The present retrospective study was undertaken to prove the reliability of aspect ratio (aneurysm depth aneurysm neck width) for predicting an aneurysmal rupture. is considered a better geometric index than size determining intra-aneurysmal blood flow.We measured ratios and sizes aneurysms, as determined by examining angiographic films magnified 1.4x, in 129 patients with ruptured aneurysms 72 78 unruptured aneurysms. After categorizing into four groups on basis their locations (aneurysms...

The present study was undertaken to explore the relationship between characteristic geometry of aneurysms prone rupture and blood flow patterns therein, using microsurgically produced that simulated human middle cerebral artery in scale shape.We measured vivo velocity profiles our 20-MHz, 80-channel, Doppler ultrasound velocimeter. We small (< or =5 mm, 5 cases) large (6-13 12 with round, dumbbell, multilobular shapes.The fundamental intra-aneurysmal were composed inflow, circulating flow,...

Abstract: We have isolated a human cDNA encoding protein, designated DNPI, that shows 82% amino acid identity and 92% similarity to the brain‐specific Na + ‐dependent inorganic phosphate (Na /P i ) cotransporter (BNPI), which is localized exclusively neuron‐rich regions. Expression of DNPI mRNA in Xenopus oocytes resulted significant increase P transport, indicating novel cotransporter. Northern blot analysis expressed predominantly brain, where highest levels are observed medulla,...

Context: Cabergoline fails to normalize hyperprolactinemia in a considerable proportion of prolactinomas, especially macroadenomas. Objective: We examined the effect individualized high-dose cabergoline treatment on prolactinomas. Patients: The study included 122 women and 28 men (93 microadenomas 57 macroadenomas). Forty-seven had undergone transsphenoidal surgery. According preceding medical treatment, participants were separated into untreated (group U; n = 60), intolerant I; 64),...

No prospective study of gamma knife thalamotomy for intractable tremor has previously been reported.To clarify the safety and optimally effective conditions performing unilateral (GK) tremors Parkinson disease (PD) essential (ET), a systematic postirradiation 24-month follow-up was conducted at 6 institutions. We present results this multicenter collaborative trial.In total, 72 patients (PD characterized by tremor, n = 59; ET, 13) were registered Japanese Following our selective procedure,...

Drug-resistant epilepsy associated with hypothalamic hamartomas (HHs) can be cured by microsurgical resection of the lesions. Morbidity and mortality rates for microsurgery in this area are significant. Gamma knife surgery (GKS) is less invasive seems to well adapted indication. To evaluate safety efficacy GKS treat uncommon pathological condition, we organized a multicenter retrospective study. Ten patients were treated seven different centers. The follow-up periods more than 12 months...

In human, both primary and nonprimary motor areas are involved in the control of voluntary movements. However, dynamics functional coupling among different has not been fully clarified yet. Because it proposed that cortical might be achieved by synchronization oscillatory activity, we investigated electrocorticographic coherence between supplementary sensorimotor (SMA S1-M1) means event-related partial analysis 11 intractable epilepsy patients. We found premovement increase SMA proper S1-M1...

To understand the molecular processes of continuous vasospasm cerebral arteries after subarachnoid hemorrhage, mRNA differential display and screening cDNA expression array were performed to identify genes that are differentially expressed in vasospastic canine two-hemorrhage models. The levels 18 found be upregulated, those two down-regulated. Of these, 12 represent known or homologues characterized previously, other eight not related any sequences databases. include five upregulated...

A SUBTEMPORAL AMYGDALOHIPPOCAMPECTOMY technique has been developed for mesial temporal lobe epilepsy. The conventional subtemporal approach modified to diminish retraction and the risk of damage lobe. In new technique, surgeons' position moved from above below changed anterolateral posterolateral, thereby avoiding voluminous steeply inclined anterior By this approach, it was unnecessary remove roof external auditory meatus estimated that both pressure extent were reduced. To date, surgeons...

In order to clarify further the characteristics of ictal direct current (DC) shifts in human epilepsy, we investigated them by subdural and scalp recording six three patients, respectively, both having mainly neocortical lobe epilepsy (five with frontal two parietal temporal epilepsy). By using electrodes made platinum, DC were observed 85% all recorded seizures (89 seizures) among they localized just one or at which conventional initial EEG change was also observed. They closely accompanied...

Endoscopes have been commonly used in transsphenoidal surgery to treat pituitary tumors, compensate for the narrow surgical field. Although many navigation systems introduced neurosurgical procedures, there few reports of endoscopic operations. This report presents our recently developed, endoscopic, augmented reality (AR) system.The technology is based on principles AR environment technology. The system consisted a rigid endoscope with light-emitting diodes, an optical tracking system, and...

ABSTRACT OBJECTIVE Drug-resistant epilepsy associated with hypothalamic hamartomas (HHs) can be cured by microsurgical resection of the lesions. Morbidity and mortality rates for microsurgery in this area are significant. Gamma knife surgery (GKS) is less invasive seems to well adapted indication. METHODS To evaluate safety efficacy GKS treat uncommon pathological condition, we organized a multicenter retrospective study. Ten patients were treated seven different centers. The follow-up...

The authors analyzed of the long-term complications that occur 2 or more years after gamma knife surgery (GKS) for intracranial arteriovenous malformations (AVMs).Patients with previously untreated AVMs were managed by GKS and followed at least treatment selected analysis (237 cases). Complete AVM obliteration was attained in 130 cases (54.9%), incomplete 107 (45.1%). Long-term observed 22 patients (9.3%). These included hemorrhage (eight cases), delayed cyst formation increase seizure...

Background and Purpose —The possible role of inflammatory reaction the cerebral artery in pathogenesis vasospasm has been noted recent studies. We quantitatively measured levels expression genes related to inflammation spastic a canine double-hemorrhage model. Methods —Twenty dogs were assigned 4 groups: group D0, control; D2, killed 2 days after cisternal injection blood; D7, given double injections blood 7 first injection; D14. Angiography was performed twice: on day before animals killed....

Clinical and radiological features that help predict the growth potential of meningioma would be beneficial. The purpose this study is to clarify characteristics related proliferating using MIB-1 staining index. We analyzed relationship indices 342 consecutive patients with surgically removed between 1995 2004 by logistic regression analysis. One hundred forty-nine were >or=60 in age; 89 male; 48 recurrent; 203 symptomatic; 157 at skull base; 124 over 20 cm(3); 24 multiple; 136 edema; 117...

Cabergoline is effective for hyperprolactinemic hypogonadism. However, the rate of cabergoline-induced pregnancy in women with prolactinoma remains unknown. Also unknown whether cabergoline can control tumor growth and thereby achieve successful patients macroprolactinomas.Eighty-five macroprolactinomas (n = 29) or microprolactinomas 56) received prospective, high-dose therapy infertility based on individual prolactin suppression and/or shrinkage. The included 31 bromocriptine-resistant, 32...

Summary Background. Radical resection of gliomas can increase patient' s survival. There is known concern, however, that aggressive tumour removal result in neurological morbidity. The objective the present study was to evaluate usefulness low magnetic field strength (0.3 Tesla) open intraoperative resonance imaging (iMRI) for complete glioma with emphasis on functional outcome. Methods. From 2000 2004, 96 patients intracranial underwent use iMRI Tokyo Women 's Medical University. were 50...

The objective of the present study was an evaluation incidence and risk factors for erroneous histopathological diagnosis low-grade glioma after stereotactic biopsy. Twenty-eight tumors diagnosed as biopsy surgically resected thereafter were analyzed. There 13 astrocytomas, 7 oligodendrogliomas, 8 mixed gliomas. All neoplasms had a lobar location. Seven contrast enhancement on MRI. number tissue samples obtained during one in 19 cases, two 4, three or more 5. Complete diagnostic agreement...

Ninety-two patients with pituitary adenomas have been treated during the last 5 years. Sixty-three of these had more than 6 months follow-up, and they form basis this report. Eighteen non-functioning (NFA), 36 functioning (FA). The mean marginal dose was 22.5 Gy (NFA 19.5 Gy, FA 23.9 Gy). Control tumor growth achieved in 92%. A significant decrease excessive hormone production seen 75.6%, endocrinopathy normalization rate 26.7%. Post-radiosurgical complications were 4.7%.

Object. The purpose of this study was the analysis a large series patients treated with gamma knife radiosurgery for pituitary adenoma in single institution. Methods. One hundred eight adenomas were over last 7 years. Seventy-four have been followed more than 6 months and form basis report. Conclusions. Twenty-three harbored nonfunctioning adenomas, 56 functioning adenomas. mean margin dose 22.5 Gy (nonfunctioning 19.5 Gy; 23.8 Gy). Control tumor growth achieved 91%. A significant decrease...