A5010549225- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Immune Cell Function and Interaction
- Brain Metastases and Treatment
- Photodynamic Therapy Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- T-cell and B-cell Immunology
- Dialysis and Renal Disease Management
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Renal Diseases and Glomerulopathies
- Cancer, Hypoxia, and Metabolism
- NF-κB Signaling Pathways
- Antenna Design and Analysis
- MRI in cancer diagnosis
- Vascular Malformations Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Blood Pressure and Hypertension Studies
- Anatomy and Medical Technology
Nihon University
2016-2025
National Institute of Dental and Craniofacial Research
2013-2025
Tokyo Women's Medical University
2015-2024
National Institutes of Health
2010-2024
Akita University
2016-2023
Tohoku University
2011-2023
Tokyo University of Science
1952-2023
National Center of Neurology and Psychiatry
2023
Fukuda Denshi (Japan)
2021
Nikon (United States)
2021
Abstract The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack clarity detrimental efforts identify therapeutic targets. Here we show that chondrocytes under inflammatory conditions undergo a metabolic shift regulated by NF-κB activation, leading reprogramming cell metabolism towards glycolysis lactate dehydrogenase A (LDHA). Inflammation can reciprocally modulate each other regulate cartilage degradation. LDHA binds NADH promotes...
Object The objective of the present study was to perform a prospective evaluation potential efficacy and safety intraoperative photodynamic therapy (PDT) using talaporfin sodium irradiation 664-nm semiconductor laser in patients with primary malignant parenchymal brain tumors. Methods In 27 suspected newly diagnosed or recurrent tumors, single intravenous injection (40 mg/m 2 ) administered 1 day before resection neoplasm. next after completion tumor removal, residual lesion and/or cavity...
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter...
<b>BACKGROUND AND PURPOSE:</b> Positron-emission tomography (PET) is a useful tool in oncology. The aim of this study was to assess the metabolic activity gliomas using <sup>11</sup>C-methionine (MET), [<sup>18</sup>F] fluorodeoxyglucose (FDG), and <sup>11</sup>C-choline (CHO) PET explore correlation between histopathologic features. <b>MATERIALS METHODS:</b> examinations were performed for 95 primary (37 grade II, 37 III, 21 IV). We measured tumor/normal brain uptake ratio (T/N ratio) on...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a major public health concern. The recent identification of the mTOR complex 1 (mTORC1) signaling pathway as highly prevalent molecular signature underlying HNSCC pathogenesis has provided foundation to search for novel therapeutic approaches prevent treat HNSCC. Here, we asked whether metformin, most widely used medication treatment type II diabetes, which acts in part by stimulating AMP-activated protein kinase (AMPK) thereby...
Background: We evaluated the erythropoietic effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, in type diabetes patients with anemia chronic kidney disease. Methods: Nine were enrolled and administered 100 mg canagliflozin once day for 12 weeks. The received fixed doses conventional antidiabetic drugs renin-angiotensin system inhibitors 8 weeks before enrollment; these continued during study. Endpoints changes erythropoiesis parameters, including erythrocyte reticulocyte...
Historically, red yeast rice (Red koji) has been a cornerstone in the culinary and medicinal traditions of East Asia, contributing to production alcoholic beverages, fermented foods, and, notably, tofuyo—a tofu delicacy originating from Okinawa, Japan, since eighteenth century (Supplementary Figure S1, S2). The discovery monacolin K, natural statin, within Monascus fungi catalyzed development lovastatin, heralding new era hyperlipidemia management worldwide.
Summary Background. Radical resection of gliomas can increase patient' s survival. There is known concern, however, that aggressive tumour removal result in neurological morbidity. The objective the present study was to evaluate usefulness low magnetic field strength (0.3 Tesla) open intraoperative resonance imaging (iMRI) for complete glioma with emphasis on functional outcome. Methods. From 2000 2004, 96 patients intracranial underwent use iMRI Tokyo Women 's Medical University. were 50...
The objective of the present study was an evaluation incidence and risk factors for erroneous histopathological diagnosis low-grade glioma after stereotactic biopsy. Twenty-eight tumors diagnosed as biopsy surgically resected thereafter were analyzed. There 13 astrocytomas, 7 oligodendrogliomas, 8 mixed gliomas. All neoplasms had a lobar location. Seven contrast enhancement on MRI. number tissue samples obtained during one in 19 cases, two 4, three or more 5. Complete diagnostic agreement...
OBJECT There is no standard therapeutic strategy for low-grade glioma (LGG). The authors hypothesized that adjuvant therapy might not be necessary LGG cases in which total radiological resection was achieved. Accordingly, they established a treatment based on the extent of (EOR) and MIB-1 index: patients with high EOR low index were observed without postoperative treatment, whereas those and/or received radiotherapy (RT) chemotherapy. In present retrospective study, reviewed clinical data...
The air dose outside of buildings due to primary and scattered radiation released by atomic bombs in Hiroshima Nagasaki was estimated as a function distance from the hypocenter. Neutron 60Co activity iron imbedded concrete gamma thermoluminescence bricks tiles. precision (coefficient variation) estimation less than 0.11 for gamma-rays 0,15 neutrons, results compared with York's values show only minor difference agree that neutrons Nagasaki, but large approximately 50 per cent 30–70 at...
The objective in the present study was to evaluate usefulness of cortico-cortical evoked potentials (CCEP) monitoring for intraoperative assessment speech function during resection brain tumors.Intraoperative CCEP applied 13 patients (mean age 34 ± 14 years) removal neoplasms located within or close language-related structures dominant cerebral hemisphere. For this purpose strip electrodes were positioned above frontal language area (FLA) and temporal (TLA), which identified with direct...
Antigen-specific regulatory T cells induced in vivo have therapeutic effects mice with established autoimmune diseases.
Glioma surgery represents a significant advance with respect to improving resection rates using new surgical techniques, including intraoperative functional mapping, monitoring, and imaging. Functional mapping under awake craniotomy can be used detect individual eloquent tissues of speech and/or motor functions in order prevent unexpected deficits promote extensive resection. In addition, monitoring the patient’s neurological findings during is also very useful for maximizing removal rate...
OBJECTIVE WHO Grade III gliomas are relatively rare and treated with multiple modalities such as surgery, chemotherapy, radiotherapy. The impact of the extent resection (EOR) on improving survival in patients this tumor type is unclear. Moreover, because heterogeneous radiological appearance gliomas, MRI sequence that best correlates volume unknown. In present retrospective study, authors evaluated prognostic significance EOR. METHODS Clinical data from 122 newly diagnosed who had undergone...
OBJECTIVE In this study on the effectiveness and safety of photodynamic therapy (PDT) using talaporfin sodium a semiconductor laser, long-term follow-up results 11 patients with glioblastoma enrolled in authors’ previous phase II clinical trial (March 2009–2012) 19 consecutive newly diagnosed prospectively postmarket surveillance 2014–December 2016) were analyzed compared those 164 treated without PDT during same period. METHODS The main outcome measures median overall survival (OS)...
The relationship of (11)C-methionine (MET) uptake and tumor activity in low-grade gliomas (those meeting the criteria for World Health Organization [WHO] grade II gliomas) remains uncertain. aim this study was to compare MET analyze whether positron-emission tomography (PET) can estimate viability provide evidence malignant transformation.We studied glioma metabolic 49 consecutive patients with newly diagnosed by using PET before surgical resection. On PET, we measured tumor/normal brain...