A5014651312- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Facial Trauma and Fracture Management
- Dental Implant Techniques and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Lymphatic System and Diseases
- Bone fractures and treatments
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- Orthopedic Infections and Treatments
- Advanced Drug Delivery Systems
- Osteoarthritis Treatment and Mechanisms
- Mechanical Circulatory Support Devices
- Pluripotent Stem Cells Research
- Cardiac Structural Anomalies and Repair
- Planarian Biology and Electrostimulation
- Nerve injury and regeneration
- Angiogenesis and VEGF in Cancer
- Physical Activity and Health
- Body Contouring and Surgery
Apple (United States)
2021-2024
Rice University
2007-2015
Baylor College of Medicine
2010-2014
Otto-von-Guericke University Magdeburg
1999
Abstract Background Bone marrow-derived mesenchymal stem cells (BMSCs) are a widely researched adult cell population capable of differentiation into various lineages. Because many promising applications tissue engineering require expansion following harvest and involve the treatment diseases conditions found in an aging population, effect donor age ex vivo handling must be understood order to develop clinical techniques therapeutics based on these cells. Furthermore, there currently exists...
Engineering complex tissues requires a precisely formulated combination of cells, spatiotemporally released bioactive factors, and specialized scaffold support system. Injectable materials, particularly those delivered in aqueous solution, are considered ideal delivery vehicles for cells factors can also be through minimally invasive methods fill 3D shapes. In this review, we examine injectable materials that form scaffolds or networks capable both replacing tissue function early after...
A smartwatch-based sensing system measures tremor and dyskinesia, enabling remote monitoring aiding medication titration in Parkinson’s disease.
The dose effect of dual delivery vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) on regeneration was investigated in a rat cranial critical-size defect (CSD). It hypothesized that decreasing amounts BMP-2 would result dose-dependent decrease formation, this reduction formation could be reversed by adding increasing VEGF. In vitro release kinetics VEGF or were examined over 28 days. Next, scaffolds implanted within CSD containing different combinations both...
The need for techniques to facilitate the regeneration of failing or destroyed tissues remains great with aging worldwide population and continued incidence trauma diseases such as cancer. A 16-year history in biomaterial scaffold development tissue engineering is examined, beginning synthesis novel materials fabrication 3D porous scaffolds. Exploring cell-scaffold interactions subsequently cellular delivery using carriers, we have developed a variety bone cartilage engineering. In addition...
In this study, we synthesized and characterized a series of macromers based on poly( N-isopropylacrylamide) that undergo thermally induced physical gelation and, following chemical modification, can be chemically cross-linked. Macromers with number average molecular weights typically ranging from 2000-3500 Da were via free radical polymerization from, in addition to N-isopropylacrylamide, pentaerythritol diacrylate monostearate, bifunctional monomer containing long hydrophobic chain,...
Traumatic facial soft tissue injuries are commonly encountered in the emergency department by plastic surgeons and other providers. Although rarely life-threatening, treatment of these can be complex may have significant impact on patient's function aesthetics. This article provides a review relevant literature related to this topic describes authors' approach evaluation management patient with injuries.
For bone tissue engineering, the benefits of incorporating mesenchymal stem cells (MSCs) into porous scaffolds are well established. There is, however, little consensus on effects or need for MSC handling ex vivo. Culture and expansion MSCs adds length cost, likely increases risk associated with treatment. We evaluated effect using uncultured marrow mononuclear (bmMNCs) encapsulated within fibrin glue hydrogels seeded to regenerate over 12 weeks in an 8-mm-diameter, critical-sized rat...
This study investigated the delivery of plasmid DNA (pDNA) encoding bone morphogenetic protein-2 in form polyplexes with a biodegradable branched triacrylate/amine polycationic polymer (TAPP) that were complexed gelatin microparticles (GMPs) loaded within porous tissue engineering scaffold. More specifically, interplay between TAPP degradation, pDNA release, and formation critical-size rat cranial defect model. The release kinetics vitro not affected by crosslinking density GMPs but...
Background: The use of left ventricular assist devices has become common for the treatment end-stage heart failure, both as a bridge to transplantation and destination therapy. nature these comorbid conditions patients in whom are implanted lead high rates device infection that related directly mortality. Methods: Over 2 years, senior author (S.A.I.) treated 26 with infections, ranging from superficial driveline infections deeper pocket infections. An algorithm involving repeated débridement...
Current treatment of traumatic craniofacial injuries often involves early free tissue transfer, even if the recipient site is contaminated or lacks soft coverage. There are no current engineering strategies to definitively regenerate tissues in such an environment at time point. For a approach be employed injuries, two-stage could potentially used. The present study describes methods for fabrication, characterization, and processing porous polymethylmethacrylate (PMMA) space maintainers...
Stimulus responsive materials hold great promise in biological applications as they can react to changes physiological stimuli produce a desired effect. macromers designed respond temperature at or around 37 °C and the presence of divalent cations were synthesized from N-isopropylacrylamide, pentaerythritol diacrylate monostearate, 2-hydroxyethyl acrylate, vinylphosphonic acid by free radical polymerization. Monomers incorporated into ratios approximating molar feed ratios, underwent...
The reconstruction of large craniofacial defects remains a significant clinical challenge. complex geometry facial bone and the lack suitable donor tissue often hinders successful repair. One strategy to address both these difficulties is development an in vivo bioreactor, where flap can be orthotopically grown within same patient requiring reconstruction. Our group has previously designed such approach using chambers filled with morcellized autograft as scaffold autologously generate...