A5079975386- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Neurological Complications and Syndromes
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Lipoproteins and Cardiovascular Health
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- Brain Metastases and Treatment
- Cerebrovascular and genetic disorders
- Neurosurgical Procedures and Complications
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Advanced Neuroimaging Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cerebrospinal fluid and hydrocephalus
Kyoto University
2016-2025
Kyoto University Hospital
2005-2025
Kyoto City Hospital
2022
Kobe City Medical Center General Hospital
2013-2022
Kyoto University of Education
2020
National Cerebral and Cardiovascular Center
2008-2019
Hokuriku Electric Power Company (Japan)
2007-2019
Osaka Red Cross Hospital
2019
Nihon University
1967-2018
Ehime University
2018
Background Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its susceptibility locus has been mapped to 17q25.3 in Japanese families, but the gene unknown. Methodology/Principal Findings Genome-wide linkage analysis eight three-generation families with moyamoya revealed (P<10-4). Fine mapping demonstrated a 1.5-Mb bounded by D17S1806 and rs2280147. We conducted exome index cases these results filtered through Ng criteria. There was variant p.N321S PCMTD1 p.R4810K...
Background and Purpose— About one half of those who develop adult-onset moyamoya disease experience intracranial hemorrhage. Despite the extremely high frequency rebleeding attacks poor prognosis, measures to prevent have not been established. The purpose this study is determine whether extracranial–intracranial bypass can reduce incidence improve patient prognosis. Methods— This was a multicentered, prospective, randomized, controlled trial conducted by 22 institutes in Japan. Adult...
Background and Purpose— The Middle Cerebral Artery Embolism Local Fibrinolytic Intervention Trial (MELT) Japan was organized to determine the safety clinical efficacy of intraarterial infusion urokinase (UK) in patients with stroke within 6 hours onset. Methods— Patients ischemic presenting onset displaying occlusions M1 or M2 portion middle cerebral artery on carotid angiography were randomized UK control groups. Clinical outcome assessed by modified Rankin Scale, National Institutes Health...
Oxidized LDL (Ox-LDL) seems to play key roles in atherogenesis. Lectinlike Ox-LDL receptor-1 (LOX-1) is a recently identified cell-surface receptor for Ox-LDL. The relationship of this novel atherogenesis, however, has not yet been clarified. In study, we explored the expression LOX-1 atherosclerotic lesions human carotid arteries.Using endarterectomy specimens obtained from 21 patients and 2 samples normal aortas, examined by reverse transcription-polymerase chain reaction...
Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it not clearly determined whether with SRS as effective that WBRT or plus SRS. We thus assessed noninferiority salvage in patients BMs. Patients and Methods age 20 79 years old performance status scores 0 2-and 3 if caused only by neurologic deficits-and four fewer surgically resected BMs...
In this report, we, the Research Committee on Moyamoya Disease (Spontaneous Occlusion of circle Willis), describe in detail changes new "Diagnostic Criteria 2021" for moyamoya disease and its scientific basis to make it widely known world. The revised criteria cover all aspects disease, including a definition concept, diagnostic imaging, concept quasi-moyamoya (moyamoya syndrome).
The revised Japan Stroke Society Guidelines for the Treatment of were published in Japanese July 2021. In this article, extracted recommendation statements are published. revision keeps pace with great progress stroke control based on recently enacted Basic Act and Cardiovascular Disease Japan. guideline covers following areas: primary prevention, general acute management stroke, ischemic transient attack, intracerebral hemorrhage, subarachnoid asymptomatic cerebrovascular disease, other...
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly the white matter. These were associated with matter already young adults ( N = 1,748; 22.1 2.3 yr) enriched early-onset...
Parkinson's disease is caused by the loss of dopamine neurons, causing motor symptoms. Initial cell therapies using fetal tissues showed promise but had complications and ethical concerns1-5. Pluripotent stem (PS) cells emerged as a promising alternative for developing safe effective treatments6. In this phase I/II trial at Kyoto University Hospital, seven patients (ages 50-69) received bilateral transplantation dopaminergic progenitors derived from induced PS (iPS) cells. Primary outcomes...
We studied the effects of ML-236B, a competitive inhibitor 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, on serum levels lipoproteins and ubiquinone-10 in seven heterozygous patients with familial hypercholesterolemia. ML-236B was given at doses 30 to 60 mg per day for 24 weeks. Serum cholesterol decreased from 390±9 303±8 deciliter (10.1 ±0.2 7.88±0.2 mmol liter, mean ±S.E.M.; P<0.001), triglyceride 137±18 87±9 (1.55±0.20 0.98±0.1 liter; P<0.05)....
The relationship between the concentrations of intermediate-density lipoprotein (IDL) and other lipoproteins extent coronary artery disease (CAD) was studied in 182 consecutive patients evaluated by selective cineangiography. On univariate analysis, CAD correlated significantly positively with very low density (VLDL) cholesterol, IDL cholesterol low-density (LDL) negatively high-density (HDL) cholesterol. Analysis four subgroups divided LDL levels indicated that moderately increased were...
Oxidized low density lipoprotein (Ox-LDL) induces apoptosis in vascular smooth muscle cells (VSMCs), which may increase atherosclerotic plaque instability. In this study, we examined the molecular mechanisms causing Ox-LDL-induced VSMCs, especially focusing on involvement of Bax/Bcl-2 and lectinlike Ox-LDL receptor-1 (LOX-1). cultured bovine aortic (BASMCs), at high concentrations (>60 microg/mL) induced cell death as demonstrated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium...
Cerebral aneurysm is a frequent cerebrovascular event and major cause of fatal subarachnoid haemorrhage, but there no medical treatment for this condition. Haemodynamic stress and, recently, chronic inflammation have been proposed as causes cerebral aneurysm. Nevertheless, links between haemodynamic remain ill-defined, to clarify such links, we evaluated the effects prostaglandin E(2) (PGE(2) ), mediator inflammation, on formation aneurysms.Expression COX E synthase (PGES) PGE receptors were...
For the safe clinical application of embryonic stem cells (ESCs) for neurological diseases, it is critical to evaluate tumorigenicity and function human ESC (hESC)‐derived neural in primates. We have herein, first time, compared growth hESC‐derived with different stages differentiation implanted brains primate models Parkinson's disease. herein show that residual undifferentiated expressing markers present cell preparation can induce tumor formation monkey brain. In contrast, a matured by...
The spinal cord contains more than 20 distinct subclasses of neurons that form well-organized neural circuits capable sensing the environment and generating motor behavior. Although recent studies have described efficient in vitro generation neurons, induction as a whole tissue has not been achieved. In present study, we demonstrate three-dimensional (3D) dorsal cord-like tissues from human pluripotent stem cells. Our 3D (3-DiSC) condition recapitulates patterning developing enables four...
Semantic memory is a crucial higher cortical function that codes the meaning of objects and words, when impaired after neurological damage, patients are left with significant disability. Investigations semantic dementia have implicated anterior temporal lobe (ATL) region, in general, as for multimodal memory. The potentially role ventral ATL subregion has been emphasized by recent functional neuroimaging studies, but necessity this precise area not selectively tested. implantation subdural...
OBJECTIVE In this paper, the authors set out to identify angiographic features of moyamoya disease with posterior hemorrhage, which is a strong predictor rebleeding. METHODS This cross-sectional study used data Japan Adult Moyamoya Trial (clinical trial registration no.: C000000166 [ www.umin.ac.jp/ctr/index.htm ]). The panel designed ancillary measurement angiography at onset, classifying collateral vessels into 3 subtypes: lenticulostriate anastomosis, thalamic and choroidal anastomosis....
Background P.R4810K of RNF 213 (mysterin: rs112735431), which is an AAA + ATP ase, the susceptibility polymorphism for moyamoya disease ( MMD ) in East Asians. However, role R4810K etiology unknown. Methods and Results To clarify known angiogenic pathways, expression was analyzed endothelial cells EC s) treated with several antiangiogenic factors, including interferons IFN s). upregulated by ‐β through signal transducer activator transcription x promoter mediated activity ‐β. wild‐type WT...
Abstract The preservation of language function during brain surgery still poses a challenge. No intraoperative methods have been established to monitor the network reliably. We aimed establish monitoring by means cortico‐cortical evoked potentials (CCEPs). Subjects were six patients with tumors located close arcuate fasciculus (AF) in language‐dominant left hemisphere. Under general anesthesia, anterior perisylvian area (AL) was first defined CCEP connectivity patterns between ventrolateral...