A5102742901- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Brain Metastases and Treatment
- Cancer-related Molecular Pathways
- Spinal Fractures and Fixation Techniques
- Microtubule and mitosis dynamics
- Neurofibromatosis and Schwannoma Cases
- Neonatal and fetal brain pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience of respiration and sleep
- Spinal Cord Injury Research
- Congenital gastrointestinal and neural anomalies
- Agricultural Productivity and Crop Improvement
- Systemic Lupus Erythematosus Research
- Traumatic Brain Injury Research
- Drug-Induced Ocular Toxicity
- Retinoids in leukemia and cellular processes
Shimane Prefectural Central Hospital
2015-2025
Hiroshima University
2006-2021
Hidaka Hospital
2020
Hiroshima City University
2011
Minamiaoyama Eye Clinic
2010
Miyazaki Welfare Medical College
2005
The University of Texas MD Anderson Cancer Center
2005
Kurume University
1968
Glioblastoma is characterised by invasive growth and a high degree of radioresistance. Survivin, regulator chromosome segregation, highly expressed known to induce radioresistance in human gliomas. In this study, we examined the effect survivin suppression on radiosensitivity malignant glioma cells, while focusing centrosome aberration instability (CIN). We suppressed small interfering RNA transfection, using clonogenic assay trypan blue exclusion U251MG (p53 mutant) D54MG wild type) cells....
Abstract BACKGROUND. Geminin is a nuclear protein that belongs to the DNA replication inhibitor group. It inhibits by preventing Cdt1 from loading minichromosome maintenance onto chromatin, as required for replication. For this study, authors investigated geminin expression in high‐grade astrocytic tumors, including anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM), with view predicting clinical outcomes on basis patients these malignant brain tumors. METHODS....
The characteristics of cerebral aneurysms in Japan differ from other countries the higher incidence unruptured aneurysm detected by brain check-up screening, rupture rate aneurysm, subarachnoid hemorrhage, and superior outcome after hemorrhage based on meta-analysis. Head shape, genetic features, environmental factors, demographics, medical system are also different countries. Unruptured 2.8 times more likely to Japanese than western aneurysms, resulting highest world. exact specific...
A 35-year-old man presented with penetrating spinal injury after attempting suicide by stabbing a wooden chopstick into his mouth. The object penetrated the pharynx, and tip entered canal of atlantoaxial vertebrae. Emergent surgery disclosed that had between dural sac vertebral artery. There was no tear or artery injury. foreign body removed successfully from oral side. He recovered without neurological sequelae.
We evaluated the outcomes of endovascular or surgical treatment ruptured vertebral artery dissecting aneurysms (VADAs), and investigated relations between complications development location posterior inferior cerebellar (PICA). treated 14 patients (12 men, two women; mean age, 56.2 years) with VADAs March 1999 June 2012 at our hospital. Six eight had Hunt Hess grades 1–3 4–5, respectively. Twelve underwent internal trapping, one proximal occlusion alone, in acute stage occipital (OA)-PICA...
This study aimed to determine the prevalence and risk factors for brain white matter changes in normal young middle-aged participants who underwent Brain Dock (brain screening). We analyzed 5,000 consecutive healthy from registry between August December 2018. Age, sex, body mass index (BMI), medical history, deep subcortical high intensity (DSWMH), periventricular (PVH), enlargement of perivascular space (EPVS) were investigated relation age. The DSWMH, PVH, EPVS 35.3%, 14.0%, 17.8%,...
Various guidelines regarding surgical site infection (SSI) have recently been established. However, perioperative management of the wound and use antibiotics never standardized completely in departments neurosurgery Japan. This survey investigated current administration antibiotic prophylaxis (SAP) compared with intended to reduce SSI associated Questionnaires were distributed members conference on Neurosurgical Techniques Tools Japan Society Aesthetic Neurosurgery via internet. The...
An internal carotid artery (ICA) pseudoaneurysm associated with neurofibromatosis type 1 (NF-1) is rare. We report the first case of unruptured extracranial ICA in a patient NF-1 successfully treated endovascular stenting and coil embolization.A 66-year-old woman diagnosed had sudden left neck pain massive swelling 3 years earlier. Radiological examination showed ruptured thoracic (ITA). The posttreatment computed tomography (CT) scan revealed complete obliteration aneurysm ITA an right ICA....
The "Izumo Study" revealed the incidence rate of subarachnoid hemorrhage (SAH) in Izumo City, Shimane Prefecture, Japan, from 1980 to 1998. However, no study has been published regarding SAH Prefecture after Most studies reporting Japan have conducted before 2000, although a few reported 2000. This aimed assess estimated age-adjusted (AAIR) 1998, following Study. A retrospective was identify AAIR using mortality for this population 1999 2017 and assuming that case-fatality decreased by 0.7%...
The incidences of subarachnoid hemorrhage (SAH) in Finland and Japan are the highest world, with about 20-23 cases per 100,000 persons year. Since report International Subarachnoid Aneurysm Trial (ISAT) was published, use intravascular coil embolization (CE) for cerebral aneurysm has become more frequent worldwide. In this paper, we discuss current situation therapy according to data our institute, Standard Stroke Registry Study, Neurosurgical Society.From 1999 2013, 543 ruptured saccular...
Multiple primitive intracranial tumors with different histological characteristics are uncommon.Although coexistence of a medulloblastoma glial has been reported in children, is rarely found adults, especially those older than 40 years age.We present an extremely rare case developing 40-year-old male undergoing maintenance chemotherapy for anaplastic astrocytoma 21 months after radiotherapy.Initially, he complained intractable epilepsy characterized by complex partial seizures.Magnetic...