wide variety of biological functions, its effects on the neural stem cells (NSCs) is still unknown. In this study, we examined at either physiological (0.01–10 n m ) or pharmacological concentrations (1–100 μ proliferation and astroglial differentiation NSCs derived from mouse embryo striatum using an in vitro culture system. We found that concentrations, but not suppressed epidermal growth factor (EGF)‐stimulated NSC (increment viable cells, DNA synthesis...
Background and Purpose— The primary results of the Japan Adult Moyamoya Trial revealed statistically marginal superiority bypass surgery over medical treatment alone in preventing rebleeding moyamoya disease. purpose this analysis is to test prespecified subgroup hypothesis that natural course surgical effects vary depending on hemorrhagic site at onset. Methods— site, classified as either anterior or posterior, was only stratifying variable for randomization. Statistical analyses were...
Long-term outcomes are unknown in patients with asymptomatic moyamoya disease. In this report, we aimed to clarify their 5-year risk of stroke and its predictors.We conducting a multicenter, prospective cohort study (Asymptomatic Moyamoya Registry) Japan. Participants were eligible if they 20 70 years, had bilateral or unilateral disease, experienced no episodes suggestive TIA stroke; functionally independent (modified Rankin Scale score 0-1). Demographic radiological information was...
Background and Purpose— Intra-arterial cell transplantation offers a novel therapeutic strategy for stroke; however, it remains unclear how the timing of administration affects distribution, brain repair processes, functional recovery. Here, we investigate hypothesis that changes behavior graft host environment in way Methods— Rats received human mesenchymal stem cells via internal carotid artery at 1, 4, or 7 days (D1, D4, D7) after middle cerebral occlusion reperfusion. Animals were...
The WHO classification of central nervous system tumors (5th edition) classified astrocytoma, IDH-mutant accompanied with CDKN2A/B homozygous deletion as grade 4. Loss immunohistochemical (IHC) staining for methylthioadenosine phosphorylase (MTAP) was developed a surrogate marker CDKN2A-HD. Identification imaging biomarkers CDKN2A status is immense clinical relevance. In this study, we explored the association between radiological characteristics non-enhancing to status.
<h3>BACKGROUND AND PURPOSE:</h3> SWI is a high spatial resolution MR imaging technique showing magnetic inhomogeneity that could demonstrate increased oxygen extraction in focal cerebral ischemia. The aim of this study was to investigate the characteristics signal intensity DMVs by using and determine whether method indicate severity hemodynamics MMD evaluating correlation between stage on SPECT. <h3>MATERIALS METHODS:</h3> Consecutive patients were prospectively analyzed before treatment....
Abstract Purpose The T2-FLAIR mismatch sign is a highly specific diagnostic imaging biomarker for astrocytoma, IDH-mutant. However, definitive prognostic has yet to be identified. This study investigated markers, specifically analyzing T2-weighted and FLAIR images of this tumor. Methods We retrospectively analyzed 31 cases non-enhancing IDH-mutant treated at our institution, 30 from Cancer Genome Atlas (TCGA)/The Imaging Archive (TCIA). defined “super sign” as having significantly strong low...
Abstract Introduction The T2-FLAIR mismatch sign is a characteristic imaging biomarker for astrocytoma, isocitrate dehydrogenase (IDH)-mutant. However, investigators have provided varying interpretations of the positivity/negativity this given individual cases nature qualitative visual assessment. Moreover, MR sequence parameters also influence appearance sign. To resolve these issues, we used synthetic technique to quantitatively evaluate and differentiate astrocytoma from...
OBJECTIVE An MRI protocol for germinoma surveillance after complete remission has not been established. Moreover, the standard treatment recurrent or refractory determined. In this study, authors explored imaging characteristics of and discuss their institution’s experience with multidisciplinary malignancy. METHODS The medical records 16 patients (14 male, 2 female) 62 (52 10 without recurrence who were treated at authors’ institution between 1989 2023 retrospectively examined. Data...
In recent years, the Japanese neurosurgical field has been added to guidelines for appropriate use of antimicrobial agents prevention surgical site infection; however, awareness neurosurgeons and specific methods infection in remains unclear. Therefore, we report a repeat survey conducted after addition on compare it with our previous 2018. A questionnaire-based was via Internet among members Neurosurgical Society Chemotherapy. The response rate 34.1% (270/792). More than 90% respondents...
Brain dock is used for the early diagnosis of intracranial lesions, prevention cerebrovascular disorders, and detection cognitive decline. However, its application varies per facility. This study evaluated use brain compliance with guidelines via a questionnaire survey on members Japan Society Ningen Dock Preventive Medical Care Society. The included information respondents, facility characteristics, implementation. number responses was 288 (response rate: 10.3%). predominantly in...
Cell transplantation therapy offers great potential to improve impairments after stroke. However, the importance of donor age on therapeutic efficacy is unclear. We investigated regenerative capacity transplanted cells focusing (young vs. old) for ischaemic The quantities human mesenchymal stem cell (hMSC) secreted brain-derived neurotrophic factor in vitro and monocyte chemotactic protein-1 at day 7 vivo were both significantly higher young hMSC compared with old hMSC. Male Sprague-Dawley...