Hiroyuki Shimada

ORCID: 0000-0001-8298-3757
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About
Contact & Profiles
Research Areas
  • Intraocular Surgery and Lenses
  • Retinal and Macular Surgery
  • Retinal Diseases and Treatments
  • Ocular Infections and Treatments
  • Glaucoma and retinal disorders
  • Retinal and Optic Conditions
  • Vascular Malformations Diagnosis and Treatment
  • Retinal Imaging and Analysis
  • Ocular Diseases and Behçet’s Syndrome
  • Creativity in Education and Neuroscience
  • Ophthalmology and Visual Impairment Studies
  • Transcranial Magnetic Stimulation Studies
  • Medical Imaging Techniques and Applications
  • Neural and Behavioral Psychology Studies
  • Gaze Tracking and Assistive Technology
  • Corneal surgery and disorders
  • Alzheimer's disease research and treatments
  • Ocular Oncology and Treatments
  • Cardiac Imaging and Diagnostics
  • Academic and Historical Perspectives in Psychology
  • Ocular Surface and Contact Lens
  • Reading and Literacy Development
  • Cerebrospinal fluid and hydrocephalus
  • EEG and Brain-Computer Interfaces
  • Intracranial Aneurysms: Treatment and Complications

Nihon University
2015-2024

Hokuriku University
2023

Surugadai Nihon University Hospital
2009-2022

Kobe University
2010-2020

California Maritime Academy
2012-2018

Osaka City University
1998-2017

Tokyo Metropolitan Geriatric Hospital
1976-1991

Inoue Hospital
1990

Tokyo Metropolitan Institute of Gerontology
1981

To elucidate the pathogenic mechanism of polypoidal choroidal vasculopathy (PCV) based on histopathologic findings.Specimens obtained by surgical excision PCV from five eyes patients (mean age, 75.6 +/- 3.1 years) were studied histopathologically. Immunohistochemical studies also performed to identify CD34, vascular endothelial growth factor (VEGF), CD68, alpha-smooth muscle actin (alpha-SMA) and hypoxia-inducible (HIF)-1alpha.Hyalinization vessels massive exudation fibrin blood plasma...

10.1167/iovs.08-2134 article EN Investigative Ophthalmology & Visual Science 2008-10-29

This study compared the postoperative outcomes of 27-gauge (G) and 25-G vitrectomy performed for treatment idiopathic epiretinal membrane (ERM). The design was single center, retrospective, interventional case series. Two hundred consecutive eyes that underwent primary ERM (27-G in 100 eyes) were studied 6 months. In all eyes, scleral tunnels made using angle incisions, air or gas exchange performed. There no significant differences age, spherical diopter power, as well preoperative Early...

10.1186/s12886-017-0585-1 article EN cc-by BMC Ophthalmology 2017-10-10

To determine the size of foveal avascular zone (FAZ) by optical coherence tomography angiography before and after idiopathic epiretinal membrane surgery.Thirteen consecutive patients (13 eyes) with unilateral were studied retrospectively. Optical was used to measure FAZ area within 3 mm × scans superficial (superficial FAZ) deep plexus layers (deep 6 months vitrectomy. The unaffected fellow eyes as controls.The mean areas at vitrectomy (0.080 ± 0.038 0.113 0.045 mm, respectively)...

10.1097/iae.0000000000001972 article EN Retina 2017-12-12

10.1007/s00417-006-0367-6 article EN Graefe s Archive for Clinical and Experimental Ophthalmology 2006-05-31

Vascular endothelial growth factor (VEGF) concentrations in various regions of the vitreous were examined patients with diabetic macular edema (DME) to explore possibility a concentration gradient vitreous.Vitreous samples collected during vitrectomy from 71 eyes DME and without posterior detachment who had not undergone panretinal photocoagulation. Vitreous premacular mid-vitreous (group A, 35 eyes), peripheral cortical B, 36 eyes). Mean foveal thickness was measured by optical coherence...

10.1167/iovs.08-2870 article EN Investigative Ophthalmology & Visual Science 2009-05-26

In Brief Purpose: To investigate the bactericidal effect of 0.025% povidone–iodine in Balanced Salt Solution PLUS (0.025% PI–BSS PLUS) and its use vitrectomy for postoperative endophthalmitis. Methods: First, an experimental laboratory model using Staphylococcus aureus was used to evaluate PLUS. Next, a case series 4 eyes with endophthalmitis, as irrigation solution conducted, followed by intravitreal intravenous antibiotics. Results: vitro study, PI at concentrations 0.01% above BSS...

10.1097/iae.0000000000000634 article EN Retina 2015-05-06

To verify that ocular surface irrigation with 0.025% povidone-iodine (PI) or 0.0025% polyvinyl alcohol-iodine (PAI) during cataract surgery minimizes bacterial contamination of the anterior chamber.The study was a prospective, interventional case series. First, bactericidal effect PI PAI against Staphylococcus aureus evaluated in vitro. Next, 400 eyes undergoing surgery, irrigated every 20 seconds balanced salt solution (BSS; 200 eyes) BSS containing (100 eyes). At completion chamber fluid...

10.1111/aos.13390 article EN Acta Ophthalmologica 2017-03-08

In Brief Purpose: The purpose of this study was to examine the effect lower than usual doses intravitreal bevacizumab (Avastin) on vitreous vascular endothelial growth factor (VEGF) concentration and intraoperative bleeding when used as preoperative adjunct therapy in patients undergoing vitrectomy for proliferative diabetic retinopathy. Methods: Fifty-two eyes (52 patients) with indications were studied; 12 received bevacizumab, 40 did not. group given a single injection (0.16–1.25 mg) 3...

10.1097/iae.0b013e3181c70168 article EN Retina 2010-05-01

Subretinal fibrosis has been recognized as a feature of an advanced stage exudative age-related macular degeneration (AMD) that leads to irreversible loss vision. This study was aimed at elucidating roles interlukin-6 (IL-6) in the development subretinal fibrosis. Immunohistochemistry (IHC) performed with anti-human IL-6 antibody surgically excised choroidal neovascular tissues from patients AMD. The area measured mouse model injection control small interfering RNA(siRNA) or siRNA, isotype...

10.1080/09114300.2018.1451609 article EN cc-by Immunological Medicine 2018-01-02

To investigate the safety and effectiveness of intravitreal injection (IVI) 1.25% povidone iodine (PI) followed by vitrectomy using 0.025% PI irrigation for treating endophthalmitis.Prospective case series study. Nine eyes 8 patients with postoperative or endogenous endophthalmitis treated at Nihon University Hospital between April 2015 October 2017 were studied. First, IVI 0.1 mL/1.25%PI was conducted, anterior chamber 0.025%PI solution. Corneal epithelial damage, inflammation, vitreous...

10.1167/tvst.8.1.21 article EN cc-by-nc-nd Translational Vision Science & Technology 2019-02-13
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