A5028072590- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Autoimmune Neurological Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Pharmacological Effects and Toxicity Studies
- Peripheral Neuropathies and Disorders
- Neurobiology of Language and Bilingualism
- Advanced Neuroimaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Muscle activation and electromyography studies
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Motor Control and Adaptation
- Transcranial Magnetic Stimulation Studies
- Neonatal and fetal brain pathology
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Infectious Encephalopathies and Encephalitis
- Action Observation and Synchronization
- Genetic Neurodegenerative Diseases
Kyoto University
2016-2025
Keio University
2024-2025
Kobe University
2011-2025
Kobe University Hospital
2022-2024
The University of Tokyo
2022-2024
Osaka University
1991-2022
National Hospital Organization
2013-2022
Obayashi (Japan)
2022
Kobe Institute Of Computing
2022
National Center of Neurology and Psychiatry
2022
A better understanding of the mechanisms involved in human higher cortical functions requires a detailed knowledge neuronal connectivity between functional regions. Currently no good method for tracking vivo exists. We investigated inter-areal connections language system using new method, which we termed 'cortico-cortical evoked potentials' (CCEPs). Eight patients with epilepsy (age 13-42 years) underwent invasive monitoring subdural electrodes surgery. Six had dominance on side grid...
In order to understand the complex functional organization of motor system, it is essential know anatomical and connectivity among individual areas. Clinically, knowledge these cortico-cortical connections important rapid spread epileptic discharges through network underlying ictal manifestation. humans, however, neuronal in vivo has been limited. We recently reported a new method, 'cortico-cortical evoked potential (CCEP)', electrically track by stimulating part brain subdural electrodes...
Semantic memory is a crucial higher cortical function that codes the meaning of objects and words, when impaired after neurological damage, patients are left with significant disability. Investigations semantic dementia have implicated anterior temporal lobe (ATL) region, in general, as for multimodal memory. The potentially role ventral ATL subregion has been emphasized by recent functional neuroimaging studies, but necessity this precise area not selectively tested. implantation subdural...
Abstract The preservation of language function during brain surgery still poses a challenge. No intraoperative methods have been established to monitor the network reliably. We aimed establish monitoring by means cortico‐cortical evoked potentials (CCEPs). Subjects were six patients with tumors located close arcuate fasciculus (AF) in language‐dominant left hemisphere. Under general anesthesia, anterior perisylvian area (AL) was first defined CCEP connectivity patterns between ventrolateral...
Abstract Parieto‐frontal network is essential for sensorimotor integration in various complex behaviors, and its disruption associated with pathophysiology of apraxia visuo‐spatial disorders. Despite advances knowledge regarding specialized cortical areas transformations, little known about the underlying cortico‐cortical connectivity humans. We investigated inter‐areal connections lateral parieto‐frontal vivo by means evoked potentials (CCEPs). Six patients epilepsy one brain tumor were...
Electrocorticograms (ECoG) provide a unique opportunity to monitor neural activity directly at the cortical surface. Ten patients with subdural electrodes covering ventral and lateral anterior temporal regions (ATL) performed picture naming task. Temporal representational similarity analysis (RSA) was used, for first time, compare spatio-temporal patterns from ATL surface pre-defined theoretical models. The results indicate that in subregion of codes semantic representations 250 msec after...
This paper provides an overview of the design means-tested Guaranteed Minimum Income schemes, which constitute important component social protection systems in European countries.It discusses how key features differ across countries, including countries balance primary objective poverty alleviation against desire to both manage work disincentives inherent such programs and contain fiscal cost.The analysis finds a clear trade-off between concerns practice, with many combining low generosity...
In human, both primary and nonprimary motor areas are involved in the control of voluntary movements. However, dynamics functional coupling among different has not been fully clarified yet. Because it proposed that cortical might be achieved by synchronization oscillatory activity, we investigated electrocorticographic coherence between supplementary sensorimotor (SMA S1-M1) means event-related partial analysis 11 intractable epilepsy patients. We found premovement increase SMA proper S1-M1...
Summary: Purpose: A few reports have described focal electroencephalographic or clinical features both of juvenile myoclonic epilepsy (JME), but without video‐EEG documentation. We examined and EEG in patients with JME who underwent monitoring. Methods: Twenty‐six (nine males 17 females) had seizures recorded during monitoring were included. Age at seizure onset was 0 to 22 years (mean, 12.3 years), age 12 44 26.5 years). In one patient left parietooccipital epilepsy, primary generalized...
Summary: Purpose: This study was conducted to investigate the effect of low‐frequency electric cortical stimulation on epileptic focus in humans. Methods: We stimulated a patient with medically intractable mesial temporal lobe epilepsy (MTLE) by means subdural electrodes and evaluated change number interictal epileptiform discharges. used biphasic current 0.3‐ms duration presented at 0.9‐Hz frequency for 250 s, comparing stimulus intensity 7.5, 2, 0.5 mA. Results: Interictal discharges ictal...
Abstract Sleep‐induced changes in human brain connectivity/excitability and their physiologic basis remain unclear, especially the frontal lobe. We investigated sleep‐induced connectivity excitability 11 patients who underwent chronic implantation of subdural electrodes for epilepsy surgery. Single‐pulse electrical stimuli were directly injected to a part cortices, cortico‐cortical evoked potentials (CCEPs) CCEP‐related high‐gamma activities (HGA: 100–200 Hz) recorded from adjacent remote...
Abstract In order to preserve postoperative language function, we recently proposed a new intraoperative method monitor the integrity of dorsal pathway (arcuate fasciculus; AF) using cortico–cortical evoked potentials (CCEPs). Based on further investigations (20 patients, 21 CCEP investigations), including patients who were not suitable for awake surgery (five investigations) or those without preoperative neuroimaging data (eight four with untraceable tractography due brain edema), attempted...
How does the human brain encode semantic information about objects? This paper reconciles two seemingly contradictory views. The first proposes that local neural populations independently features; second, representations arise as a dynamic distributed code changes radically with stimulus processing. Combining simulations well-known network model of memory, multivariate pattern classification, and electrocorticography, we find both views are partially correct: animacy depicted is across...
Abstract Neurocognitive models of semantic memory have proposed that the ventral anterior temporal lobes (vATLs) encode a graded and multidimensional space—yet neuroimaging studies seeking brain regions structure rarely identify these areas. In simulations, we show this discrepancy may arise from crucial mismatch between theory analysis approach. Utilizing an recently formulated to investigate representations, representational similarity learning (RSL), decoded ECoG data collected vATL...
To determine whether patients with neocortical epilepsy show evidence for increased excitability measured by cortico-cortical evoked potentials (CCEPs) in ictal-onset regions.In undergoing intracranial recordings subdural electrodes surgery, we amplitudes, latencies, and stimulus thresholds of CCEPs near ictal onset zones (iCCEPs), compared adjacent neocortex not associated EEG (nCCEP). CCEP amplitude latency measurements were made each stimulation site, using graded intensities.Ten included...
Abstract In the dual-stream model of language processing, exact connectivity ventral stream to anterior temporal lobe remains elusive. To investigate between inferior frontal gyrus (IFG) and lateral part parietal lobes, we integrated spatiotemporal profiles cortico-cortical evoked potentials (CCEPs) recorded intraoperatively in 14 patients who had undergone surgical resection for a brain tumor or epileptic focus. Four-dimensional visualization combined CCEP data showed that pars opercularis...