A5055033211- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Osteoarthritis Treatment and Mechanisms
- Wound Healing and Treatments
- Virus-based gene therapy research
- Angiogenesis and VEGF in Cancer
- Nanoparticle-Based Drug Delivery
- Silk-based biomaterials and applications
- Dental Implant Techniques and Outcomes
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Proteoglycans and glycosaminoglycans research
- Advanced biosensing and bioanalysis techniques
- Nerve injury and regeneration
- Tendon Structure and Treatment
- Advanced Drug Delivery Systems
- Liver physiology and pathology
- Hydrogels: synthesis, properties, applications
- Reconstructive Surgery and Microvascular Techniques
- Tracheal and airway disorders
Kyoto University
2016-2025
National University of Malaysia
2022
Frontier Medical College
2000-2019
Wake Forest University
2019
Forest Institute
2019
Charlottesville Medical Research
2019
John Wiley & Sons (United States)
2019
Nationwide Children's Hospital
2019
The Ohio State University
2019
Kyoto Prefectural University of Medicine
2016-2018
An injectable, biodegradable hydrogel composite of oligo(poly(ethylene glycol) fumarate) (OPF) and gelatin microparticles (MPs) has been investigated as a cell growth factor carrier for cartilage tissue engineering applications. In this study, composites with different swelling ratios were prepared by cross-linking OPF macromers poly(ethylene (PEG) repeating units varying molecular weights from 1000 approximately 35000. Rabbit marrow mesenchymal stem cells (MSCs) MPs loaded transforming...
Four dimensional (4D) printing is an emerging technology with great capacity for fabricating complex, stimuli-responsive 3D structures, providing potential tissue and organ engineering applications. Although the 4D concept was first highlighted in 2013, extensive research has rapidly developed, along more-in-depth understanding assertions regarding definition of 4D. In this review, we begin by establishing criteria printing, followed summary state-of-the-art technological advances field....
The objective of the study was to test hypothesis that platelet-rich plasma (PRP) enhances meniscal tissue regeneration in vitro and vivo. In study, monolayer cell cultures were prepared, 3-(4,5-dimethylthiazol-2yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt assay 5-bromo-2′-deoxyuridine performed assess proliferative behavior presence PRP. Alcian blue extracellular matrix (ECM) synthesis. To detect fibrocartilage-related messenger ribonucleic acid (mRNA)...
Spinal cord injury (SCI) is one of the most debilitating injuries, and transplantation stem cells in a scaffold promising strategy for treatment. However, cell treatment SCI has been severely impaired by increased generation reactive oxygen species lesion microenvironment, which can lead to high level death dysfunction. Herein, MnO2 nanoparticle (NP)-dotted hydrogel prepared through dispersion NPs PPFLMLLKGSTR peptide modified hyaluronic acid hydrogel. The peptide-modified enables adhesive...
Inflammation is a temporary response of the immune system that can be treated using common anti-inflammatory drugs. However, prolonged use these drugs increases risk adverse side effects. Accordingly, there an increasing need for alternative treatments inflammation with fewer Exosomes are extracellular vesicles secreted by most eukaryotic cells and have been studied as candidate cell-free therapy inflammatory diseases due to their immunomodulatory properties. In recent years, focus exosome...
In vivo release of basic fibroblast growth factor (bFGF) from a biodegradable gelatin hydrogel carrier was compared with the in degradation hydrogel. When hydrogels incorporating 125I-labeled bFGF were implanted into back subcutis mice, radioactivity remaining decreased time and retention period prolonged decrease water content hydrogels. The lower hydrogels, faster both weight time. decrement profile correlated that radioactivity, irrespective content. Subcutaneous implantation...
The dose effect of dual delivery vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) on regeneration was investigated in a rat cranial critical-size defect (CSD). It hypothesized that decreasing amounts BMP-2 would result dose-dependent decrease formation, this reduction formation could be reversed by adding increasing VEGF. In vitro release kinetics VEGF or were examined over 28 days. Next, scaffolds implanted within CSD containing different combinations both...
A variety of biodegradable microspheres were prepared from L-lactic acid, DL-lactic or glycolic acid homopolymers and copolymers different molecular weights monomer compositions. Phagocytosis the by mouse peritoneal macrophages was studied in cell culture system using scanning electron microscopy as well light microscopy. The diameter less than 2 microns, regardless starting polymers. No dependence chemical nature polymers observed on extent phagocytosis macrophages. Precoating with...