Toshio Machida
A5051059907- Intracranial Aneurysms: Treatment and Complications
- Atherosclerosis and Cardiovascular Diseases
- Moyamoya disease diagnosis and treatment
- Cell Adhesion Molecules Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Complications and Syndromes
- Acute Ischemic Stroke Management
- Monoclonal and Polyclonal Antibodies Research
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Diabetes and associated disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Protease and Inhibitor Mechanisms
- Spinal Fractures and Fixation Techniques
- Chemokine receptors and signaling
- Cancer-related Molecular Pathways
- Stroke Rehabilitation and Recovery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Galectins and Cancer Biology
- Neurosurgical Procedures and Complications
- Cervical and Thoracic Myelopathy
- Systemic Lupus Erythematosus Research
- Atrial Fibrillation Management and Outcomes
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
Chiba University
2004-2024
Chiba Cerebral and Cardiovascular Center
2012-2024
Teikyo University Chiba Medical Center
2018-2024
Chibaken Saiseikai Narashino Hospital
2017
Juntendo University Nerima Hospital
2012
Neurological Surgery
2005
Yazaki (Japan)
1994
Suzuki (Japan)
1994
Saku Central Hospital
1987
Background and Purpose— About one half of those who develop adult-onset moyamoya disease experience intracranial hemorrhage. Despite the extremely high frequency rebleeding attacks poor prognosis, measures to prevent have not been established. The purpose this study is determine whether extracranial–intracranial bypass can reduce incidence improve patient prognosis. Methods— This was a multicentered, prospective, randomized, controlled trial conducted by 22 institutes in Japan. Adult...
Background and Purpose— The primary results of the Japan Adult Moyamoya Trial revealed statistically marginal superiority bypass surgery over medical treatment alone in preventing rebleeding moyamoya disease. purpose this analysis is to test prespecified subgroup hypothesis that natural course surgical effects vary depending on hemorrhagic site at onset. Methods— site, classified as either anterior or posterior, was only stratifying variable for randomization. Statistical analyses were...
Long-term outcomes are unknown in patients with asymptomatic moyamoya disease. In this report, we aimed to clarify their 5-year risk of stroke and its predictors.We conducting a multicenter, prospective cohort study (Asymptomatic Moyamoya Registry) Japan. Participants were eligible if they 20 70 years, had bilateral or unilateral disease, experienced no episodes suggestive TIA stroke; functionally independent (modified Rankin Scale score 0-1). Demographic radiological information was...
Abstract Cathepsin D is an aspartyl protease involved in protein catabolism and tissue remodeling which can be secreted from cancer cells. To identify a potential serum marker for gliomas, we investigated the gene expression levels of cathepsin 87 samples measured concentrations sera glioma patients. The consisted 43 glioblastomas, 13 anaplastic astrocytomas, 22 9 normal brain tissues. results real-time quantitative reverse transcription-PCR analysis showed that transcript became...
Transient ischemic attack (TIA) is a predictor for cerebral infarction (CI), and early diagnosis of TIA extremely important the prevention CI. We set out to identify novel antibody biomarkers CI, detected matrix metalloproteinase 1 (MMP1), chromobox homolog (CBX1), 5 (CBX5) as candidate antigens using serological identification by recombinant cDNA expression cloning (SEREX) Western blotting confirm presence serum antibodies against antigens. Amplified luminescent proximity homogeneous...
Because circulating antibodies against a variety of antigens have been detected in patients with coronary heart disease, carotid atherosclerosis and those who suffered stroke, it is suspected that immune response may be one the mechanisms atherogenesis The objective this study to identify novel ischemic stroke by screening expressed recombinant proteins using human cDNA library (SEREX).To candidate antigens, was screened SEREX plasma from ten stroke. Subsequently, via ELISA synthetic...
The rupture of an intracranial aneurysm (IA) results in subarachnoid hemorrhage, a catastrophic neurological condition with high morbidity and mortality. Following-up on our previous genome-wide linkage study Japanese population, we extensively analyzed 4.6 Mb region around D7S2472 7q11 by genotyping 168 single nucleotide polymorphisms (SNPs). SNP association window scan haplotype-based studies revealed susceptibility locus for IA LD block covering the 3′-untranslated (3′-UTR) ELN entire...
Background Chronic subdural hematoma (CSDH) is known to have a substantial recurrence rate. Artificial cerebrospinal fluid (ACF) an effective irrigation solution in general open craniotomy and endoneurosurgery, but no evidence of its use burr-hole surgery exists. Objective To identify the potential ACF prevent CSDH recurrence. More specifically, investigate perioperative intraoperative prognostic factors, controllable ones. Methods examine various 120 consecutive patients with unilateral...
Serum antibody markers have been increasingly identified not only for cancer and autoimmune diseases but also atherosclerosis-related such as acute ischemic stroke (AIS), myocardial infarction (AMI), diabetes mellitus (DM), chronic kidney disease (CKD). Biomarkers transient attack (TIA) non-ST segment elevation coronary syndrome (NSTEACS) are potentially useful detection of early phase atherosclerotic changes against AIS AMI, respectively.
Abstract Some cancers are related to atherosclerotic diseases; therefore, these two types of disease may share some antibody biomarkers in common. To investigate this, a first screening sera was performed from patients with esophageal squamous cell carcinoma (ESCC) or acute ischemic stroke (AIS) for serological identification antigens using recombinant cDNA expression cloning (SEREX). The amplified luminescent proximity homogeneous assay‐linked immunosorbent assay (AlphaLISA) method, which...
Disease specific autoantibodies have been detected in the sera of patients with atherosclerosis-related diseases, such as cerebral infarction, cardiovascular disease. In present study, we aimed to identify novel responsible for transient ischemic attack (TIA), a prodromal condition infarction.To candidate antigens, screened human aortic endothelial cell cDNA library using from 20 TIA. Serum antibody levels were measured amplified luminescent proximity homogeneous assay-linked immunosorbent...
The aim of the present study was to identify novel antibody markers for early diagnosis atherosclerosis in order improve prognosis patients at risk acute ischemic stroke (AIS) and myocardial infarction (AMI). A first screening involved serological identification antigens by recombinant cDNA expression cloning identified additional sex combs‑like 2 (ASXL2) as a target antigen recognized serum IgG antibodies sera with atherosclerosis. Antigens, including glutathione S‑transferase‑fused ASXL2...
Abstract Background Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS Early diagnosis atherosclerosis, which the major AIS, allows therapeutic intervention before onset, leading to prevention AIS. Methods Serological identification by cDNA expression libraries protein array method were used for screening antigens recognized serum IgG antibodies in patients with atherosclerosis. Recombinant proteins or synthetic peptides derived from candidate as compare levels...
Atherosclerosis has been considered as the main cause of morbidity, mortality, and disability worldwide. The first screening for antigen markers was conducted using serological identification antigens by recombinant cDNA expression cloning, which identified adaptor-related protein complex 3 subunit delta 1 (AP3D1) an recognized serum IgG antibodies patients with atherosclerosis. Serum antibody levels were examined amplified luminescent proximity homogeneous assay-linked immunosorbent assay...
Abstract The presence of disease-specific antigens and autoantibodies in the sera patients with atherosclerosis-related diseases has been widely reported is considered to result from inflammation arterial wall involvement immune factors. aim this study was identify a novel antibody ischemic stroke by serological identification using recombinant cDNA expression cloning who had transient attack (TIA). We identified serpin peptidase inhibitor, clade E member 1 (SERPINE1), as candidate antigen....
Encephalo-myo-synangiosis (EMS) is an effective revascularization procedure for the treatment of moyamoya disease (MMD). However, temporalis muscle used EMS sometimes swells and causes ischemic complications by compressing underlying brain. This study aimed to elucidate effect sagittal splitting (SS) prevention its impact on postoperative development collateral vessels.
Here we report a case of moyamoya disease in which cortical veins reddened after superficial temporal artery (STA) to middle cerebral (MCA) anastomosis, following postoperative hyperperfusion. A 37-year-old man with suffered infarction his right hemisphere. Single photon emission computed tomography (SPECT) showed impaired blood flow (CBF) both hemispheres. The patient underwent STA-MCA anastomosis the During operation, soon declamping STA, near site changed its color from blue red. This...
Abstract Background: The discovery and development of novel biomarkers that could facilitate early diagnosis thus prevent the progression atherosclerosis-related diabetes mellitus (DM), cerebral infarction (CI), cardiovascular disease (CVD) has garnered much research interest. Notably, recent reports have described a number highly sensitive antibody markers. In this study, we aimed to identify additional markers would screening. Methods: amplified luminescent proximity homogeneous assay...
Atherosclerosis is associated with vascular diseases, diabetes, and cancers. The Jumonji C-domain-containing 6 (JMJD6) gene plays an important role in diverse biological processes. In addition, autoantibodies are reportedly useful the early diagnosis treatment of many diseases. Here, JMJD6 was identified by serological identification antigens recombinant cDNA expression cloning as antigen recognized serum IgG from patients unstable angina pectoris. Then, we performed amplified luminescent...
Numerous antibody biomarkers have been reported for cancer and atherosclerosis-related diseases. The major complications of atherosclerosis diabetes mellitus (DM) are acute ischemic stroke (AIS), cardiovascular disease (CVD) chronic kidney (CKD). Cancer development is accompanied by arterial disorders, such as angiogenesis atherosclerosis, DM a risk factor the certain types cancer. Atherosclerosis-related diseases cancers therefore interrelated could be detected using common biomarker. In...
We previously identified growth arrest and DNA-damage-inducible gene 34 (GADD34) as a marker of ischemic stroke. In the present study, serum levels anti-GADD34 antibodies were found to be significantly higher in patients with acute stroke or chronic kidney disease compared healthy donors. then examined biological function GADD34 by transfection into U2OS human osteosarcoma U87 glioblastoma cells. Knockdown siRNA resulted enhanced cell proliferation, which was reversed co-knockdown MDM2....